Alpinia galanga Extract Inhibits MCF-7/HER2+ Cells by Inducing Apoptosis

Abstract

Background: Cancer is a disease caused by abnormal growth of body tissue cells. Cancer treatment strategy by induce apoptosis and inhibit proliferation.
 Aim: This research aims to examine the anticancer effect of Alpinia galanga extract on MCF-7/HER2+ breast cancer cells. 
 Method: The MTT Assay cytotoxic test was carried out to determine the growth inhibitory activity. Apoptotic assay to determine the activity of compounds in apoptosis, as well as through a structural approach utilizing various virtual platforms to monitor its activity.
 Result: Based on the MTT assay Alpinia galanga extract possessed cytotoxic effect in dose-dependent manner with IC50 value of 330.79 μg/mL. The extract induces apoptosis of MCF-7 cells up to 25.56%.
 Conclusion: It can be concluded that Alpinia galanga extract demonstrated cytotoxic activity toward MCF-7/HER2+ breast through apoptosis induction. This extract had an opportunity to be developed as a potential anticancer agent to overcome breast cancer diseases.

Standarisasi Ekstrak Rimpang Wundu Watu (Alpinia monopleura) dan Aktivitasnya sebagai Antiinflamasi Secara In Vitro

“…Genus Alpinia terutama dikenal sebagai tanaman dan herba etnomedis di banyak negara seperti Indonesia, India, Vietnam, Cina, dan Jepang (Van et al, 2021). Beberapa studi farmakologi Alpinia telah dilaporkan memiliki berbagai bioaktivitas seperti aktivitas antikanker (Ibrahim, 2022;Lintao & Medina, 2021) aktivitas antioksidan, aktivitas antimikroba (Cruz et al, 2020;Ferdous et al, 2018), aktivitas anti inflamasi (Yu et al, 2020), dan aktivitas analgesik (Ahmed & Kumar, 2022).…”

Essential Oils of Alpinia monopleura and Their Antibacterial and Antioxidant Activity

“…Alpinia genus is mainly known as an ethnomedicinal plant and herb in many countries such as Indonesia, India, Vietnam, China, and Japan (Van et al, 2021). Several pharmacological studies of Alpinia have been reported, and they have various bioactivities such as anticancer activity (Ibrahim, 2022;Lintao & Medina, 2021), antioxidant activity, antimicrobial activity (Cruz et al, 2020;Ferdous et al, 2018), antiviral activity (Hatanaka et al, 2021;Narusaka et al, 2021;Zubair et al, 2021), antiinflammatory activity, anti-nociceptive activity (Yu et al, 2020), antiparasitic activity (Sulistyowaty et al, 2021), neuroprotection activity (Hashim et al, 2021;Mundugaru et al, 2018), antihypertensive activity (Moura et al, 2005) and analgesics activity (Ahmed et al, 2015).…”