Alprazolam in the Treatment of Cardiology Patients with Atypical Chest Pain and Panic Disorder

Beitman, Bernard D.; Basha, Imad; Trombka, L H; Jayaratna, M A; Russell, B D; Tarr, Sukey

doi:10.1097/00004714-198804000-00009

Cited by 22 publications

(6 citation statements)

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“…There is need for controlled studies to evaluate whether treatment of mental disorders reduces the functional disability and improves the quality of life in NCCP patients. Reports from pilot studies about the efficacy of alprazolam in NCCP patients is encouraging (18).…”

Section: Discussionmentioning

confidence: 99%

Mental disorders in patients with noncardiac chest pain

Alexander

Prabhu

Krishnamoorthy

et al. 1994

Acta Psychiatr Scand

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About 70% of noncardiac chest pain (NCCP) patients have mental disorders as reported from Western countries. The phenomenon of somatization is considered to be aetiologically important in the genesis of NCCP. Though somatization is generally considered as more prevalent among non-Western cultures, systematic studies of mental disorder among NCCP patients are rare from developing countries. Based on treadmill test, 54 male inpatients in a cardiology general ward in India were divided into a group having ischaemic heart disease (IHD) and another group of NCCP. A psychiatric interview was conducted blindly on these subjects with the help of a structured interview schedule, and DSM-III-R diagnosis was made. Sixty-eight percent in the NCCP group and 27% in the IHD group had a mental disorder. The total number of subjects with a mental disorder, including panic disorder and major depression, were significantly more in the NCCP group. Mental disorders appears to be equally common among NCCP patients in developing countries also and detailed psychiatric assessment is warranted in patients with chest pain of non-IHD origin.

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Section: Discussionmentioning

confidence: 99%

Mental disorders in patients with noncardiac chest pain

Alexander

Prabhu

Krishnamoorthy

et al. 1994

Acta Psychiatr Scand

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“…A minority of patients with major depression respond well to antidepressants. An uncontrolled trial of alprazolam (Beitman et al 1988) reported improvement in subjects with both atypical chest pain and panic disorder. A number of writers have suggested behavioural rehabilitation (Levenkron et al 1985;Lantinga et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Psychological treatment for atypical non-cardiac chest pain: a controlled evaluation

et al. 1990

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SynopsisThirty-one patients with atypical non-cardiac chest pain which had persisted despite negative medical investigation were treated in a controlled trial of cognitive-behavioural therapy. The average duration of pain was 4·7 years. Patients were randomized to either immediate treatment or as a control to assessment only. Treatment involved teaching patients how to anticipate and control symptoms, and modification of inappropriate health beliefs. The average number of sessions given was 7·2. There were significant reductions in chest pain, limitations and disruption of daily life, autonomic symptoms, distress and psychological morbidity in the treated group as compared with the control group who were unchanged. The assessment-only group were treated subsequently and showed comparable changes. Improvements were fully maintained by both treated groups at four to six-months follow-up.

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“…Several psychoactive agents demonstrate some efficacy, possibly to a greater extent than smooth muscle agents. These include benzodiazepines, tricyclics, and trazodone [14,22,23].…”

Section: Therapymentioning

confidence: 99%