Melanocortins are comparable to corticosteroids as inhibitors of traumatic ocular inflammation in rabbits

Abstract

We demonstrated that MSH reduced the clinical signs of ocular inflammation, curtailed blood-aqueous barrier (BAB) disruption, and reduced aqueous inflammatory cell number. The efficacy of MSH applied systemically or topically was similar to that of steroids in reducing clinical signs of trauma, but MSH efficacy in maintaining BAB integrity surpassed that of steroids. We suggest that the melanocortins might be a useful anti-inflammatory agents in ocular trauma.

Inhibition of Endotoxin-Induced Uveitis and Potentiation of Cyclooxygenase-2 Protein Expression by α-Melanocyte–Stimulating Hormone

“…2 Furthermore, ␣-MSH has a potent anti-inflammatory action in brain inflammation, 3 renal injury, 4 and liver inflammation experimental models. 5 Other reports 6,7 of studies that have used the rabbit eye inflammation model, have found that ␣-MSH reduces blood-aqueous barrier failure and infiltration of inflammatory cells into the aqueous humor. One of the anti-inflammatory activities of MSH is reported to be the suppression of NF-B activation.…”

Adrenocorticotropic hormone gel for patients with non-infectious uveitis

“…Examples of such effects are suppression of pro-inflammatory cytokines production (interferon-γ, tissue necrosis factor-α, IL-1, and IL-8), induction of cytokine suppressors (IL-10), inhibition of expression of intercellular adhesion molecules and modulation of lymphocytes activity and proliferation 24 . The anti-inflammatory effects of α-MSH have been demonstrated in a variety of animal models, such as mice, rabbits, and rats 27, 28, 29…”

The Effects of Some Antibiotics on Sheep Lens Glucose 6-Phosphate Dehydrogenase in Vitro

“…The effects can be dramatic and systemic 33 . For example, Naveh and Marshall investigated the anti-inflammatory effect of melanocyte-stimulating hormone (MSH), which is a known anti-inflammatory agent, after ocular surgery 34 . Additionally, halothane was found to inhibit red blood cell and liver G6PD enzyme activities significantly in the first week and to activate this enzyme in the second week of anesthesia compared with a control group 35 .…”