Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge

Pan, Zhiyuan; Hu, Yichen; Huang, Zongyu; Han, Ni; Li, Yan; Zhuang, Xiaomei; Yin, Ji‐Ye; Peng, Hui; Gao, Quansheng; Zhang, Wenpeng; Huang, Yong; Cui, Yu‐Jun; Bi, Yujing; Xu, Zhenjiang

doi:10.1007/s11427-021-2056-1

Cited by 27 publications

(12 citation statements)

References 127 publications

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“…This environment also caused anorexia in rats, resulting in weight loss, negative nitrogen balance, intestinal barrier dysfunction, and mucosal injury, thus enhancing bacterial translocation and inducing inflammation (Adak et al, 2014). Pan et al (2022) intestinal tract under simulated high-altitude environment. During this period, the rats ate less, their body weights decreased sharply, and pathological myocardial hypertrophy occurred.…”

Section: Changes In the Intestinal Flora Of The Qinghai-tibet Plateau...mentioning

confidence: 99%

Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

Pan

Bai

et al. 2022

Front. Microbiol.

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The intestinal microbial community is the largest ecosystem in the human body, in which the intestinal flora plays a dominant role and has a wide range of biological functions. However, it is vulnerable to a variety of factors, and exposure to extreme environments at high altitudes, as seen on the Qinghai–Tibet plateau, may cause changes in the structure and function of the host intestinal flora. Conversely, the intestinal flora can help the host adapt to the plateau environment through a variety of ways. Herein, we review the relationship and underlying mechanism between the host intestinal flora and the plateau environment by discussing the characteristics of the plateau environment, its influence on the intestinal flora, and the important role of the intestinal flora in host adaptation to the plateau environment. This review aimed to provide a reference for maintaining the health of the plateau population.

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Section: Changes In the Intestinal Flora Of The Qinghai-tibet Plateau...mentioning

confidence: 99%

Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

Pan

Bai

et al. 2022

Front. Microbiol.

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“…It has been shown that the Firmicutes/Bacteroidetes ratio can be used to reflect the homeostasis of gut microbiota ( Pan et al., 2022 ). We found herein that the FFT reversed the decrease in the Firmicutes/Bacteroidetes ratio in irradiated mice towards the gut microbiota composition of the sham group.…”

Section: Discussionmentioning

confidence: 99%

Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice

Zhang,

Dong,

Zheng

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundIonizing radiation can cause intestinal microecological dysbiosis, resulting in changes in the composition and function of gut microbiota. Altered gut microbiota is closely related to the development and progression of radiation-induced intestinal damage. Although microbiota-oriented therapeutic options such as fecal microbiota transplantation (FMT) have shown some efficacy in treating radiation toxicity, safety concerns endure. Therefore, fecal bacteria-free filtrate transplantation (FFT), which has the potential to become a possible alternative therapy, is well worth investigating. Herein, we performed FFT in a mouse model of radiation exposure and monitored its effects on radiation damage phenotypes, gut microbiota, and metabolomic profiles to assess the effectiveness of FFT as an alternative therapy to FMT safety concerns.ResultsFFT treatment conferred radioprotection against radiation-induced toxicity, representing as better intestinal integrity, robust proinflammatory and anti-inflammatory cytokines homeostasis, and accompanied by significant shifts in gut microbiome. The bacterial compartment of recipients following FFT was characterized by an enrichment of radioprotective microorganisms (members of family Lachnospiraceae). Furthermore, metabolome data revealed increased levels of microbially generated short-chain fatty acids (SCFAs) in the feces of FFT mice.ConclusionsFFT improves radiation-induced intestinal microecological dysbiosis by reshaping intestinal mucosal barrier function, gut microbiota configurations, and host metabolic profiles, highlighting FFT regimen as a promising safe alternative therapy for FMT is effective in the treatment of radiation intestinal injury.

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“…Hypoxia environments affect the intestinal flora and tissue injury, which in turn affects drug absorption, distribution, metabolism and excretion (Li et al, 2015;Pan et al, 2022). Both i.g., and i.v., drug administration achieved high serum Frontiers in Pharmacology frontiersin.org higher plasma drug concentrations in vivo than in the normoxia group.…”

Section: Discussionmentioning

confidence: 99%

Insights into the pharmacodynamics and pharmacokinetics of meldonium after exposure to acute high altitude

Liu¹,

Sui²,

Wang³

et al. 2023

Front. Pharmacol.

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Objective: Meldonium, a well-known cardioprotective drug, has been reported to be protective against pulmonary injury at high altitudes; however, the pharmacodynamics of meldonium in other vital organs under acute high-altitude injury are less investigated and the related pharmacokinetics have not been fully elucidated.Methods and Results: The present study examined the basic pharmacodynamics and pharmacokinetics (PK) in rat exposure to acute high-altitude hypoxia after intragastrical and intravenous pre-administration of meldonium. The results indicate that meldonium can improve acute hypoxia-induced pathological damage in brain and lung tissues, and restore blood biochemistry and routine blood index of heart, liver and kidney tissues under a simulated acute high-altitude environment. Furthermore, compared to the normoxia group, rats exposed to simulated high-altitude hypoxia and premedicated with intragastrical meldonium showed linear kinetics in the dose range of 25–100 mg/kg, with a significantly increase in the area under curve (AUC) and reduced clearance rate. No significant differences in these meldonium of PK parameters were observed with intravenous administration. Additionally, meldonium was involved in the regulation of succinic acid and 3-hydroxypropionic acid.Conclusion: These results will contribute to our understanding of the preclinical PK properties of meldonium and its acute high-altitude protective effects.

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Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge

Cited by 27 publications

References 127 publications

Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice

Insights into the pharmacodynamics and pharmacokinetics of meldonium after exposure to acute high altitude

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