Alterations in brain amino acid metabolism and inhibitory effects on PKC are possibly correlated with anticonvulsant effects of the isomeric mixture ofα- andβ-amyrin fromProtium heptaphyllum

Aragão, Gislei Frota; Carneiro, Lyvia Maria Vasconcelos; rota-Junior, Antônio Paulino; Bandeira, Paulo Nogueira; Lemos, Telma L. G.; Viana, Glauce Socorro de Barros

doi:10.3109/13880209.2014.923001

Cited by 15 publications

(6 citation statements)

References 28 publications

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“…The natural pentacyclic triterpenoid, ursolic acid, has been known to possess potent anti-inflammatory, antioxidant, and antinociceptive effects in various animal models [19]. In several studies, AMY has also demonstrated a great pharmacological applicability in several diseases [17][18][19][20][21] that have a common feature in their development: inflammation as one of the main mechanisms involved in their genesis [22,23]. AMY demonstrated peripheral and central analgesic effects independent of the opioid system and also showed a potent anti-inflammatory activity.…”

Section: A N T I -I N F L a M M A T O R Y A N D A N A L G E S I C A Cmentioning

confidence: 99%

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Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review

Nogueira

Oliveira

Adjafre³

et al. 2018

Fundamemntal Clinical Pharma

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Protium heptaphyllum Aubl. belongs to the Burseraceae family. It is commonly called 'almecegueira' and is known to produce an amorphous resin which has constituents such as α- and β-amyrin, taraxastan-3-oxo-20-ol and sitostenonein. The α- and β-amyrin from P. heptaphyllum have pharmacological activities in several systems, such as central and peripheral nervous system, gastrointestinal tract and immunological system. In this study, our objective was to review pharmacological activities and to gather more information on the mixture of α- and β-amyrin obtained from P. heptaphyllum to guide future preclinical and clinical studies using this compound. This review consisted of searches performed using scientific databases such as PubMed, SciELO, LILACS, SciFinder and Science Direct. Some uses of α- and β-amyrin have been partially confirmed by previous studies demonstrating analgesic, anti-inflammatory, anticonvulsant, antidepressive, gastroprotective, hepatoprotective, antipancreatitic, anticholytic, antihyperglycemic and hypolipidemic effects. It is noteworthy that there are no α- and β-amirin toxicity tests described in the literature as recommended in the international guidelines, and such tests are one of the research stages to proceed in clinical and preclinical trials if this compound was to be used.

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Section: A N T I -I N F L a M M A T O R Y A N D A N A L G E S I C A Cmentioning

confidence: 99%

“…The doses used were 10, 25 and 50 mg/kg. The changes in the balance between excitatory and inhibitory amino acids may be a factor by which the administration of AMY contributes to neuroprotection .…”

Section: Amyrin (αβ) Effects On Central Nervous Systemmentioning

confidence: 99%

Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review

Nogueira

Oliveira

Adjafre³

et al. 2018

Fundamemntal Clinical Pharma

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“…More specifically, α-and β-amyrins (AMY) are bioactive compounds that have been identified as anti-inflammatory and anti-oxidant agent agents by multiple sources and thus used for the treatment of diverse inflammation-related diseases . The chemical formula of α-amyrin(3α-hydroxy-urs-12-en-3-ol) is C 30 H 50 O (Figure 2), and its melting point is 184-186°C [103]; the chemical formula of β-amyrin(3β-hydroxy-olean-12-en-3-ol) is C 30 H 50 O (Figure 2) [106][107][108][109][110][111][112] and its melting point is 189-191°C [84]. Quintão et al (2014) demonstrated that AMY interferes in both acute and chronic inflammatory processes in mice by reducing mechanical hypersensitivity, mechanical sensitization, and oedema development in arthritis [86].…”

Section: Tomato Triterpenoidsmentioning

confidence: 99%

Biologically Active Triterpenoids and Their Cardioprotective and Anti- Inflammatory Effects

Bakovic¹

2015

J Bioanal Biomed

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“…The resin, popularly known as "almécega" or "breu branco", is collected and used locally in folk medicine practices for its analgesic, anti-inflammatory, and expectorant effects; some recent works have demonstrated several of those activities. In particular, concerning central actions, Aragão and colleagues showed in a murine model system both anticonvulsant effects related to the GABAergic system [28,29], and anxiolytic and antidepressant effects involving benzodiazepine-type receptors and noradrenergic mechanisms [26]. In addition, antinociceptive potential was also demonstrated [30,31].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential

Mannino

Iovino²,

Lauria

et al. 2021

IJMS

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Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and GC-FID/MS identified 13 compounds mainly belonging to ursane, oleanane, and tirucallane groups. Studies on human hepatocytes have revealed how PHE is able to reduce cholesterol production and regulate the expression of proteins involved in its metabolism. (HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR). Moreover, measuring the inhibitory activity of PHE against HMGR, moderate inhibition was recorded. Finally, molecular docking studies identified acidic tetra- and pentacyclic triterpenoids as the main compounds responsible for this action. In conclusion, our study demonstrates how PHE may be a useful alternative to contrast hypercholesterolemia, highlighting its potential as a sustainable multitarget natural extract for the nutraceutical industry that is rapidly gaining acceptance as a source of health-promoting compounds.

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Alterations in brain amino acid metabolism and inhibitory effects on PKC are possibly correlated with anticonvulsant effects of the isomeric mixture ofα- andβ-amyrin fromProtium heptaphyllum

Cited by 15 publications

References 28 publications

Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review

Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review

Biologically Active Triterpenoids and Their Cardioprotective and Anti- Inflammatory Effects

Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential

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