Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period

Guzman, Rose M. De; Rosinger, Zachary J.; Parra, Katherine; Jacobskind, Jason S.; Justice, Nicholas J.; Zuloaga, Damian G.

doi:10.1016/j.yhbeh.2021.105044

Cited by 9 publications

(19 citation statements)

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“…Recent studies from our laboratory demonstrated dynamic changes in CRFR1 levels in mice during the mid-lactation period (postpartum day 14, P14) that may contribute to stress-related behavioral changes in maternal mice. Specifically, we found changes within three brain regions associated with stress regulation and maternal care: the rostral anteroventral periventricular nucleus (AVPV/PeN), paraventricular hypothalamus (PVN), and medial preoptic area (MPOA) [26]. We also observed changes in CRFR1 co-localization with tyrosine hydroxylase (TH) within select brain regions, particularly the AVPV/PeN [26].…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, we found changes within three brain regions associated with stress regulation and maternal care: the rostral anteroventral periventricular nucleus (AVPV/PeN), paraventricular hypothalamus (PVN), and medial preoptic area (MPOA) [26]. We also observed changes in CRFR1 co-localization with tyrosine hydroxylase (TH) within select brain regions, particularly the AVPV/PeN [26]. More recently, we reported that hypothalamic oxytocin neurons express CRFR1 only in postpartum female mice [29].…”

Section: Introductionmentioning

confidence: 99%

“…Although our previous study showed differences in CRFR1 between P14 and nulliparous mice [26], this study sought to determine the specific timing of changes in CRFR1 during the postpartum period. We mapped out the changes in CRFR1 across five postpartum time points utilizing a validated bacterial artificial chromosome identified by green fluorescence protein mouse line [30].…”

Section: Introductionmentioning

confidence: 99%

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Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice

et al. 2023

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Introduction: Corticotropin-releasing factor (CRF) and its primary receptor (CRFR1) are critical regulators of behavioral and neuroendocrine stress responses. CRFR1 has also been associated with stress-related behavioral changes in postpartum mice. Our previous studies indicate dynamic changes in CRFR1 levels and coupling of CRFR1 with tyrosine hydroxylase (TH) and oxytocin (OT) neurons in postpartum mice. In this study, we aimed to determine the time course of these changes during the postpartum period. Methods: Using a CRFR1-GFP reporter mouse line, we compared postpartum mice at five time points with nulliparous mice. We performed immunohistochemistry to assess changes in CRFR1 levels and changes in co-expression of TH/CRFR1-GFP and OT/CRFR1-GFP across the postpartum period. Mice were also assessed for behavioral stress responses in the open field test. Results: Relative to nulliparous mice, CRFR1 levels were elevated in the anteroventral periventricular nucleus (AVPV/PeN) but were decreased in the medial preoptic area from postpartum day 1 (P1) through P28. In the paraventricular hypothalamus (PVN), there is a transient decline in CRFR1 mid-postpartum with a nadir at P7. Co-localization of CRFR1 with TH-expressing neurons was also altered with a transient decrease found in the AVPV/PeN at P7 and P14. Co-expression of CRFR1 and oxytocin neurons of the PVN and supraoptic nucleus was dramatically altered with virtually no co-expression found in nulliparous mice, but levels increased shortly after parturition and peaked near P21. A transient decrease in open field center time was found at P7, indicating elevated anxiety-like behavior. Discussion/Conclusion: This study revealed various changes in CRFR1 across the postpartum period, which may contribute to stress-related behavior changes in postpartum mice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice

et al. 2023

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“…Maternal care is crucial for the healthy development of the offspring [17, 18]. During the early stages of life, pup rats are vulnerable to a variety of environmental conditions which might lead, e.g., to long-lasting effects, such as later intensification of stress responses, as has been shown by increased corticosterone levels in adults who experienced a lack of maternal protection [19]. Underlying the neurobiology of maternal behavior in rats, the hypothalamus’s medial preoptic area (MPOA) is a central node in parental control [20].…”

