ALSSAT Development Status and Its Applications in Trade Studies

Yeh, H. Y.; Brown, Christine Ann; Jeng, Frank F.; Lin, Chong; Ewert, Michael K.

doi:10.4271/2004-01-2438

Cited by 6 publications

References 12 publications

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Microbial biomanufacturing for space-exploration—what to take and when to make

et al. 2023

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As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase resilience, flexibility, and efficiency of missions, by virtue of its ability to effectively utilize in situ resources and reclaim resources from waste streams. Here we outline four primary mission-classes on Moon and Mars that drive a staged and accretive biomanufacturing strategy. Each class requires a unique approach to integrate biomanufacturing into the existing mission-architecture and so faces unique challenges in technology development. These challenges stem directly from the resources available in a given mission-class—the degree to which feedstocks are derived from cargo and in situ resources—and the degree to which loop-closure is necessary. As mission duration and distance from Earth increase, the benefits of specialized, sustainable biomanufacturing processes also increase. Consequentially, we define specific design-scenarios and quantify the usefulness of in-space biomanufacturing, to guide techno-economics of space-missions. Especially materials emerged as a potentially pivotal target for biomanufacturing with large impact on up-mass cost. Subsequently, we outline the processes needed for development, testing, and deployment of requisite technologies. As space-related technology development often does, these advancements are likely to have profound implications for the creation of a resilient circular bioeconomy on Earth.

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Microbial biomanufacturing for space-exploration—what to take and when to make

et al. 2023

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Theoretical design of a space bioprocessing system to produce recombinant proteins

Soundararajan,

Paddock,

Dougherty

et al. 2023

npj Microgravity

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Space-based biomanufacturing has the potential to improve the sustainability of deep space exploration. To advance biomanufacturing, bioprocessing systems need to be developed for space applications. Here, commercial technologies were assessed to design space bioprocessing systems to supply a liquid amine carbon dioxide scrubber with active carbonic anhydrase produced recombinantly. Design workflows encompassed biomass dewatering of 1 L Escherichia coli cultures through to recombinant protein purification. Non-crew time equivalent system mass (ESM) analyses had limited utility for selecting specific technologies. Instead, bioprocessing system designs focused on minimizing complexity and enabling system versatility. Three designs that differed in biomass dewatering and protein purification approaches had nearly equivalent ESM of 357–522 kg eq. Values from the system complexity metric (SCM), technology readiness level (TRL), integration readiness level (IRL), and degree of crew assistance metric identified a simpler, less costly, and easier to operate design for automated biomass dewatering, cell lysis, and protein affinity purification.

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A Testbed for Evaluating Lunar Habitat Autonomy Architectures

Kortenkamp

Izygon²,

Lawler

et al. 2008

AIP Conference Proceedings

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Abstract.A lunar outpost will involve a habitat with an integrated set of hardware and software that will maintain a safe environment for human activities. There is a desire for a paradigm shift whereby crew will be the primary mission operators, not ground controllers. There will also be significant periods when the outpost is uncrewed. This will require that significant automation software be resident in the habitat to maintain all system functions and respond to faults. JSC is developing a testbed to allow for early testing and evaluation of different autonomy architectures. This will allow evaluation of different software configurations in order to: 1) understand different operational concepts; 2) assess the impact of failures and perturbations on the system; and 3) mitigate software and hardware integration risks. The testbed will provide an environment in which habitat hardware simulations can interact with autonomous control software. Faults can be injected into the simulations and different mission scenarios can be scripted. The testbed allows for logging, replaying and reinitializing mission scenarios. An initial testbed configuration has been developed by combining an existing life support simulation and an existing simulation of the space station power distribution system. Results from this initial configuration will be presented along with suggested requirements and designs for the incremental development of a more sophisticated lunar habitat testbed.

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ALSSAT Development Status and Its Applications in Trade Studies

Cited by 6 publications

References 12 publications

Microbial biomanufacturing for space-exploration—what to take and when to make

Microbial biomanufacturing for space-exploration—what to take and when to make

Theoretical design of a space bioprocessing system to produce recombinant proteins

A Testbed for Evaluating Lunar Habitat Autonomy Architectures

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