2020
DOI: 10.3389/fphar.2019.01684
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Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis

Abstract: Acarose is an anti-diabetic drug and exhibits anti-arthritic effects. We hypothesized that acarbose influences the gut microbiota to affect the course of arthritis and tested this hypothesis in a collagen-induced arthritis (CIA) murine model. Acarbose in drinking water was administered via gastric gavage started prior to or at the time of CIA induction. Gut microbiota were evaluated with 16S rRNA gene sequencing from fecal pellets collected prior to arthritis induction, during onset of arthritis, and after tre… Show more

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Cited by 36 publications
(27 citation statements)
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“…B. infantis intervention promoted the numbers of Rumencoccus and Clostridium and inhibited the numbers of Akkermansia, Escherichia and Coprococcus. These results are basically consistent with the report that the frequency of Lactobacillus, Anaeroplasma, Adlercreutzia, RF39 and Clostridium was significantly deceased in collagen-induced arthritis, which exhibited Th17/Treg imbalance [27]. Administration of L. salivarius and L. plantarum reduced the Th17 cell fraction and increased the Treg fraction [28].…”
Section: Discussionsupporting
confidence: 92%
“…B. infantis intervention promoted the numbers of Rumencoccus and Clostridium and inhibited the numbers of Akkermansia, Escherichia and Coprococcus. These results are basically consistent with the report that the frequency of Lactobacillus, Anaeroplasma, Adlercreutzia, RF39 and Clostridium was significantly deceased in collagen-induced arthritis, which exhibited Th17/Treg imbalance [27]. Administration of L. salivarius and L. plantarum reduced the Th17 cell fraction and increased the Treg fraction [28].…”
Section: Discussionsupporting
confidence: 92%
“…Fecal transplantation containing gut Rikenellaceae bacteria can alleviate acute liver injury in mice through regulating Treg/Th17 balance( Liu et al, 2021 ), while it cannot alleviate eosinophilic asthma. Corynebacterium may regulate Th17/Treg cells in the intestinal mucosal immunity ( Zhang et al, 2019 ); However, there are still no studies in allergic asthma. So far, we have not find relevant research about genus Desulfovibrio , genus Muribaculum or genus Prevotella 9 are related with Th17 cells percentage in eosinophilic asthma disease, they were the gut microbiota biomarker after TMDCT treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Dietary interventions have long been considered feasible and economical auxiliary options to improve symptoms in autoimmune diseases such as RA. There are some encouraging results obtained from clinical and laboratory studies, for example, using a-glucosidase inhibitors or high fibre-rich diets for RA therapy (121,122). All of the mechanistic investigations point to the involvement of gut microbiota in the above treatments.…”
Section: Treatment Strategy Based On Diet-induced Microbiota Adjustmentmentioning
confidence: 99%