Alterations in Blood-Aqueous Barrier After Corneal Refractive Surgery

Vita, Ruth Cardoso; Campos, Mauro; Belfort, Rubens; Paiva, Elias Rodrigues de

doi:10.1097/00003226-199803000-00007

Cited by 20 publications

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“…Our findings in eyes subjected to corneo-limbal cut and perforation (paracentesis) are in agreement with well-established data on paracentesis-induced BAB failure in primates [3,24] and with other experimental models in which inflammation was induced by intraocular injection of leukotriene B4 (LTB4) [37], combined injection of TNF-αand IL-6 [9,13], or TNF alone [10,16].…”

Section: Discussionsupporting

confidence: 90%

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Melanocortins are comparable to corticosteroids as inhibitors of traumatic ocular inflammation in rabbits

Naveh¹,

Marshall

2001

Graefe's Arch Clin Exp Ophthalmol

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We demonstrated that MSH reduced the clinical signs of ocular inflammation, curtailed blood-aqueous barrier (BAB) disruption, and reduced aqueous inflammatory cell number. The efficacy of MSH applied systemically or topically was similar to that of steroids in reducing clinical signs of trauma, but MSH efficacy in maintaining BAB integrity surpassed that of steroids. We suggest that the melanocortins might be a useful anti-inflammatory agents in ocular trauma.

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Section: Discussionsupporting

confidence: 90%

“…Steroids are known to reduce aqueous protein levels in traumatized eyes: protein levels were diminished by steroids treatment following perforating corneal injury [37], or cataract surgery [27].…”

Section: Discussionmentioning

confidence: 99%

Melanocortins are comparable to corticosteroids as inhibitors of traumatic ocular inflammation in rabbits

Naveh¹,

Marshall

2001

Graefe's Arch Clin Exp Ophthalmol

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“…The case of recurrent iridocyclitis in our series might have been triggered by PRK, which is known to increase aqueous flare level (23,24). However, subclinical inflammation is a common finding after the implantation of angle-supported phakic IOLs (25), and a 1% incidence of chronic iridocyclitis has been reported after this surgery (26).…”

Section: Discussionmentioning

confidence: 71%

Bioptics by Angle-Supported Phakic Lenses and Photorefractive Keratectomy

Leccisotti¹

2005

European Journal of Ophthalmology

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“…It was suggested that the blood ocular barrier is altered following excimer laser procedures and particularly after PRK. For example, increased amounts of flare were measured in the anterior chamber 15 days after PRK [14]. This may facilitate drug penetration into the anterior chamber as well.…”

Section: Discussionmentioning

confidence: 99%

Does Photorefractive Keratectomy Alter the Effect of Topical Medications?

Nemet

Morad

2002

Ophthalmologica

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Introduction: The influence of photorefractive keratectomy (PRK) on drug penetration into the eye is not yet established, as this procedure may alter the barrier function of the cornea as well as the blood ocular barrier. Pupillary response to topical tropicamide depends on its penetration into the anterior chamber. The purpose of this study was to examine the influence of PRK on pupillary response to topical tropicamide, and hence to evaluate whether PRK alters drug penetration into the eye. Methods: Pupillary diameter was measured using infrared pupillometer at 0, 15 and 30 min after instillation of 0.1% tropicamide to both eyes of 28 patients 4 weeks after PRK in one eye. The untreated eye served as control. Results: Pupillary diameter before and 30 min after dilation was 7.4 ± 1.2 and 8.0 ± 1.0 mm in the treated eyes and 7.5 ± 1.2 and 8.1 ± 1.0 mm in the untreated eyes, respectively (p = 0.45). Percentage of pupillary dilation (Δ pupillary diameter/pupillary diameter at 0 min ×100) was also similar in treated and untreated eyes for the entire study group (12.5 and 10.5%, respectively, p = 0.17). A trend for greater dilation was seen in patients with myopia above 6 diopters (13.7 and 10.5% in treated and untreated eyes, respectively, p = 0.11) and cornea thinner than 540 µm (14.2 and 10.1% in treated and untreated eyes, respectively, p = 0.1). Discussion: Our results confirm animal and human studies that found restoration of the ocular drug barrier at 4 weeks following PRK. The trend for greater penetration in patients with high myopia and thin corneas warrants further study on a larger cohort of this subgroup.

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Alterations in Blood-Aqueous Barrier After Corneal Refractive Surgery

Cited by 20 publications

References 0 publications

Melanocortins are comparable to corticosteroids as inhibitors of traumatic ocular inflammation in rabbits

Melanocortins are comparable to corticosteroids as inhibitors of traumatic ocular inflammation in rabbits

Bioptics by Angle-Supported Phakic Lenses and Photorefractive Keratectomy

Does Photorefractive Keratectomy Alter the Effect of Topical Medications?

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