Alterações do perfil lipídico nas anemias

Naoum, Flávio Augusto

doi:10.1590/s1516-84842005000300018

Cited by 6 publications

(10 citation statements)

References 23 publications

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“…Cholesterol plays an important role in cellular metabolism, including cell membrane synthesis; membranes are comprised of 52% proteins, 40% phospholipids and cholesterol, and 8% carbohydrates (23). Low plasma levels of cholesterol have been reported in several types of acquired and hereditary hematological disorders, including megaloblastic anemia, iron deficiency anemia, aplastic anemia, anemia associated with liver disease, hereditary spherocytosis, SCA, and thalassemia (4).…”

Section: Discussionmentioning

confidence: 99%

Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia

Teixeira

Arriaga

Terse-Ramos

et al. 2019

Braz J Med Biol Res

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Dyslipidemia has been described in sickle cell anemia (SCA) but its association with increased disease severity is unknown. Here, we examined 55 children and adolescents with SCA as well as 41 healthy controls to test the association between the lipid profiles in peripheral blood and markers of hemolysis, inflammation, endothelial function, and SCA-related clinical outcomes. SCA patients exhibited lower levels of total cholesterol (P<0.001), low-density lipoprotein cholesterol (LDL-c) (P<0.001), and high-density lipoprotein cholesterol (HDL-c) (P<0.001), while displaying higher triglyceride (TG) levels and TG/HDL-c ratio values (P<0.001). TG/HDL-c values were positively correlated with lactate dehydrogenase (P=0.047), leukocyte count (P=0.006), and blood flow velocity in the right (P=0.02) and left (P=0.05) cerebral artery, while being negatively correlated with hemoglobin levels (P<0.04). Acute chest syndrome (ACS) and vaso-occlusive events (VOE) were more frequent in SCA patients exhibiting higher TG/HDL-c values (odds ratio: 3.77, P=0.027). Multivariate logistic regression analysis confirmed independent associations between elevated TG/HDL-c values and SCA. Thus, children and adolescents with SCA exhibited a lipid profile associated with hemolysis and inflammatory parameters, with increased risk of ACS and VOE. TG/HDL-c is a potential biomarker of severity of disease.

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Section: Discussionmentioning

confidence: 99%

Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia

Teixeira

Arriaga

Terse-Ramos

et al. 2019

Braz J Med Biol Res

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“…T. congolense, T. brucei and T. evansi use glucose as well as triglycerides and cholesterol from the host as energy sources (COPPENS et al, 1995;KATUNGUKA-RWAKISHAYA et al, 1997). Low cholesterol levels are often found in many types of anemia due to greater use of plasmatic cholesterol determined by the replacement of erythrocyte lipids in cases of increased hemolysis (NAOUM, 2005).…”

Section: Evaluation Of Cattle Experimentally Infected With T Vivaxmentioning

confidence: 99%

Evaluation of clinical signs, parasitemia, hematologic and biochemical changes in cattle experimentally infected with Trypanosoma vivax

Fidélis

Sampaio

Machado

et al. 2016

Rev. Bras. Parasitol. Vet.

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Infections by Trypanosoma vivax cause great losses to livestock in Africa and Central and South Americas. Outbreaks due this parasite have been occurred with increasing frequency in Brazil. Knowledge of changes caused by T. vivax during the course of this disease can be of great diagnostic value. Thus, clinical signs, parasitemia, hematologic and biochemical changes of cattle experimentally infected by this hemoparasite were evaluated. Two distinct phases were verified during the infection -an acute phase where circulating parasites were seen and then a chronic phase where fluctuations in parasitemia were detected including aparasitemic periods. A constant reduction in erythrocytes, hemoglobin and packed cell volume (PVC) were observed. White blood cells (WBC) showed pronounced changes such as severe neutropenia and lymphopenia during the acute phase of the illness. Decreases in cholesterol, albumin, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and increases in glucose, globulin, protein, and alkaline phosphatase (ALP) were observed. The "Lins" isolate of T. vivax showed pathogenicity for cattle, and intense parasitemia was detected in the early stages of infection. Circulating parasites were detected for about two months. The most evident laboratory abnormalities were found in WBC parameters, including thrombocytopenia.Keywords: Trypanosomiasis, bovine, host-parasite relationship, complete blood count. ResumoInfecções pelo Trypanosoma vivax causam grandes prejuízos à pecuária na África e Américas Central e do Sul. Surtos devido a este protozoário têm ocorrido com frequência cada vez maior no Brasil. O conhecimento das alterações provocadas pelo T. vivax durante a evolução desta enfermidade podem ser de grande valia para o auxílio no diagnóstico. Para tanto foram estudados os sinais clínicos, parasitemia, alterações hematológicas e bioquímicas em bovinos experimentalmente infectados por este hemoparasito. Foram verificadas duas fases distintas durante a infecção, uma aguda onde parasitos circulantes foram vistos durante todo o período, e posteriormente uma crônica, onde foram detectadas flutuações na parasitemia, com períodos aparasitêmicos. Foi verificada constante diminuição da contagem global de eritrócitos, teor de hemoglobina e volume globular (VG). O leucograma revelou leucopenia por neutropenia e linfopenia durante a fase aguda da enfermidade. Foram observados diminuição do colesterol, albumina, aspartato aminotransferase (AST), lactato desidrogenase (LDH) e aumento da glicose, globulinas, proteínas e fosfatase alcalina (FA). O isolado "Lins" de T. vivax apresentou patogenicidade para bovinos, verificando-se parasitemia intensa nos estágios iniciais da infecção, sendo detectados parasitas circulantes por aproximadamente dois meses. As alterações laboratoriais mais evidentes foram encontradas nos parâmetros do leucograma, ainda destacando-se um quadro de trombocitopenia.Palavras-chave: Tripanossomíase, bovino, relação parasita-hospedeiro, hemograma.

