Alterations in Dry Mass Content of Collagen Fibers in Degenerative Tendinopathy and Tendon-Rupture

Józsa, László; Lehto, Matti; Kvist, M; Bálint, J; Réffy, A

doi:10.1016/s0934-8832(89)80032-0

Cited by 45 publications

(29 citation statements)

References 15 publications

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“…Collagen content increases, but elastin and proteoglycans decrease, resulting in less elasticity. Related to this, water content declines from 80% at birth to approximately 30% in old age (Hess et al 1989, Jozsa et al 1989. Ploetz (1938) and Gillard (Gillard et al 1979) showed the infl uence of mechanical factors on the modulation of extracellular matrix constituents in the tendon.…”

Section: Biochemical Compositionmentioning

confidence: 99%

“…Achilles tendon ruptures are common sports injuries in men with a maximum incidence at 35-40 years. As many as 59% of Achilles tendon ruptures are sustained during sports activities, in contrast to only 2% of other tendon injuries (Jozsa et al 1989). The patients seldom have a history of problems with the Achilles tendon before being injured.…”

Section: Achilles Tendon Rupturesmentioning

confidence: 99%

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BMP treatment for improving tendon repair Studies on rat and rabbit Achilles tendons

Forslund

2002

Acta Orthopaedica Scandinavica

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Section: Biochemical Compositionmentioning

confidence: 99%

Section: Achilles Tendon Rupturesmentioning

confidence: 99%

BMP treatment for improving tendon repair Studies on rat and rabbit Achilles tendons

Forslund

2002

Acta Orthopaedica Scandinavica

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“…These findings indicate that structural alteration is possible to be induced by disintegration of collagen fibrils and disappearance of glycosaminoglycans from extracellular matrix (ECM), subsequent of upregulation of MMPs activity. Although the study period is limited, the tissue culture method is available for investigating cell-ECM interaction in tendons.Tendon, which is dense connective tissue, consist of type I collagen and elastin embedded in a proteoglycan (PG)-water matrix, with collagen accounting for 70% and a miniscle amount of elastin (11,18). These elements, extracellular matrices (ECMs), are produced, synthesized and digested by tenoblasts and tendinocytes (19).…”

mentioning

confidence: 99%

“…Tendon, which is dense connective tissue, consist of type I collagen and elastin embedded in a proteoglycan (PG)-water matrix, with collagen accounting for 70% and a miniscle amount of elastin (11,18). These elements, extracellular matrices (ECMs), are produced, synthesized and digested by tenoblasts and tendinocytes (19).…”

mentioning

confidence: 99%

Structure and component alteration of rabbit Achilles tendon in tissue culture

et al. 2005

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The aim of this study was to investigate alterations of cultured tendon tissues to determine whether tissue culture is a useful method for biological analyses of the tendon. Tendon tissues for tissue culture were isolated from Achilles tendons of rabbits. The tendon segments were placed one segment per well and incubated in growth medium consisting of Dullbecco's modified Eagle's medium supplemented with 5% fetal bovine serum at 37°C in a humidified atmosphere with 5% CO 2 for various periods. The alignment of collagen fibrils was preserved for 48 h, but tendon structure has disintegrated at 96 h. Alcian blue staining and gelatine zymography revealed that proteoglycan markedly diminished and that matrix metalloproteinase (MMPs) activity was upregulated sharply at 72 and 96 h. The ratio of collagen fibrils with large diameter had increased and the mean diameter and mass average diameter value had reached maximum at 48 h. The values then decreased and mean diameters at 72 and 96 h were significantly different from that at 48 h. At 96 h, the ratio of collagen fibrils with small diameters had increased and collagen fibrils with large diameters had disappeared. These findings indicate that structural alteration is possible to be induced by disintegration of collagen fibrils and disappearance of glycosaminoglycans from extracellular matrix (ECM), subsequent of upregulation of MMPs activity. Although the study period is limited, the tissue culture method is available for investigating cell-ECM interaction in tendons.Tendon, which is dense connective tissue, consist of type I collagen and elastin embedded in a proteoglycan (PG)-water matrix, with collagen accounting for 70% and a miniscle amount of elastin (11,18). These elements, extracellular matrices (ECMs), are produced, synthesized and digested by tenoblasts and tendinocytes (19). There is a very intimate relation between the cell and ECM.The best way to understand cell-and-ECM interaction in vitro is to carry out experiments under similar to in vivo conditions, such as tissue culture. The tissue culture method has its advantage to investigate and observe the cell-and-ECM interaction easily. Methods of tissue culture are well established and widely used for the study of blood vessels (34, 38), lungs (26), uterus (3), testis (24) and intestines (21), whereas only a few studies have been reported in tissue culture of tendon (20,23,32). In vitro study of tendon has been mainly demonstrated by cell cultures on plastic plates. If tissue culture method for tendon is established, it will be a useful tool for investigating interaction of cells and ECM in a tendon and alteration in tendon tissue during degen-

