Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

Fukui, Hitoshi; Iwahashi, Hitoshi; Nishio, Keiko; Hagihara, Yoshihisa; Yoshida, Yasukazu; Horie, Masanori

doi:10.1177/0748233717707361

Cited by 16 publications

(13 citation statements)

References 35 publications

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“…As‐2P displayed slightly better effect than L‐AA, which was consistent with its stability in solution. As‐2P may exert its effect within the cells or by modifying the extracellular environment (Fukui et al, ). As‐2P can be taken up by cells through sodium‐dependent Vc transporters (SVCTs) after modification by cell membrane esterases (Du et al, ).…”

Section: Resultsmentioning

confidence: 99%

Vitamin C promotes oligodendrocytes generation and remyelination

Guo

Suo

Cui

et al. 2018

Glia

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Oligodendrocyte‐formed myelin sheaths play important roles in the neuronal functions in the central nervous system. In demyelinating diseases, such as Multiple Sclerosis, the myelin sheaths are damaged and the remyelinating process is somehow hindered. Restoration of the myelin sheaths requires the differentiation of the oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs). To discover small molecule compounds that might promote the OPC to OL differentiation, a high‐throughput screening system is established and L‐ascorbyl‐2‐phosphate (As‐2P), a stable form of Vitamin C (Vc), is found to greatly enhance the OPC to OL differentiation. As‐2P promotes gradual expression of OL lineage markers, including O4, CNPase and MBP, in a dose‐ and time‐dependent manner. It also facilitates the formation of myelin sheaths in OPC‐neuron co‐culture. As‐2P also promotes the repair of the myelin sheaths in vivo and provides significant therapeutic effect in a cuprizone‐mediated demyelination animal model. Interestingly, As‐2P's function in promoting OPC differentiation is not related to its antioxidant activity. And an intracellular rather than an extracellular mechanism might be involved. Considering the safe use of Vc as a dietary supplement for many years, it might also be used as an alternative medicine for CNS demyelinating diseases.

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Section: Resultsmentioning

confidence: 99%

Vitamin C promotes oligodendrocytes generation and remyelination

Guo

Suo

Cui

et al. 2018

Glia

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“…The current study was designed to determine the possible toxic effect of chronic oral administration of environmental-equivalent doses of pulmonary toxicity induced by ZnO-NPs. It was proved recently that, the mechanisms underlying the toxicity of ZnO-NPs depend on the induction of apoptosis [23,24]. Significant increase in the levels of pro-inflammatory mediator (COX-2) in lung tissue indicated pulmonary damage.…”

Section: Discussionmentioning

confidence: 99%

“…Qiao et al provided evidence that the pulmonary inflammation induced by exposure to ZnO-NPs is through modulation of miRNA expression [27]. Fukui et al reported that the inflammatory response and also the oxidative stress induced by ZnO-NPs were prevented by co-treatment with ascorbic acid in human lung carcinoma A549 cells [24]. However, further studies are recommended to investigate this protective effect on chronic lung inflammation induced by long term exposure to oral ingestion of ZnO-NPs.…”

Section: Discussionmentioning

confidence: 99%

Anatomical and Histopathological Effects of Zinc Oxide Nanoparticles on Lungs in Adult Male Albino Rats

Nabil¹,

Achy²

2019

IJAR

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Background: Zinc oxide nanoparticles (ZnO-NPs) are frequently used in many fields, including food industry for their antimicrobial activity. Acute exposure to high doses of such particles was found to be toxic to many organs. However, the lung toxicity resulting from chronic exposure to oral doses of ZnO-NPs was not adequately assessed before.Aim of the work: to detect the anatomical and histopathological effects of chronic exposure to ingested ZnO-NPs on the lung of normal adult male albino rat.Material and methods: It was carried out on 30 adult male Swiss albino rats with an average weight of 150-200 gm. They were divided into two groups: Group I: 10 rats serving as control group; Group II: 20 rats serving as experimental groups, divided into 2 subgroups (a&b) receiving oral ingestion by orogastric tube of a single daily dose (125mg/ kg) of average 20 nm sized ZnO-NPs for different durations: Group IIa (n=10): for 120 days; Group IIb (n=10): for 180 days. Histopathology and immunohistochemistry of the lungs in the three groups was performed to detect the possible effect of such exposure.Results: Oral administration of ZnO-NPs induced lung damage manifested by congested blood vessels, interstitial inflammation, infiltration with macrophages& lymphocytes, supurative granuloma, thickened interalveolar septa. These changes were more evident with longer exposure for 180 days (P < 0.5). This substantial damage to the lungs is caused by oxidative stress and chronic inflammation. Conclusion:Caution should be considered when using these particles in food packaging and food additives, and for those who are in close contact with these particles especially in factories.

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“…In in vitro assays, in human lung carcinoma, A549 cells showed significant toxicity of ZnO-NPs. Exposure to vitamin C leads to a decrease in intracellular ROS production which lowered the inflammation level [91]. The proposed mechanism of vitamin C action was based on its antioxidant activity and chelating reaction with Zn leading to the formation of a stable complex.…”

Section: Antioxidantsmentioning

confidence: 99%

An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle‐Induced Toxicities

Mihailović

Stanković

Selaković

et al. 2021

Oxidative Medicine and Cellular Longevity

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Nanoparticles (NPs) are used in many products and materials for humans such as electronics, in medicine for drug delivery, as biosensors, in biotechnology, and in agriculture, as ingredients in cosmetics and food supplements. Besides that, NPs may display potentially hazardous properties on human health and the environment as a consequence of their abundant use in life nowadays. Hence, there is increased interest of researchers to provide possible therapeutic agents or dietary supplements for the amelioration of NP-induced toxicity. This review summarizes the new findings in the research of the use of antioxidants as supplements for the prevention and alleviation of harmful effects caused by exposure of organisms to NPs. Also, mechanisms involved in the formation of NP-induced oxidative stress and protective mechanisms using different antioxidant substances have also been elaborated. This review also highlights the potential of naturally occurring antioxidants for the enhancement of the antioxidant defense systems in the prevention and mitigation of organism damage caused by NP-induced oxidative stress. Based on the presented results of the most recent studies, it may be concluded that the role of antioxidants in the prevention and treatment of nanoparticle-induced toxicity is unimpeachable. This is particularly important in terms of oxidative stress suppression.

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Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

Cited by 16 publications

References 35 publications

Vitamin C promotes oligodendrocytes generation and remyelination

Vitamin C promotes oligodendrocytes generation and remyelination

Anatomical and Histopathological Effects of Zinc Oxide Nanoparticles on Lungs in Adult Male Albino Rats

An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle‐Induced Toxicities

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