Alpha-interferon in Kikuchi’s disease

Analysis of herpesvirus genomes in Kikuchi's disease

“…Because of these clinical manifestations, protozoa, microorganisms or viruses were thought to be causative agents. Elevated serum concentrations of 2'-5' oligoadenylate synthetase in the early stage of the disease (Kikuchi et al 1990;Sumiyoshi et al 1991a); the fragmentary appearance of tubuloreticular structures in the lymphocytes, histiocytes, and vascular endothelial cells (Eimoto et al 1983;Imamura et al 1982); and the recognition of numerous interferon-d possessing cells in the affected area (Sumiyoshi et al 1991b) intensified the suspicion of viral infection. Some authors postulated the causative agents for Kikuchi's disease to be EBV (Takada et al 1980) andHHV-6 (Eizuru et al 1989) but no identification of a causative virus has been achieved.…”

Evaluation of 44 Kikuchi-Fujimoto Disease Cases Reported from Turkey Between 2000-2010 with Pooled Analysis Method

“…45 Hastalığın klinik tablosu ve lenf bezlerindeki hücrelerin elektron mikroskobik incelenmesinde intraselüler tübüloretiküler yapı-ların görülmesi de viral enfeksiyonlar ve SLE gibi otoimmün hastalıkları akla getirmektedir. 16 Fakat bu etkenlere yönelik özgül testler ve kültürlerin genellikle negatif olması, polimeraz zincir reaksiyonu (PZR) ile viral DNA veya RNA'nın gösterile-memesi bu teoriyi zayıflatmaktadır.…”

Nosocomial Kikuchi's Disease - A Search for Herpesvirus Sequences in Lymph Node Tissues Using PCR

“…The pathogenesis of this disease has been associated with several infectious agents, mainly viruses [5][6][7][8]. The disorder is self-limiting [8]; tubuloreticular structures are observed in cells [9] and IFN␣-producing cells are seen in the affected area [10,11].…”