Alpha-linolenic acid-loaded oil/water microemulsion: Effects of phase behaviour simulation and environmental stress on phase stabilizing and anti-oxidation capacity

Hou, Mengna; Liu, Tiankuo; Zhang, Bo; Chen, Bo-Ru; Li, Qing; Liu, Xiaoxue; Lu, Chao; Wang, Zhanzhong; Dang, Leping

doi:10.1016/j.foodchem.2018.02.100

Cited by 15 publications

(1 citation statement)

References 36 publications

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“…Hence, the ROS and antioxidant capacity of ALA-loaded microemulsion along with storage time were described in Figures and , respectively. The antioxidant capacity of ALA coherently decreased with the increasing of storage time, which was consistent with the report by Hou et al From this point of view and in combination with the result of O/W microemulsion, as we expected, the ROS of ALA in W/O/W microemulsion was slightly decreased in contrast to O/W microemulsion. This phenomenon provided further evidence that the ALA-loaded W/O/W microemulsion equipped with a multi-compartment could disperse ALA into multiple water–oily interfaces; after which, internal ALA was exposed with little probability, resulting in increased antioxidant capacity.…”

Section: Resultssupporting

confidence: 92%

Preparation of α-Linolenic-Acid-Loaded Water-in-Oil-in-Water Microemulsion and Its Potential as a Fluorescent Delivery Carrier with a Free Label

Dang

et al. 2018

J. Agric. Food Chem.

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Our previous work has demonstrated that α-linolenic acid (ALA)-loaded oil-in-water (O/W) microemulsion could enhance ALA antioxidant capacity. Meanwhile, we also observed that synthesized microemulsion itself had fluorescence. In this work, we have prepared a multiple water-in-oil-in-water (W/O/W) microemulsion to further enhance ALA antioxidant capacity and activate this delivery carrier application potential with a free label. The compositions of primary water-in-oil (W/ O) microemulsion were obtained using pseudo-ternary phase diagrams, and then W/O/W microemulsion was prepared adopting the "two-step heterotherm method". The conductivity of W/O/W microemulsion was measured to lie between 250.0 and 350.0 μs/cm. The spherical droplets with a mean particle diameter of 10.0−20.0 nm were confirmed by transmission electron microscopy and dynamic light scattering. Nuclear magnetic resonance confirmed that ALA diffused to the multiple water−oily interface simultaneously. In addition, the in vitro release and antioxidant capacity measurements of ALA-loaded W/ O/W microemulsion concluded the sustained-release effect and excellent antioxidant capacity. The fluorescent intensity of W/ O/W microemulsion was markedly increased in comparison to O/W microemulsion. The synthesized microemulsion could lead to important applications and have advantages of a label-free fluorescent carrier for optical imaging purposes.

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Section: Resultssupporting

confidence: 92%