Section: Introductionmentioning

confidence: 99%

Neonatal Anoxia Impacts Rats’ Maternal Behavior and Offspring Development due to Ultrasonic Vocalization’s Impairment

et al. 2022

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Hypoxic-ischemic encephalopathy is a severe clinical condition, among others, affecting the brain after offspring exposure to neonatal anoxia, which causes persistent sensorimotor and cognitive deficits. During peripartum, maternal behaviors are crucial for the healthy development of the offspring. In rats, the vocalization of newborns, around 40 kHz, corresponds to separation calls that encourage their mothers to retrieve them. Alterations in this pattern affect the maternal behavior addressed to the offspring. This study aimed to evaluate the maternal behavior of primiparous rats whose offspring were exposed to neonatal Anoxia in P2 (postpartum day) during the lactation period, to assess mother-pup interactions through the pups' vocalization from P3 to P18. It also intends to quantify eventual neuronal alterations in the mothers' medial preoptic area (MPOA) after the last weaning (P21) through FOS protein expression. Anoxia offspring were found to reduce maternal behaviors towards them, increased frequency of separation calls in the male anoxia group, and reduced vocalization rate in the female anoxia group compared to their respective controls. Body weight gain reduction of males' and females' anoxia was observed. We concluded that anoxia exerts deleterious effects on the vocalization patterns of the pups, with sex differences that alter maternal behavior towards them. Impaired USV makes an additional negative impact on the already noxious effects of neonatal anoxia. Understanding those phenomena apply/contributes to guiding procedures and strategies to mitigate the deleterious outcomes and orient research concerning the complexity of neonatal anoxia events and the influence of maternal care quality concerning the pups, which should also be considered sex differences.

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“…Increased expression of CRF mRNA in the bed nucleus of the stria terminalis (BNST) and central amygdala, but not the PVN in rats (Funk et al, 2006;Jiang S. et al, 2019) and activation of CRF R2-positive neurons in the medial amygdala (Fekete et al, 2009;Ivanova et al, 2021) may explain the manifestation of aggressive behavior in the offspring, as Haller (2018) explained that rivalry aggression and hyperarousaldriven aggression are controlled by the medial amygdala while predatory aggression is controlled by the central amygdala and hypoarousal-associated violent aggression recruits both nuclei. It is important to note that central CRF administration into the lateral ventricle or lateral septum reduces maternal aggression in rodents (Rosinger et al, 2020;De Guzman et al, 2021), suggesting that decreased CRF neurotransmission during lactation is thought to contribute to the attenuated stress response in dams as well as promoting maternal aggression (Gammie et al, 2004;Bosch et al, 2018). Murgatroyd and Nephew (2013) showed that prenatal chronic social stress does not only disrupt maternal behavior but also impair maternal care of offspring.…”

Section: Neuroendocrine Changesmentioning

confidence: 99%

Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance

Mbiydzenyuy

Hemmings²,

Qulu³

2022

Front. Behav. Neurosci.

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Even though studies have shown that prenatal maternal stress is associated with increased reactivity of the HPA axis, the association between prenatal maternal stress and fetal glucocorticoid exposure is complex and most likely dependent on unidentified and poorly understood variables including nature and timing of prenatal insults. The precise mechanisms in which prenatal maternal stress influence neuroendocrine signaling between the maternal-placental-fetal interface are still unclear. The aim of this review article is to bring comprehensive basic concepts about prenatal maternal stress and mechanisms of transmission of maternal stress to the fetus. This review covers recent studies showing associations between maternal stress and alterations in offspring aggressive behavior, as well as the possible pathways for the “transmission” of maternal stress to the fetus: (1) maternal-fetal HPA axis dysregulation; (2) intrauterine environment disruption due to variations in uterine artery flow; (3) epigenetic modifications of genes implicated in aggressive behavior. Here, we present evidence for the phenomenon of intergenerational and transgenerational transmission, to better understands the mechanism(s) of transmission from parent to offspring. We discuss studies showing associations between maternal stress and alterations in offspring taking note of neuroendocrine, brain architecture and epigenetic changes that may suggest risk for aggressive behavior. We highlight animal and human studies that focus on intergenerational transmission following exposure to stress from a biological mechanistic point of view, and maternal stress-induced epigenetic modifications that have potential to impact on aggressive behavior in later generations.

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Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period

Cited by 9 publications

References 97 publications

Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice

Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice

Neonatal Anoxia Impacts Rats’ Maternal Behavior and Offspring Development due to Ultrasonic Vocalization’s Impairment

Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance

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