Alteration of carotid occlusion response by anesthesia

Armstrong, George G.; Porter, Hugh; Langston, Jimmy B.

doi:10.1152/ajplegacy.1961.201.5.897

Cited by 39 publications

(15 citation statements)

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“…Consistent with these findings is the report by Armstrong, Porter & Langston (1961), that the pressor response to carotid occlusion in conscious dogs was augmented by chloralose and depressed by urethane and barbiturates. Although the cause of these changes is not known, the present experiments suggest an effect of the anaesthetic on cardiovascular responsiveness to sympathetic stimulation rather than an effect on the neural pathways of the baroreceptor mechanism.…”

Section: Discussionsupporting

confidence: 88%

Cardiovascular responses to noradrenaline in the rat before and after administration of various anaesthetics

Brezenoff

1973

British J Pharmacology

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Summary1. Cardiovascular responses to intravenously administered noradrenaline were monitored in the rat in the conscious state and again following anaesthesia. Injections and pressure recordings were made via permanently implanted venous and arterial catheters. 2. The pressor response to noradrenaline was inhibited by diethyl ether, urethane and deep pentobarbitone anaesthesia. It was unchanged by ketamine and was potentiated by chloralose and light pentobarbitone anaesthesia. 3. Reflex bradycardia was potentiated by chloralose, blocked by ketamine and reduced by pentobarbitone. It was either reduced or unchanged by ether or urethane.

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Section: Discussionsupporting

confidence: 88%

Cardiovascular responses to noradrenaline in the rat before and after administration of various anaesthetics

Brezenoff

1973

British J Pharmacology

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“…However, the peak mean arterial pressure increase and the peak heart-rate decrease were greater before chloralose than before pentobarbitone Na. These results suggest that baroreceptors may be overactive under chloralose anaesthesia (Brown & Hilton, 1956;Armstrong, Porter & Langston, 1961) and underactive under pentobarbitone Na anaesthesia (Cox, 1972a). Cox (1972a) noticed that pentobarbitone Na reduced the increase in heart rate and output caused by isoprenaline.…”

Section: Discussionmentioning

confidence: 97%

Influence of Chloralose and Pentobarbitone Sodium on Atrioventricular Conduction in Dogs

Duchêne-Marullaz¹,

Fabry-Delaigue²,

Gueorguiev³

et al. 1982

British J Pharmacology

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Atrial pacing at progressively increasing frequencies was performed on unanaesthetized dogs through electrodes placed aseptically in the wall of the right atrium and exteriorized in the neck region. Heart rate and two atrioventricular conduction (AVC) parameters, namely the Wenckebach Point (one or two systole block at the end of expiration)‐and the maximum atrioventricular conduction frequency (the frequency of pacing for which ventricles do not follow any auricular stimulation) were measured by electrocardiography. Chloralose (0.08 g/kg i.v.) did not affect either heart rate or AVC but significantly reduced the effect of atropine (0.1 mg/kg i.v.) on all three parameters measured. The effect of isoprenaline (0.25 μg kg−1 min−1) remained unchanged. Pentobarbitone Na (25 mg/kg i.v.) increased heart rate and usually caused the Wenckebach Point to disappear. It reduced the effects of atropine but did not modify those of isoprenaline. In view of these results we suggest that pentobarbitone Na be avoided as an anaesthetic agent in AVC studies. It is possible to dispense with an anaesthetic agent if the technique described here is used.

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“…Armstrong et al (27) reported a lower heart rate. Cardiac output has been reported to range from an increase with (1 9) or without (25, 26) tachycardia, variable changes over time (1 1, 18), a decrease (18,21), and no effect (7).…”

Section: Pulmonary Vascular Resistancementioning

confidence: 95%

“…Study conditions have ranged from mechanical (7, 18, 19,2 1-23,28) to spontaneous ventilation (1 1, 20, 24-27) and from acute (18,19,28) to chronic instrumentation (7, l l , [20][21][22][23][24][25][26][27]. Moreover, studies have used different doses of chloralose, various supplemental solvents or anesthetic agents, and different species and ages of animals.…”

Section: Pulmonary Vascular Resistancementioning

confidence: 99%

Chloralose Alters Both Basal Hemodynamics and Cardiovascular Responses to Alveolar Hypoxia in Chronically Instrumented, Spontaneously Breathing Lambs'

et al. 1989

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ABSTRACT. We studied the effects of chloralose anesthesia on the basal hemodynamic state and on the cardiovascular response to alveolar hypoxia in chronically instrumented, spontaneously breathing lambs, compared with responses to the saline vehicle. Chloralose significantly increased heart rate (23%), mean systemic arterial pressure (]I%), systemic vascular resistance (21%), mean pulmonary arterial pressure (23%), and pulmonary vascular resistance (46%) (n = 30, p < 0.05, ANOVA). These changes were unrelated to baseline tone of the circulation, cardiac output, mean left atrial pressure, or physiologically important changes in arterial blood gas tensions. In addition, chloralose-treated lambs had increased heart rate, systemic vascular resistance, and pulmonary vascular resistance compared to controls during alveolar hypoxia (13-15% FiOz). Importantly, chloralose-treated lambs did not increase their cardiac output during alveolar hypoxia a s did control lambs. During hypoxia, systemic vascular resistance remained elevated in chloralose-treated lambs, but declined in control lambs. Chloralose has been recommended a s an ideal anesthetic agent for cardiovascular experimentation. Our data suggest that chloralose-induced alterations in basal hemodynamics and in cardiovascular responses to alveolar hypoxia represent an uncontrolled variable in acute experimental studies. Complex cardiovascular alterations caused by anesthesia should be considered in experimental design. (Pediatr Res 25389-395, 1989) Abbreviations PVR, pulmonary vascular resistance SVR, systemic vascular resistance

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Alteration of carotid occlusion response by anesthesia

Cited by 39 publications

References 0 publications

Cardiovascular responses to noradrenaline in the rat before and after administration of various anaesthetics

Cardiovascular responses to noradrenaline in the rat before and after administration of various anaesthetics

Influence of Chloralose and Pentobarbitone Sodium on Atrioventricular Conduction in Dogs

Chloralose Alters Both Basal Hemodynamics and Cardiovascular Responses to Alveolar Hypoxia in Chronically Instrumented, Spontaneously Breathing Lambs'

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