Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study

Li, Xiao; Yu, Renqiang; Huang, Qian; Chen, Xiaolu; Ai, Ming; Zhou, Yi; Dai, Linqi; Qin, Xiaoyue; Kuang, Li

doi:10.3389/fnhum.2021.762343

Cited by 27 publications

(20 citation statements)

References 61 publications

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“…Mao et al reported an elevated ReHo value in the right precentral gyrus in adolescent MDD relative to HCs (14), which is in line with our results. Further, fALFF in the right precentral gyrus in depressed adolescents with suicidal ideation was found to be significantly decreased after electroconvulsive therapy (17), and higher FC between the right precentral gyrus and left habenula was also noted in individuals with MDD or bipolar disorder and a history of SA relative to patients without SA (45). Taken together with the above studies, our findings suggest that the right precentral gyrus may be involved in the neural circuitry of suicide in MDD.…”

Section: Discussionmentioning

confidence: 99%

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Liu

Huang

et al. 2022

Front. Psychiatry

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BackgroundThe neurobiological basis of suicidal behaviors among female adolescents with major depressive disorder (MDD) remains largely unclear.Materials and methodsFifty-eight drug-naïve, first-episode female adolescent MDD [including 31 patients with suicidal attempt (SA group) and 27 patients without SA (non-SA group)], and 36 matched healthy controls (HCs) participated in the present study. Resting-state functional magnetic resonance imaging (MRI) was performed on each subject. The metrics of the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared among the three groups. Then seed-based functional connectivity (FC) was conducted based on the ALFF/fALFF and ReHo results, which were then correlated to clinical variables.ResultsCompared with the non-SA group, the SA group exhibited increased fALFF in the bilateral insula and right precentral gyrus, and enhanced ReHo in the left superior temporal gyrus, left middle cingulate cortex, right insula, and right precentral gyrus. Relative to the HCs, the SA group demonstrated additionally reduced fALFF and ReHo in the left middle frontal gyrus. Moreover, the SA group showed increased FC between the right precentral gyrus and the left middle frontal gyrus and left insula, and between the right insula and anterior/middle cingulate cortex compared to the non-SA and HC groups. In addition, the fALFF in the left middle frontal gyrus was positively correlated with the 17-item Hamilton Depression Rating Scale scores, and the values in the fALFF/ReHo in the right insula were positively correlated with the duration of MDD within the patient group.ConclusionThese findings highlight the multiple abnormalities of the frontolimbic circuit, which may enhance our understanding of the neurobiological basis underlying female MDD with SA during adolescence.

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Section: Discussionmentioning

confidence: 99%

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Liu

Huang

et al. 2022

Front. Psychiatry

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“…It is worth noting that long-distance connections and local brain neural activities often occur simultaneously and interact (47,48). In addition, previous studies have documented that depression symptoms are negatively correlated with local neural activity in the brain (49,50). Therefore, the inter-modular connections between the FPN and CON that decrease with the increase in depressive symptoms may reflect the decrease in local neural activity in the brain, rather than long-distance abnormal changes.…”

Section: Discussionmentioning

confidence: 94%

Decreased modular segregation of the frontal–parietal network in major depressive disorder

et al. 2022

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Major depressive disorder (MDD) is a common psychiatric condition associated with aberrant large-scale distributed brain networks. However, it is unclear how the network dysfunction in MDD patients is characterized by imbalance or derangement of network modular segregation. Fifty-one MDD patients and forty-three matched healthy controls (HC) were recruited in the present study. We analyzed intrinsic brain activity derived from resting-state functional magnetic resonance imaging (R-fMRI) and then examined brain network segregation by computing the participation coefficient (PC). Further intra- and inter-modular connections analysis were preformed to explain atypical PC. Besides, we explored the potential relationship between the above graph theory measures and symptom severity in MDD. Lower modular segregation of the frontal–parietal network (FPN) was found in MDD compared with the HC group. The MDD group exhibited increased inter-module connections between the FPN and cingulo-opercular network (CON), between the FPN and cerebellum (Cere), between the CON and Cere. At the nodal level, the PC of the anterior prefrontal cortex, anterior cingulate cortex, inferior parietal lobule (IPL), and intraparietal sulcus showed larger in MDD. Additionally, the inter-module connections between the FPN and CON and the PC values of the IPL were negatively correlated with depression symptom in the MDD group. These findings might give evidence about abnormal FPN in MDD from the perspective of modular segregation in brain networks.

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“…The latest findings of structural MRI can use the volume and thickness of cortical gray matter, subcortical volume, and the integrity of white matter bundle to examine the brain structure (or anatomical) changes in neural circuits (10). In the related study of major depressive disorder, it is found that ECT has a certain effect (1). After ECT, amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) of the right precentral gyrus decreased significantly, and there was a significant correlation between the changes of depressive symptom and ALFF, and between suicidal ideation and fALFF.…”

Section: Major Depressive Disordermentioning

confidence: 99%

Commentary: Targeting the MRI-mapped psychopathology of major psychiatric disorders with neurostimulation

Xie

Cui²,

Cao³

et al. 2022

Front. Psychiatry

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Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study

Cited by 27 publications

References 61 publications

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Decreased modular segregation of the frontal–parietal network in major depressive disorder

Commentary: Targeting the MRI-mapped psychopathology of major psychiatric disorders with neurostimulation

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