Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders

Mavroudis, Ioannis; Petridis, Foivos; Chatzikonstantinou, Symela; Kazis, Dimitrios

doi:10.1097/wad.0000000000000381

Cited by 18 publications

(17 citation statements)

References 22 publications

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“… 18 The presence of proteins with a pathological structure results in the activation of glial cells in the brain (astroglial and microglial), triggering inflammatory processes, as free oxygen radicals, excitatory amino acids, interleukins, as well as nitric oxide are released. 1 , 18 Additionally, these compounds contribute to the death of neurons and their connections. 1 , 18 Furthermore, there is a loss of cholinergic neurons in the forebrain, there are also changes in the synapses of the cerebral cortex and hippocampus.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 18 Additionally, these compounds contribute to the death of neurons and their connections. 1 , 18 Furthermore, there is a loss of cholinergic neurons in the forebrain, there are also changes in the synapses of the cerebral cortex and hippocampus. 1 , 18 …”

Section: Introductionmentioning

confidence: 99%

“… 1 , 18 Furthermore, there is a loss of cholinergic neurons in the forebrain, there are also changes in the synapses of the cerebral cortex and hippocampus. 1 , 18 …”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16][17] In addition, other proteins with a pathological structure are also involved in the transformations leading to neuronal atrophy in neurodegenerative disorders: alpha-synuclein and nuclear TDP protein 43. 18 The presence of proteins with a pathological structure results in the activation of glial cells in the brain (astroglial and microglial), triggering inflammatory processes, as free oxygen radicals, excitatory amino acids, interleukins, as well as nitric oxide are released. 1,18 Additionally, these compounds contribute to the death of neurons and their connections.…”

Section: Introductionmentioning

confidence: 99%

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The Analysis of Oxidative Stress Markers May Increase the Accuracy of the Differential Diagnosis of Alzheimer’s Disease with and without Depression

Polak-Szabela¹,

Dziembowska²,

Bracha³

et al. 2021

CIA

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Introduction The aim of work is to assess the usefulness of oxidative stress parameters in the differential diagnosis of dementia of the Alzheimer’s type and dementia of the Alzheimer’s type with coexisting depression. Methods The study involved three groups of people: patients with Alzheimer’s disease (AD) (AD; N=27), patients with Alzheimer’s disease and depression (D) (AD+D; N=30), and a control group that consisted of people without dementia and without depression (C; N=24). The assessment of cognitive functioning was carried out using among alia, Auditory Verbal Learning Test and Verbal Fluency Test. Furthermore, we determined the activity of superoxide dismutase (SOD-1) and superoxide anion radical. Results Multiple models with different combinations of independent variables showed that SOD together with Rey delayed recall were the best significant predictors of AD with the area under curve (AUC) of 0.893 (p = 0.001) and superoxide anion radical (O2 •− ) together with verbal fluency – sharp objects were the best significant predictors of AD +D diagnosis with the AUC of 0.689 (p = 0.034). Conclusion This study confirmed the value of neuropsychological diagnosis and analysis of oxidative stress markers in the diagnosis of AD and major depressive disorder (MDD) in the course of AD. The combination of the use of biochemical markers and neuropsychological tests seems particularly important for differential diagnosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 1 , 18 Furthermore, there is a loss of cholinergic neurons in the forebrain, there are also changes in the synapses of the cerebral cortex and hippocampus. 1 , 18 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Analysis of Oxidative Stress Markers May Increase the Accuracy of the Differential Diagnosis of Alzheimer’s Disease with and without Depression

