Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis

Gao, Bo; Zhang, Xueming; Huang, Yingqi; Yang, Zhengpeng; Zhang, Yuguo; Zhang, Weihui; Gao, Zu–Hua; Xue, Dongbo

doi:10.1371/journal.pone.0174142

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…Interestingly, this competing mechanism also affects immune responses, such as in liver cirrhosis [ 164 ] or in early HIV infection (EHI) gene expression regulatory networks [ 165 ] and it participates in the regulation and evolution of deceitful autoimmune diseases like rheumatoid arthritis [ 166 , 167 ].…”

Section: Cerna and Diseasesmentioning

confidence: 99%

Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story

Ala

2020

Cells

130

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MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and non-coding RNA molecules can be targeted by the same miRNAs and can indirectly regulate each other by competing for them. These RNAs, otherwise known as competing endogenous RNAs (ceRNAs), lead to an additional post-transcriptional regulatory layer, where non-coding RNAs can find new significance. The miRNA-mediated interplay among different types of RNA molecules has been observed in many different contexts. The analyses of ceRNA networks in cancer and other pathologies, as well as in other physiological conditions, provide new opportunities for interpreting omics data for the field of personalized medicine. The development of novel computational tools, providing putative predictions of ceRNA interactions, is a rapidly growing field of interest. In this review, I discuss and present the current knowledge of the ceRNA mechanism and its implications in a broad spectrum of different pathologies, such as cardiovascular or autoimmune diseases, cancers and neurodegenerative disorders.

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Section: Cerna and Diseasesmentioning

confidence: 99%

Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story

Ala

2020

Cells

130

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“…Other causes include primary biliary cirrhosis (PBC), autoimmune hepatitis, primary sclerosing cholangitis, and genetic and metabolic diseases, such as Wilson's disease and hemochromatosis. A complex gene regulatory network underlying immune response processes might play an important role in the development and progression of liver cirrhosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A Meta-Analysis of the Influence of Tumor Necrosis Factor-α-308 Gene Polymorphism on Liver Cirrhosis

Liu

Yang

2022

Journal of Healthcare Engineering

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Cirrhosis is an active hepatic inflammation process of the liver considered as the serious phase of different liver injuries. Epidemiological studies have evaluated the possible association between TNF-α-308G/A gene polymorphism and liver cirrhosis. In this study, we have furthered the study to assess the exact association of TNF-α-308G/A gene polymorphism with liver cirrhosis susceptibility by integrating all available data. Eligible case-control studies were carried out from the establishment of the project to September 2021. Published literature from multiple databases was retrieved, collected, and analyzed by two investigators independently. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for every study. Review Manager 5.2 and Stata 15.0 software were used for meta-analysis and stability was assessed by both subgroup analysis and sensitivity analysis. Begg’s funnel plot and Egger’s regression across the studies were also explored. We examined 22 case-control studies with 2683 cirrhosis patients and 2905 normal controls in four genetic models (GA vs. GG: OR = 0.95, 95%CI: (0.70, 1.30); AA vs. GG: OR = 1.11, 95% CI: (0.66, 1.85), GA + AA vs. GG: OR = 1.00, 95% CI: (0.73, 1.37); AA vs. GA + GG: OR = 1.07, 95%CI: (0.70,1.63)). TNF-α-308G/A gene polymorphism was relatively independent, and the results did not show a significant difference between the two groups. In the subgroup analysis by etiological classification of liver cirrhosis, cirrhosis after HCV infection was positively associated with the risk of TNF-α-308G/A polymorphism (AA vs. GG: OR = 3.02, 95% CI: (1.15, 7.88), AA vs. GA + GG: OR = 2.68, 95% CI: (1.04, 6.95)). The meta-analysis showed TNF-α-308G/A gene polymorphism might not have affected susceptibility for liver cirrhosis. Nevertheless, further and well-designed studies were needed to confirm the findings.

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“…Chen et al 33 found that miR-219-5p prevented cirrhosis through increasing keratinocyte growth factor (KGF). The study by Gao et al 34 indicated that miR-219-5p was differentially expressed in liver cirrhosis, suggesting that miR-219-5p might affect the process of liver cirrhosis. The above evidence indicated the important role of miR-219-5p in liver injury.…”

Section: Discussionmentioning

confidence: 99%

Aberrant miR-219-5p is correlated with TLR4 and serves as a novel biomarker in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning

Dai

Liu

Guo

2020

Int J Immunopathol Pharmacol

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This study aimed to investigate the clinical significance of serum microRNA-219-5p (miR-219-5p) in patients with multiple organ dysfunction syndrome (MODS) caused by acute paraquat (PQ) poisoning, and its correlation with Toll-like Receptor 4 (TLR4). Luciferase reporter assay was used to investigate in vitro the correlation of miR-219-5p with TLR4. Serum miR-219-5p levels were evaluated by quantitative real-time polymerase chain reaction. Serum levels of TLR4, IL-1β, and TNF-α were measured by Enzyme-linked immune sorbent assay (ELISA). ROC analysis was performed to assess the diagnostic significance, Kaplan-Meier survival curves and Cox regression analysis were used to evaluate the prognostic value of miR-219-5p in MODS patients. TLR4 was a target gene of miR-219-5p and was increased in MODS patients. Serum miR-219-5p level was decreased and negatively correlated with TLR4 level in MODS patients ( r = −0.660, P < 0.001), which had important diagnostic value and negatively correlated with APACHE II score in MODS patients. The miR-219-5p expression was markedly associated with the WBC, ALT, AST, PaCO2, Lac, and APACHE II score. Non-survivals had more patients with low miR-219-5p expression. Patients with low miR-219-5p expression had shorter survival time. MiR-219-5p and APACHE II score were two independently prognostic factors for 28-day survival. MiR-219-5p was negatively correlated with, while TLR4 was positively correlated with the levels of IL-1β and TNF-α. The serum miR-219-5p level may be a potential biomarker for acute PQ-induced MODS diagnosis and prognosis. Furthermore, miR-219-5p may be associated with the progression of MODS by regulating TLR4-related inflammatory response.

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Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis

Cited by 7 publications

References 41 publications

Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story

Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story

A Meta-Analysis of the Influence of Tumor Necrosis Factor-α-308 Gene Polymorphism on Liver Cirrhosis

Aberrant miR-219-5p is correlated with TLR4 and serves as a novel biomarker in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning

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