Alteration of mercuric chloride-induced autoimmune glomerulonephritis in Brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor

Papanikolaou, Nikolaos

doi:10.1016/0262-1746(87)90066-7

Cited by 11 publications

(3 citation statements)

References 51 publications

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“…Since Prickett et aL (13) reported the beneficial effects of fish oil on experimental nephritis of NZB X NZW F1 mice, several papers have appeared reporting effects of fish oil on experimental nephritis and renal insufficiency (14)(15)(16)(17)(18)(19)(20)(21). Beneficial effects of fish oil on immtmoglobulin A (IgA) nephropathy (22) and hemodialysis patients (12) were also reported from our laboratory.…”

Section: Discussionmentioning

confidence: 72%

“…The reduction in albumin excretion levels in the EPA group was significant both in NIDDM and IDDM patients. Combined values were also significantly reduced from 65 (30,141) to 36 (15, 85) mg/g creatinine (p<0.001), while the excretion levels were unchanged in the Reference group (55 (21,145) to 54 (17, 174) mg/g creatinine, combined values). There were no significant changes in blood chemistry, including urea nitrogen, creatlnlne and lipid levels during the study in either of the groups (Table 3).…”

Section: Resultsmentioning

confidence: 87%

“…In the EPA group, tool% of EPA in plasma total fatty acids of each patient increased more than 25% above the baseline value, and did not change in the Reference group (Table 2). Combined values were also significantly reduced from 65 (30,141) to 36 (15, 85) mg/g creatinine (p<0.001), while the excretion levels were unchanged in the Reference group (55 (21,145) to 54 (17, 174) mg/g creatinine, combined values). There were no significant changes in systolic or diastolic blood pressure or in body weight in either of the groups ( Table 2).…”

Section: Resultsmentioning

confidence: 87%

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Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester

Hamazaki

Takazakura

Osawa

et al. 1990

Lipids

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Eicosapentaenoic acid (EPA) ethyl ester (1.8 g/d) was administered to 16 diabetic patients (5 insulin-dependent and 11 noninsulin-dependent diabetics) for 6 mon. EPA in total plasma fatty acids increased from 4.0 +/- 2.4 mol% (mean +/- SD) to 7.5 +/- 3.1 mol% (p less than 0.001). Albumin excretion, measured with spot urine, was significantly reduced from 65 to 36 mg/g creatinine (geometric means, p less than 0.001). Fasting blood sugar levels, glycohemogloblin, body weight and blood pressure did not change significantly during the study. There were also no significant changes in serum levels of creatinine, urea nitrogen, total cholesterol and triglycerides. Although no overt hemorrhage was observed in the patients, hematocrit was reduced from 42.6 +/- 2.8% to 41.0 +/- 3.9% (p less than 0.02). Ten other similar diabetic patients (4 insulin-dependent and 6 noninsulin-dependent diabetics) were followed as a reference group, not concomitantly, for 6 mon with neither EPA ethyl ester nor placebo. The parameters mentioned above were not changed significantly in this group during 6 mon. EPA administration might retard the appearance of overt diabetic nephropathy.

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Section: Discussionmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 87%

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Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester

Hamazaki

Takazakura

Osawa

et al. 1990

Lipids

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Effect of eicosapentaenoic acid ethyl ester on proteinuria of streptozotocin‐induced diabetes mellitus in rats

Fujikawa

Yamazaki

Sawazaki

et al. 1989

Lipids

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Streptozotocin (45 mg/kg) was intravenously administered to 7-week-old Wistar rats through their tail veins. After 11 days, the rats were divided into two groups. One group was fed a lipid-free diet (90%, w/w) plus lard (8%) and safflower oil (2%) for four weeks (Diet 1 group, n = 12). The other group was fed in the same way, except that safflower oil was replaced by 90% pure eicosapentaenoic acid (EPA) ethyl ester (Diet 2 group, n = 13). Twenty-four-hour urine was collected just before the diets started and during the experiment at 7-day intervals. In the second and third week, the levels of proteinuria were significantly lower in the Diet 2 group than they were in the Diet 1 group. There was no significant difference in the levels of creatinine, urea nitrogen, or lipids in plasma or in body weights between the two groups after four weeks on the diets. Because Diet 2 reduced proteinuria of diabetic rats compared to Diet 1, an EPA-rich diet may retard the development of diabetic nephropathy.

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The Significance of Fish and Fish-oil Enriched Food for Prevention and Therapy of Ischaemic Cardiovascular Disease

Hornstra¹

1989

Role of Fats in Human Nutrition

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Alteration of mercuric chloride-induced autoimmune glomerulonephritis in Brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor

Cited by 11 publications

References 51 publications

Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester

Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester

Effect of eicosapentaenoic acid ethyl ester on proteinuria of streptozotocin‐induced diabetes mellitus in rats

The Significance of Fish and Fish-oil Enriched Food for Prevention and Therapy of Ischaemic Cardiovascular Disease

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