Polak-Szabela¹,

Dziembowska²,

Bracha³

et al. 2021

CIA

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“…A study showed CSF cytokine/chemokine/growth factor profiles in MSA-C and SCA in which pro-inflammatory cytokines like IL-6, GM-CSF, and MCP-1 displayed specific correlation with the disease stage in MSA-C (Yamasaki et al, 2017). Besides, several proteins including calbindin D, amyloid precursor protein (APP), S100B, and synuclein-alpha (α-synuclein) have been ascertained in neurodegenerative diseases such as AD, Huntington's disease (HD), multiple sclerosis, and MSA (Steiner et al, 2011;Stefanits et al, 2014;van Waalwijk van Doorn et al, 2016;Mavroudis et al, 2020). Meanwhile, the investigation of other proteins such as carbonic anhydrase, CD117/c-kit, proganulin, and kallikreins which may play roles in neural circuit development and maintenance, stress response, innate immunity, and aging as well as brain innate immunity may open a new avenue for the study of MSA (Greco et al, 2012;Dukic et al, 2016;Chitramuthu et al, 2017;Gennarini et al, 2017;Hsieh et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Potential Fluid Biomarkers and a Prediction Model for Better Recognition Between Multiple System Atrophy-Cerebellar Type and Spinocerebellar Ataxia

Guo

Zhao

et al. 2021

Front. Aging Neurosci.

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ObjectiveThis study screened potential fluid biomarkers and developed a prediction model based on the easily obtained information at initial inspection to identify ataxia patients more likely to have multiple system atrophy-cerebellar type (MSA-C).MethodsWe established a retrospective cohort with 125 ataxia patients from southwest China between April 2018 and June 2020. Demographic and laboratory variables obtained at the time of hospital admission were screened using Least Absolute Shrinkage and Selection Operator (LASSO) regression and logistic regression to construct a diagnosis score. The receiver operating characteristic (ROC) and decision curve analyses were performed to assess the accuracy and net benefit of the model. Also, independent validation using 25 additional ataxia patients was carried out to verify the model efficiency. Then the model was translated into a visual and operable web application using the R studio and Shiny package.ResultsFrom 47 indicators, five variables were selected and integrated into the prediction model, including the age of onset (AO), direct bilirubin (DBIL), aspartate aminotransferase (AST), eGFR, and synuclein-alpha. The prediction model exhibited an area under the curve (AUC) of 0.929 for the training cohort and an AUC of 0.917 for the testing cohort. The decision curve analysis (DCA) plot displayed a good net benefit for this model, and external validation confirmed its reliability. The model also was translated into a web application that is freely available to the public.ConclusionThe prediction model that was developed based on laboratory and demographic variables obtained from ataxia patients at admission to the hospital might help improve the ability to differentiate MSA-C from spinocerebellar ataxia clinically.

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Vitamin D Inhibits the Early Aggregation of α‐Synuclein and Modulates Exocytosis Revealed by Electrochemical Measurements

Zhang

et al. 2021

Angewandte Chemie

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Alpha-synuclein (a-Syn) localizes at presynaptic terminal and modulates synaptic functions. Increasing evidence demonstrate that a-Syn oligomers, forming at the early of aggregation, are cytotoxic and is thus related to brain neurodegenerative diseases. Herein, we find that vitamin D (VD) can reduce neurocytotoxicity. The reduced neurocytotoxicity might be attributed to the less amount of large-sized a-Syn oligomers inhibited by VD, measured by electrochemical collision at single particle level, which are not observable with traditionally ensembled method. Single-cell amperometry (SCA) results show that VD can recover the amount of neurotransmitter release during exocytosis induced by a-Syn oligomers, further verifying the neuroprotection of VD. Our study reveals the neuroprotective role of VD through inhibiting a-Syn aggregation, which is envisioned to be of great importance in treatment and prevention of the neurodegenerative diseases.

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Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders

Cited by 18 publications

References 22 publications

The Analysis of Oxidative Stress Markers May Increase the Accuracy of the Differential Diagnosis of Alzheimer’s Disease with and without Depression

The Analysis of Oxidative Stress Markers May Increase the Accuracy of the Differential Diagnosis of Alzheimer’s Disease with and without Depression

Potential Fluid Biomarkers and a Prediction Model for Better Recognition Between Multiple System Atrophy-Cerebellar Type and Spinocerebellar Ataxia

Vitamin D Inhibits the Early Aggregation of α‐Synuclein and Modulates Exocytosis Revealed by Electrochemical Measurements

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