Alteration of the ERK5 pathway by hydroxysafflor yellow A blocks expression of MEF2C in activated hepatic stellate cells<i>in vitro</i>: Potential treatment for hepatic fibrogenesis

Dong, Huijuan; Liu, Yuzhang; Zou, Yu; Li, Chengchong; Li, Libo; Li, Xiaoming; Zhao, Xuemei; Zhou, Li; Liu, Jicheng; Niu, Yingcai

doi:10.3109/13880209.2013.840850

Cited by 9 publications

(4 citation statements)

References 38 publications

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“…It was reported that the aqueous extract of safflower reduced liver fibrosis and renal interstitial fibrosis by suppressing TGF-β1expression. 16) While, the effect of HSYA on the fibrosis of ARDS has not been reported up to now, our results indicate the protective effect of HSYA on early fibrosis of ARDS. Augmented expression of TGF-β1, α-SMA, Col I and Col III was decreased after the treatment of HSYA, especially at the 56 mg/kg dose.…”

Section: Discussionsupporting

confidence: 53%

Hydroxysafflor Yellow A Alleviates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Mice

Zhang

Song

Pan

et al. 2017

Biological & Pharmaceutical Bulletin

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Section: Discussionsupporting

confidence: 53%

Hydroxysafflor Yellow A Alleviates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Mice

Zhang

Song

Pan

et al. 2017

Biological & Pharmaceutical Bulletin

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“…In another study, SY improved cognitive function and astrocytes in an AD mouse model, the results showing that SY holds promise as a therapeutic approach for the treatment of AD [96]. The injection of 30 µm HSYA in rat hepatic stellate cells (HSCs) showed inhibition of HSC activation and cell proliferation, indicating it is a potential candidate for the prevention and treatment of hepatic fibrogenesis [97]. The effects of HSYA on lymphostatic encephalopathy (LE) induced brain changes in rats, supporting HSYA for the treatment of lymphostatic encephalopathy [98].…”

Section: Brain and Liver Disease Effectsmentioning

confidence: 99%

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

et al. 2020

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Safflower (Carthamus tinctorius L.) has long been grown as a crop due to its commercial utility as oil, animal feed, and pharmacologically significant secondary metabolites. The integration of omics approaches, including genomics, transcriptomics, metabolomics, and proteomics datasets, has provided more comprehensive knowledge of the chemical composition of crop plants for multiple applications. Knowledge of a metabolome of plant is crucial to optimize the evolution of crop traits, improve crop yields and quality, and ensure nutritional and health factors that provide the opportunity to produce functional food or feedstuffs. Safflower contains numerous chemical components that possess many pharmacological activities including central nervous, cardiac, vascular, anticoagulant, reproductive, gastrointestinal, antioxidant, hypolipidemic, and metabolic activities, providing many other human health benefits. In addition to classical metabolite studies, this review focuses on several metabolite-based working techniques and updates to provide a summary of the current medical applications of safflower.

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“…Some of the DE mRNAs were shown to participate in the process of liver cirrhosis. In addition to FOXP3 mentioned above, CXCL11 has been reported to be significantly associated with liver cirrhosis following viral hepatitis, and overexpression of MEF2C can activate HSCs[28, 29]. These immune-related mRNAs, which are linked with liver cirrhosis, are target genes of miR-219-5p.…”

Section: Discussionmentioning

confidence: 99%

Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis

et al. 2017

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Liver cirrhosis is recognized as being the consequence of immune-mediated hepatocyte damage and repair processes. However, the regulation of these immune responses underlying liver cirrhosis has not been elucidated. In this study, we used GEO datasets and bioinformatics methods to established coding and non-coding gene regulatory networks including transcription factor-/lncRNA-microRNA-mRNA, and competing endogenous RNA interaction networks. Our results identified 2224 mRNAs, 70 lncRNAs and 46 microRNAs were differentially expressed in liver cirrhosis. The transcription factor -/lncRNA- microRNA-mRNA network we uncovered that results in immune-mediated liver cirrhosis is comprised of 5 core microRNAs (e.g., miR-203; miR-219-5p), 3 transcription factors (i.e., FOXP3, ETS1 and FOS) and 7 lncRNAs (e.g., ENTS00000671336, ENST00000575137). The competing endogenous RNA interaction network we identified includes a complex immune response regulatory subnetwork that controls the entire liver cirrhosis network. Additionally, we found 10 overlapping GO terms shared by both liver cirrhosis and hepatocellular carcinoma including “immune response” as well. Interestingly, the overlapping differentially expressed genes in liver cirrhosis and hepatocellular carcinoma were enriched in immune response-related functional terms. In summary, a complex gene regulatory network underlying immune response processes may play an important role in the development and progression of liver cirrhosis, and its development into hepatocellular carcinoma.

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Alteration of the ERK5 pathway by hydroxysafflor yellow A blocks expression of MEF2C in activated hepatic stellate cellsin vitro: Potential treatment for hepatic fibrogenesis

Cited by 9 publications

References 38 publications

Hydroxysafflor Yellow A Alleviates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Mice

Hydroxysafflor Yellow A Alleviates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Mice

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis

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