Alteration in auditory function during the ovarian cycle

Al-Mana, Deena; Ćeranić, Borka; Djahanbakhch, O.; Luxon, Linda M.

doi:10.1016/j.heares.2010.05.007

Cited by 45 publications

(46 citation statements)

References 64 publications

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“…There are previous literature reports demonstrating increased hearing sensitivity in the menstrual cycle during periods of high estrogen (i.e. proestrus) (Al-Mana, et al, 2010), which are analogous to the results shown here.…”

Section: Discussionsupporting

confidence: 90%

Behavioral effects and mechanisms of migraine pathogenesis following estradiol exposure in a multibehavioral model of migraine in rat

Vermeer

Gregory

Winter

et al. 2015

Experimental Neurology

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Migraine is one of the most common neurological disorders, leading to more than 1% of total disability reported and over 68 million visits to emergency rooms or physician’s offices each year in the United States. Three times as many women as men have migraine, and while the mechanism behind this is not well understood, 17β-estradiol (estradiol) has been implicated to play a role. Studies have demonstrated that exposure to estrogen can lead to activation of inflammatory pathways, changes in sodium gated channel activity, as well as enhanced vasodilation and allodynia. Estradiol receptors are found in trigeminal nociceptors, which are involved in signaling during a migraine attack. The purpose of this study was to investigate the role of estradiol in migraine pathogenesis utilizing a multibehavioral model of migraine in rat. Animals were surgically implanted with a cannula system to induce migraine and behavior was assessed following exposure to a proestrous level of estradiol for total locomotor activity, light and noise sensitivity, evoked grooming patterns, and enhanced acoustic startle response. Results demonstrated decreased locomotor activity, increased light and noise sensitivity, altered facial grooming indicative of allodynia and enhanced acoustic startle. Further examination of tissue samples revealed increased expression of genes associated with inflammation and vasodilation. Overall, this study demonstrates exacerbation of migraine-like behaviors following exposure to estradiol and helps further explain the underlying mechanisms behind sex differences found in this common neurological disorder.

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Section: Discussionsupporting

confidence: 90%

Behavioral effects and mechanisms of migraine pathogenesis following estradiol exposure in a multibehavioral model of migraine in rat

Vermeer

Gregory

Winter

et al. 2015

Experimental Neurology

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“…If ultrasonic calls prove to be a cue that female hamsters use in mate selection, then an age-related decline in auditory processing could contribute to a reduced ability to distinguish between dominant and subordinate males. Hormones also modulate auditory processing in mammals (Al-Mana et al, 2010;Miranda and Liu, 2009), and it is conceivable that hormonal profiles differed in young and old hamsters, even though both age classes were cycling regularly and were tested on the same day of the oestrous cycle. Saidapur and Greenwald (1978) noted substantial variation in sex steroid concentrations during pro-oestrus in adult hamsters (presumably young), and future studies comparing the mating preferences of young and old hamsters should include assessments of hormones and receptors that are known to modulate auditory processing (e.g., oestradiol).…”

Section: Discussionmentioning

confidence: 99%

Reduced mate preference for dominant over subordinate males in old female Syrian hamsters (Mesocricetus auratus)

Place

Vernon

Johnston

2014

Behavioural Processes

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“…For example, in humans, fluctuations in auditory perception (Haggard and Gaston, 1978; Cowell et al, 2011) and in electrophysiological measures of auditory function (Walpurger et al, 2004; Al-Mana et al, 2010) during the menstrual cycle highlight the effects of estrogen on auditory processing. When estradiol levels are exogenously modified, alterations in auditory perception, auditory brainstem latencies, auditory thresholds, and sound localization are observed (Haggard and Gaston, 1978; Jerger and Johnson, 1988; Wharton and Church, 1990; Coleman et al, 1994; Caruso et al, 2003).…”

Section: Estrogen Modulates Auditory Neural Pathwaysmentioning

confidence: 99%

Sexual attractiveness of male chemicals and vocalizations in mice

Asaba¹,

Hattori²,

Mogi³

et al. 2014

Front. Neurosci.

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Male-female interaction is important for finding a suitable mating partner and for ensuring reproductive success. Male sexual signals such as pheromones transmit information and social and sexual status to females, and exert powerful effects on the mate preference and reproductive biology of females. Likewise, male vocalizations are attractive to females and enhance reproductive function in many animals. Interestingly, females' preference for male pheromones and vocalizations is associated with their genetic background, to avoid inbreeding. Moreover, based on acoustic cues, olfactory signals have significant effects on mate choice in mice, suggesting mate choice involves multisensory integration. In this review, we synopsize the effects of both olfactory and auditory cues on female behavior and neuroendocrine functions. We also discuss how these male signals are integrated and processed in the brain to regulate behavior and reproductive function.

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Alteration in auditory function during the ovarian cycle

Cited by 45 publications

References 64 publications

Behavioral effects and mechanisms of migraine pathogenesis following estradiol exposure in a multibehavioral model of migraine in rat

Behavioral effects and mechanisms of migraine pathogenesis following estradiol exposure in a multibehavioral model of migraine in rat

Reduced mate preference for dominant over subordinate males in old female Syrian hamsters (Mesocricetus auratus)

Sexual attractiveness of male chemicals and vocalizations in mice

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