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“…El colágeno representa el 30% del peso del tendón fresco y proporciona resistencia a la tensión y flexibilidad a la compresión, torsión o cizallamiento. Se divide entre colágeno tipo I, con diámetro mayor y que representa el 50-80% del peso en seco y tipo II, III y V, con menor diámetro 25,34 Los tendones están compuestos por colágeno principalmente del tipo I y elastina dentro de una matriz extracelular de proteoglicanos siendo el colágeno el 65-80% y la elastina el 1-2% de la masa seca del tendón 42 . En experimentos de laboratorio se observó que si el estiramiento es menor del 4% el tendón vuelve a su posición normal pero si es mayor se va deformando hablándose de que si es mayor al 8% el tendón da signos de rotura 34 .…”

Section: Los Tendones Recuerdo Anátomo-histológicounclassified

Relación entre estructura del pie y características del ligamento rotuliano en jugadores de voleibol

Gonell¹,

Valeriano²

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TÍTULO:RELACIÓN A mi mujer, Rosana y mi hija, Judith, por aguantarme y por saberme perdonar un tiempo que jamás podré devolverles.A mis padres y a mis hermanos por su colaboración en este estudio, a los primeros por estar siempre ahí, como no podía ser de otra manera, apoyándome en cualquiera que fuera mi objetivo sin poner la más mínima traba y a los segundos por considerarlos co-autores de este trabajo por sus colaboraciones artísticas.A Fermín Valera y Francisco Minaya por infundirme el concepto de la fisioterapia invasiva y de la ecografía musculoesquelética.A Pablo Herrera por abrirme las puertas del voleibol y darme la oportunidad de conocer un deporte que, aunque minoritario y pobre materialmente, es rico en humanidad.A todos los jugadores/as de voleibol que me han dejado su cuerpo, por su paciencia y por saber aguantar mi insistencia.A Manuel Camarasa por su ayuda y con quien espero que sigamos con proyectos en común que nos guíen hacia nuevos conocimientos y mejora en nuestra profesión. Resultados y conclusiones. Los sujetos con valores negativos en el test IPP en el pie izquierdo experimentaron un menor riesgo de afectación del tendón. No se detectó ningún tipo de relación entre el rango de dorsiflexión del tobillo y la imagen ecográfica del tendón rotuliano. Los sujetos con puntuaciones bajas en escala VISA-P o mayores puntuaciones en EAV tenían más riesgo de imagen ecográfica alterada. El diámetro antero-posterior del tendón rotuliano, la afectación y/o rotura de los haces de colágeno junto con la vascularización se asociaron con el dolor anterior de rodilla.Palabras clave: Ligamento Rotuliano, Ultrasonografía, Lesiones en Deportes, Factores de Riesgo, Pie, Pronación, Supinación, Voleibol. 10 ABSTRACTIntroduction. Injury sports prevention has been the aim of study due to its relevance in player's life and inability to participate in their sports commitments.Moreover, the increase of sport's requirement makes injury's study an interesting issue for investigation in sport discipline. From physiotherapy can contribute to the decrease of its incidence either from prevention programs or from detection of possible subjects at risk of injury.Objectives. To identify characteristics of the individuals and their sport activity Tabla 10b.-Diámetro antero-posterior a 10mm inferior a polo inferior de la rótula.V. relacionadas con la actividad deportiva. 98Tabla 10c.-Diámetro antero-posterior a 10mm inferior a polo inferior de la rótula.V. relacionadas con la prevención y los buenos hábitos. 99Tabla 10d.-Diámetro antero-posterior a 10mm inferior a polo inferior de la rótula. V. relacionadas con la estructura del pie 9915 Tabla 11a.-Ecogenicedad del tendón rotuliano derecho. Datos sociodemográficos. 101Tabla 11b.-Ecogenicedad del tendón rotuliano derecho.V. relacionadas con la actividad deportiva. 102Tabla 11c.-Ecogenicedad del tendón rotuliano derecho. V. relacionadas con la prevención y los buenos hábitos 103Tabla 11d.-Ecogenicedad del tendón rotuliano derecho.V. relacionadas con la estructura del pie 103Tabla 1...

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Alterations in Dry Mass Content of Collagen Fibers in Degenerative Tendinopathy and Tendon-Rupture

Cited by 45 publications

References 15 publications

BMP treatment for improving tendon repair Studies on rat and rabbit Achilles tendons

BMP treatment for improving tendon repair Studies on rat and rabbit Achilles tendons

Structure and component alteration of rabbit Achilles tendon in tissue culture

Relación entre estructura del pie y características del ligamento rotuliano en jugadores de voleibol

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