Alteration of Swallowing and Ventilation Coordination in Respiratory Diseases in Small Mammals

Ghannouchi, I.; Marie, Jean‐Paul; Duclos, C.; Vérin, Eric

doi:10.1007/s00455-019-10024-x

Cited by 6 publications

(11 citation statements)

References 24 publications

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“…Several articles evaluated the possibility of dysphagia due to lack of coordination between swallowing and ventilation in the animal model of respiratory failure [ 43 , 44 ]. In both of the two retrieved articles, 250–300 g male rats were used.…”

Section: Resultsmentioning

confidence: 99%

“…It was claimed that this can explain the possibility of aspiration during respiratory failure [ 43 ]. In another article, the swallowing frequency was remarkably high in rats with pulmonary emphysema compared to the control group [ 44 ]. The frequency of swallowing during exhalation was decreased in rats with pulmonary emphysema and pulmonary fibrosis.…”

Section: Resultsmentioning

confidence: 99%

“…The frequency of swallowing during exhalation was decreased in rats with pulmonary emphysema and pulmonary fibrosis. This suggested that respiratory diseases are related to swallowing–ventilation coordination and may increase risks of aspiration [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…Aspiration may occur during respiratory failure from lack of coordination between swallowing and ventilation. Increased risk in aspiration was reported in rats with experimentally induced pulmonary emphysema and pulmonary fibrosis [ 43 , 44 ]. Additionally, probability of dysphagia was also identified in Rdh10 mutant mice with cleft palate due to retinoid deficiency, TPH2 knockout (TPH -/- ) mice with serotonin (5-hydroxytryptamine [5-HT]) deficiency, and Uch-L1 gad /Uch-L3 Δ 3–7 double homozygous mice used as a neuro-degenerative animal model [ 45 , 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

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A Systematic Review of Oropharyngeal Dysphagia Models in Rodents

Kim

2021

IJERPH

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Oropharyngeal dysphagia is a condition characterized by swallowing difficulty in the mouth and pharynx, which can be due to various factors. Animal models of oropharyngeal dysphagia are essential to confirm the cause-specific symptoms, pathological findings, and the effect of treatment. Recently, various animal models of dysphagia have been reported. The purpose of this review is to organize the rodent models of oropharyngeal dysphagia reported to date. The articles were obtained from Medline, Embase, and the Cochrane library, and selected following the PRISMA guideline. The animal models in which oropharyngeal dysphagia was induced in rats or mice were selected and classified based on the diseases causing oropharyngeal dysphagia. The animal used, method of inducing dysphagia, and screening methods and results were collected from the selected 37 articles. Various rodent models of oropharyngeal dysphagia provide distinctive information on atypical swallowing. Applying and analyzing the treatment in rodent models of dysphagia induced from various causes is an essential process to develop symptom-specific treatments. Therefore, the results of this study provide fundamental and important data for selecting appropriate animal models to study dysphagia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Systematic Review of Oropharyngeal Dysphagia Models in Rodents

Kim

2021

IJERPH

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“…Using whole-body plethysmography and video recordings of (i) normal rat models, (ii) rats suffering from pulmonary emphysema, the authors discovered that there was significant difference in the stated coordination in group (ii). They inferred that respiratory diseases are associated with changes in swallowing-ventilation coordination [52]. Symptoms of similar dis-coordination might be an indication of aspiration/lung diseases.…”

Section: Swallowing Stops Respiratory Action For a Short Period-more mentioning

confidence: 99%

A Novel Apprehension of the Primary Lung Meridian, Sinew Channel, Divergent Channel, Luo-Connecting Channel Acting as a Single Unit System to Serve Respiration Function Based on Modern Neurophysiology and Kinesiology

Fung¹,

Kong²

2020

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The TCM philosophy of a meridian and associated channels pertains to the specific function of one or more organs. We define the Lung Primary Meridian (LUM) together with the Lung Sinew (LUSC), Divergent (LUDC), Luo-connecting (LULCC) Channels as a system of routes plus some parts of the body (such as muscles) to fulfil respiration, as a main function under different situations. There is very limited information about the Lung associated channels in classical literature of TCM. With a clear focus on the function of respiration, we have carried out a detailed analysis of the biomedical consequence of stimulating the LUM, analysed the roles played by LUSC, LUDC, and LULCC. The updated LUM and LUDC include acupoints of other meridians, serving the same purpose of performing satisfactory respiration starting from checking the quality of the inflow through the nose. The LUSC includes the respiratory muscles (plus the associated connective tissues) extending to various parts of the body. The muscles of the limb (as part of the LUSC) embrace the nerves that provide routes for somatosensory reflexes and play the role of locomotion, providing voluntary respiration via the pectoralis muscles. The muscles of LUSC are bounded by stiff connective tissue layers, forming compartments, and are part of the pulley system for various body locomotions. Within a compartment, the interstitial fluid, blood, lymph flows must be potent to protect the associated nerves related to LUM; the healthy state of the LUSC also provides freedom of various types of locomotion. The LULCC exists because the vagus nerve has a part of it passing through the spinal cords all the way down to the sacrum domain, with

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Respiratory‐swallow coordination in a rat model of chemoradiation

2021

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Background Chemoradiation treatment (CRT) for head and neck cancer (HNC) is associated with postswallow inhale events that elevate the risk of penetration/aspiration. The purpose of this study was to assess the validity of a rat model for investigating the effect of CRT on respiratory‐swallow coordination. Methods Videofluoroscopic swallow study was performed on 10 Sprague‐Dawley rats 3 months post‐CRT (3 mg/kg Cisplatin, 10 fractions of 4.5 Gy/day radiotherapy to tongue base), and 10 naïve controls. We examined the effect of CRT on swallow apnea duration, diaphragm movement, and bolus kinematics. Results CRT rats had a significant increase in postswallow inhale (p = 0.008), which was associated with significantly longer swallow apnea durations, lower diaphragm displacement at swallow onset, and faster pharyngoesophageal bolus speed. Conclusion The rat CRT model is valid for the study of respiratory‐swallow coordination due to the consistency of findings in this study with those reported in clinical CRT studies in HNC.

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Alteration of Swallowing and Ventilation Coordination in Respiratory Diseases in Small Mammals

Cited by 6 publications

References 24 publications

A Systematic Review of Oropharyngeal Dysphagia Models in Rodents

A Systematic Review of Oropharyngeal Dysphagia Models in Rodents

A Novel Apprehension of the Primary Lung Meridian, Sinew Channel, Divergent Channel, Luo-Connecting Channel Acting as a Single Unit System to Serve Respiration Function Based on Modern Neurophysiology and Kinesiology

Respiratory‐swallow coordination in a rat model of chemoradiation

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