2003
DOI: 10.1016/s0302-2838(03)00367-1
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Alpha-Blocker Therapy Can Be Withdrawn in the Majority of Men Following Initial Combination Therapy with the Dual 5α-Reductase Inhibitor Dutasteride

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Cited by 174 publications
(146 citation statements)
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“…Treatment with either drug significantly reduced BPH symptoms compared with placebo, but the combination therapy performed signifi-cantly better in alleviation of LUTS compared with monotherapy. The SMART-1 study showed that ␣-adrenergic receptor blockers used initially could be discontinued after 6 months without any loss of improvement from the combination therapy (21). However, treatment-resistant disease is still a considerable problem, and many men still fail medical therapy and go on to require invasive surgical intervention for symptomatic relief.…”
Section: Benign Prostatic Hyperplasia (Bph)mentioning
confidence: 99%
“…Treatment with either drug significantly reduced BPH symptoms compared with placebo, but the combination therapy performed signifi-cantly better in alleviation of LUTS compared with monotherapy. The SMART-1 study showed that ␣-adrenergic receptor blockers used initially could be discontinued after 6 months without any loss of improvement from the combination therapy (21). However, treatment-resistant disease is still a considerable problem, and many men still fail medical therapy and go on to require invasive surgical intervention for symptomatic relief.…”
Section: Benign Prostatic Hyperplasia (Bph)mentioning
confidence: 99%
“…Se puede concluir que 3 estudios 5-7 plantean objetivos clásicos basados en variables ampliamente aceptadas, mientras que los otros dos nacen de unos objetivos originales y por ello más novedosos pero basados en unas variables definidas por primera vez en dichos estudios [8][9] .…”
Section: Análisis De La Hipótesis Y Las Variablesunclassified
“…En primer lugar, se considera que un ensayo clínico de una patología como la HBP, que presenta una progresión lenta con altibajos en su sintomatología, ha de tener una duración mínima de un año y en dos de los estudios ésta es sólo de 6 meses 6,8 . Además, en uno de ellos, el estudio ALFIN 6 , no existe grupo control con placebo.…”
Section: Análisis De La Validez Internaunclassified
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“…According to this illustrative cost analysis the secondary-care costs associated with managing AUR and BPH-related surgery, common complications of BPH, stands at £111 568 793. This is almost 60% more than the amount spent on drugs to treat BPH (£69 228 637) and more than 3.5 times the expenditure on the 5ARI class of drugs (£29 170 450), which have been shown in several studies to not only improve LUTS but also to reduce the risks of both AUR and BPHrelated surgery by about half [3][4][5][6].The time and cost burden associated with primary-care consultations should also be considered when evaluating the effect of treating BPH within the NHS. In this cost analysis it is estimated that 1 648 830 GP consultations are for BPH at a total cost to the NHS of £44 518 410 per year.…”
mentioning
confidence: 99%