Alteration of chemical behavior of L–ascorbic acid in combination with nickel sulfate at different pH solutions in vitro

Maniyar, Shaheen A; Jargar, Jameel G.; Das, Swastika; Dhundasi, Salim A; Das, Kusal K.

doi:10.1016/s2221-1691(12)60045-8

Cited by 16 publications

(5 citation statements)

References 7 publications

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“…Therefore, the degradation rate of ASC and its exponential effect on RIF were evaluated at different release media. As shown in Figure 8a,b, the UV spectrum of ASC at two different pHs showed one maximum at 276 nm, which became broader and shifted toward the red region (bathochromic effect), particularly after 24 h. It is in agreement with Maniyar, et al, who clearly indicated an altered chemical behavior of ASC at different pH values [48]. These changes are more obvious at alkaline pH due to the greater oxidation of ASC (Figure 8b).…”

Section: Degradation Studiessupporting

confidence: 86%

Nanoparticle-Based Rifampicin Delivery System Development

et al. 2021

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The alkaline milieu of chronic wounds severely impairs the therapeutic effect of antibiotics, such as rifampicin; as such, the development of new drugs, or the smart delivery of existing drugs, is required. Herein, two innovative polyelectrolyte nanoparticles (PENs), composed of an amphiphilic chitosan core and a polycationic shell, were synthesized at alkaline pH, and in vitro performances were assessed by 1H NMR, elemental analysis, FT-IR, XRD, DSC, DLS, SEM, TEM, UV/Vis spectrophotometry, and HPLC. According to the results, the nanostructures exhibited different morphologies but similar physicochemical properties and release profiles. It was also hypothesized that the simultaneous use of the nanosystem and an antioxidant could be therapeutically beneficial. Therefore, the simultaneous effects of ascorbic acid and PENs were evaluated on the release profile and degradation of rifampicin, in which the results confirmed their synergistic protective effect at pH 8.5, as opposed to pH 7.4. Overall, this study highlighted the benefits of nanoparticulate development in the presence of antioxidants, at alkaline pH, as an efficient approach for decreasing rifampicin degradation.

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Section: Degradation Studiessupporting

confidence: 86%

Nanoparticle-Based Rifampicin Delivery System Development

et al. 2021

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“…However, AA absorbance at 260 nm increased in accordance with Zn 2+ concentration in PBS. Similarly, Maniyar et al (2012) reported that the absorbance of AA in solution containing nickel sulfate at pH 7.0 and 7.4 was higher than the absorbance of AA alone. Thus, the absorbance of an AA–metal chelate complex is most likely more pronounced than that of unchelated AA at the culture medium pH.…”

Section: Discussionmentioning

confidence: 90%

Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

et al. 2017

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Exposure to zinc oxide nanoparticles (ZnO NPs) promotes acute pulmonary toxicity through oxidative stress and inflammation. Furthermore, dissolved zinc from ZnO NPs induces the formation of intracellular reactive oxygen species (ROS). We previously reported that supplemental ascorbic acid (AA) inhibits ZnO NP-induced acute pulmonary toxicity in a rat model; however, the mechanism of this action remains unclear. Therefore, we investigated the effects of AA on ZnO NP-induced cytotoxicity in human lung carcinoma A549 cells. AA was found to suppress intracellular production of ROS, and thus reduce the subsequent inflammation of ZnO NPs. However, intracellular Zn concentrations were higher in AA-treated cells than in AA-untreated cells. AA was found to react with Zn but not with the ZnO NPs themselves. These results suggest the possibility that AA-chelated extracellular Zn and the Zn-AA complex was readily taken up into cell. Even if the intracellular Zn level was high, cytotoxicity might be reduced because the Zn-AA complex was stable. Co-treatment of AA to A549 inhibited ROS production and subsequent intracellular inflammatory responses. These results are consistent with those previously reported from an in vivo model. Thus, two possibilities can be considered about the cytotoxicity-reducing the effect of AA: antioxidant efficacy and chelating effect.

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“…A similar reaction is known to also occur with Ni [28], hence, the observed progressive increases in metal (Ni, Co, Li) recovery with increased concentrations of ascorbic acid. In addition, the measured drop in system ORP is the result of the negative reduction potentials related to the dissociation of ascorbate species in aqueous solutions, which are enhanced with higher concentrations of ascorbic acid in solution [30].…”

Section: Leaching In Sulfuric Acid With Different Reducing Agentsmentioning

confidence: 99%

Leaching of Metals from Spent Lithium-Ion Batteries

et al. 2017

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Abstract:The recycling of valuable metals from spent lithium-ion batteries (LIBs) is becoming increasingly important due to the depletion of natural resources and potential pollution from the spent batteries. In this work, different types of acids (2 M citric (C 6 H 8 O 7 ), 1 M oxalic (C 2 H 2 O 4 ), 2 M sulfuric (H 2 SO 4 ), 4 M hydrochloric (HCl), and 1 M nitric (HNO 3 ) acid)) and reducing agents (hydrogen peroxide (H 2 O 2 ), glucose (C 6 H 12 O 6 ) and ascorbic acid (C 6 H 8 O 6 )) were selected for investigating the recovery of valuable metals from waste LIBs. The crushed and sieved material contained on average 23% (w/w) cobalt, 3% (w/w) lithium, and 1-5% (w/w) nickel, copper, manganese, aluminum, and iron. Results indicated that mineral acids (4 M HCl and 2 M H 2 SO 4 with 1% (v/v) H 2 O 2 ) produced generally higher yields compared with organic acids, with a nearly complete dissolution of lithium, cobalt, and nickel at 25 • C with a slurry density of 5% (w/v). Further leaching experiments carried out with H 2 SO 4 media and different reducing agents with a slurry density of 10% (w/v) show that nearly all of the cobalt and lithium can be leached out in sulfuric acid (2 M) when using C 6 H 8 O 6 as a reducing agent (10% g/g scraps ) at 80 • C.

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Alteration of chemical behavior of L–ascorbic acid in combination with nickel sulfate at different pH solutions in vitro

Cited by 16 publications

References 7 publications

Nanoparticle-Based Rifampicin Delivery System Development

Nanoparticle-Based Rifampicin Delivery System Development

Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

Leaching of Metals from Spent Lithium-Ion Batteries

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