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“…Individuals with anemia had a lower prevalence of high LDL-cholesterol. Low plasma cholesterol values are described in several types of acquired and hereditary anemias (megaloblastic, iron deficiency, aplastic, associated with liver disease, hereditary spherocytosis, sickle cell, and thalassemia) 40 , which is due to the greater use of plasma cholesterol, determined by the renewal of erythrocyte lipids in cases of lower survival or increased hemolysis and the more significant dilution of serum cholesterol due to the increase in plasma volume secondary to low hematocrit and hemoglobin values 40 . In sickle cell anemia and thalassemia, the hepatic dysfunction reduces endogenous cholesterol production and increases the lipid profile changes in patients with low TC, LDL, and HDL levels 40 .…”

Section: Discussionmentioning

confidence: 99%

“…In this analysis, the PR adj b were estimated, and the explanatory variables that presented a value of p ≤ 0.05 were considered as factors associated with high LDL-cholesterol. Confounding variables were tested considering aspects of the literature 8,15,16,[19][20][21][38][39][40][41][42] .…”

Section: Methodsmentioning

confidence: 99%

Fatores associados ao LDL-Colesterol aumentado na população adulta brasileira: Pesquisa Nacional de Saúde

Sá

Machado

Bernal

et al. 2021

Ciênc. saúde coletiva

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Resumo O estudo analisou os fatores associados ao LDL-Colesterol aumentado na população adulta brasileira. Estudo transversal com dados laboratoriais de 8.534 indivíduos coletados na Pesquisa Nacional de Saúde. Calculadas as prevalências de LDL-Colesterol <130 e ≥130 mg/dL. A variável desfecho foi LDL-Colesterol aumentado (≥130 mg/dL) e as variáveis explicativas foram sociodemográficas, antropométricas, estilo de vida, doenças crônicas e autoavaliação de saúde. Para verificar as associações, utilizou-se regressão de Poisson e estimou-se as razões de prevalência (RP) e intervalos de confiança (IC) 95%. A prevalência de LDL-Colesterol aumentado foi 18,58%. No modelo final multivariado associaram-se ao desfecho: idade entre 30 a 44 anos (RP 1,99; IC 1,58-2,54), 45 a 59 anos (RP 2,89; IC 2,29-3,64) e 60 anos ou mais (RP 2,90; IC 2,29-3,68), região Nordeste (RP 1,16; IC 1,02-1,32), sobrepeso (RP 1,32; IC 1,15-1,51), obesidade (RP 1,41; IC 1,19-1,65) ou anemia (RP 0,66; IC 0,54-0,80). O LDL-Colesterol aumentado associou-se ao envelhecimento, sobrepeso, obesidade, morar na região Nordeste e ter anemia. Monitorar os níveis de LDL é importante, pelo risco aumentado com envelhecimento, para orientar ações de estilos de vida saudáveis e diagnóstico em locais de menor acesso.

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Alterações do perfil lipídico nas anemias

Abstract: Naoum FA Rev. bras. hematol. hemoter. 2005;27(3):223-226 Educacional/ Educational Alterações do perfil lipídico nas anemias Alterations of the lipid profile in anemia

Cited by 6 publications

References 23 publications

Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia

Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia

Evaluation of clinical signs, parasitemia, hematologic and biochemical changes in cattle experimentally infected with Trypanosoma vivax

Fatores associados ao LDL-Colesterol aumentado na população adulta brasileira: Pesquisa Nacional de Saúde

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