Alteration of the soluble guanylate cyclase system in coronary arteries of high cholesterol diet‐fed rabbits

Tawa, Masashi; Nakano, Kenji; Yamashita, Yuka; He, Qiang; Masuoka, Takayoshi; Okamura, Tomio; Ishibashi, Takaharu

doi:10.1002/prp2.838

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…Therefore, hypertension alone does not seem to be accompanied by a shift in the sGC redox balance toward the NO-insensitive state. On the other hand, the imbalance between NO-sensitive and NO-insensitive sGC has been confirmed in blood vessels with neointimal thickening and atherosclerotic plaque [20, 23‒25]. This might suggest that only severely diseased blood vessels carry a risk for disrupting the balance in sGC.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Soluble Guanylate Cyclase-Mediated Relaxation in Aortas from Rats with Renovascular Hypertension

et al. 2021

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Soluble guanylate cyclase (sGC) plays an important role in nitric oxide (NO)-mediated regulation of vascular tone; however, NO bioavailability is often reduced in diseased blood vessels. Accumulating evidence suggests that a shift of sGC from the NO-sensitive form to the NO-insensitive form could be an underlying cause contributing to this reduction. Herein, we investigated the impact of renovascular hypertension on NO-sensitive and NO-insensitive sGC-mediated relaxation in rat aortas. Renovascular hypertension was induced by partially clipping the left renal artery (2-kidneys, 1-clip; 2K1C) for 10 weeks. Systolic, diastolic, and mean arterial pressures were significantly increased in the 2K1C group when compared with the sham group. In addition, plasma thiobarbituric acid reactive substances and aortic superoxide generation were significantly enhanced in the 2K1C group when compared with those in the sham group. The vasorelaxant response of isolated aortas to the sGC stimulator BAY 41-2272 (NO-sensitive sGC agonist) was comparable between the sham and 2K1C groups. Likewise, the sGC activator BAY 60-2770 (NO-insensitive sGC agonist)-induced relaxation did not differ between the sham and 2K1C groups. In addition, the cGMP mimetic 8-Br-cGMP (protein kinase G agonist) induced similar relaxation in both groups. Furthermore, there were no differences in BAY 41-2272-stimulated and BAY 60-2770-stimulated cGMP generation between the groups. These findings suggest that the balance between NO-sensitive and NO-insensitive forms of sGC is maintained during renovascular hypertension. Therefore, sGC might not be responsible for the reduced NO bioavailability observed during renovascular hypertension.

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Section: Discussion/conclusionmentioning

confidence: 99%

Soluble Guanylate Cyclase-Mediated Relaxation in Aortas from Rats with Renovascular Hypertension

et al. 2021

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Different sensitivities of porcine coronary arteries and veins to BAY 60–2770, a soluble guanylate cyclase activator

Tawa,

Nakagawa,

Ohkita

2025

Journal of Pharmacological Sciences

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Factors influencing the soluble guanylate cyclase heme redox state in blood vessels

Tawa

Okamura

2022

Vascular Pharmacology

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Alteration of the soluble guanylate cyclase system in coronary arteries of high cholesterol diet‐fed rabbits

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 5 publications

References 54 publications

Soluble Guanylate Cyclase-Mediated Relaxation in Aortas from Rats with Renovascular Hypertension

Soluble Guanylate Cyclase-Mediated Relaxation in Aortas from Rats with Renovascular Hypertension

Different sensitivities of porcine coronary arteries and veins to BAY 60–2770, a soluble guanylate cyclase activator

Factors influencing the soluble guanylate cyclase heme redox state in blood vessels

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