Alterations in hematological and biochemical parameters and DNA status in mice bearing Ehrlich ascites carcinoma cells and treated with cisplatin and cyclophosphamide

Hashem, Mohamed A.; Mahmoud, Essam A.; Abd-Allah, Noura A.

doi:10.1007/s00580-019-03089-5

Cited by 13 publications

(10 citation statements)

References 44 publications

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“…Compared to tumor-bearing mice alone, treatment with Cis (40 mg/Kg) injection, HD-H post-EAC-cells inoculation increased the number of splenocytes significantly, and the number of splenocytes in EAC-bearing mice treated with Cis (40 mg/Kg) was higher than this number in mice bearing tumor and treated with HD-H (100 µg/Kg). The present data werein agreement with the previous studies, which demonstrated increased splenocytes count in tumor-bearing mice treated with chemotherapeutic agents (Merritt et al, 2003;Park et al, 2009;Rosa et al, 2013;Zhu et al, 2019;Hashem et al, 2020).…”

Section: Discussionsupporting

confidence: 94%

“…Treated groups with Cis, HD-H or SH-H showed an increase in the percentages of the late apoptotic EAC-cells, however, the percentage of these cells was higher in HD-H (100 µg/Kg) than those in the group of mice inoculated with EACcells and treated with Cis (40 mg/Kg). Our results were in consistent with previous studies that investigated the number of apoptotic cells in tumor-bearing mice treated with chemotherapeutic agents (Zhivotovsky et al, 2006;Donaghy et al, 2010;Patra and Muthuraman, 2013;Matusiewicz et al, 2018;Zhu et al, 2019;Hashem et al, 2020).…”

Section: Discussionsupporting

confidence: 93%

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In vivo and in vitro antitumor effects of Helix desertorum hemolymph by inducing cell cycle arrest and apoptosis

Ziada

Mona

Basyony

et al. 2021

International Journal of Cancer and Biomedical Research

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It is with great pleasure that I write this editorial to welcome you to the IJCBR. This journal provides a platform for publication of original and reviews research articles, short communications, letter to editor, thesis abstract, conference report, and case studies. These types of publication are directed at the interface of the fields of cancer and biomedical research.The IJCBR relies on a distinguished expert of the Advisory and Editorial Board Members from the top international league covering in depth the related topics. They timely review all manuscripts and maintain highest standards of quality and scientific methodology and ethical concepts. Meanwhile, we take all possible means to keep the time of the publication process as short as possible.I take this chance to welcome your contributions to the IJCBR and have every expectation that it will soon become one of the most respected journals in both the fields of cancer and biomedical research.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

In vivo and in vitro antitumor effects of Helix desertorum hemolymph by inducing cell cycle arrest and apoptosis

Ziada

Mona

Basyony

et al. 2021

International Journal of Cancer and Biomedical Research

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“…In addition, the current study revealed that EAC induced anemia, manifested by significant reductions in RBCs count, hemoglobin concentration, and PCV value, along with a significant elevation in the MCV value and insignificant changes of MCH and MCHC values, indicating the presence of macrocytic normochromic anemia. Similar findings were reported by Hashem et al [ 21 ], who related these effects to the suppressive effect of EAC on erythropoiesis that could result from iron deficiency, hemolytic or myelopathic conditions [ 22 ]. Moreover, the macrocytic normochromic anemia observed in the EAC-bearing mice could be attributed, in part, to the deficiency of folic acid that may be due to EAC-induced thiamine deficiency, which is essential for folic acid metabolism [ 23 , 24 ].…”

Section: Discussionsupporting

confidence: 89%

Protective and Therapeutic Efficacy of Hesperidin versus Cisplatin against Ehrlich Ascites Carcinoma-Induced Renal Damage in Mice

et al. 2022

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This study evaluates the antitumor efficacy of hesperidin (Hesp) versus cisplatin (Cis) in Ehrlich ascites carcinoma (EAC)-bearing mice, as well as its protective effect against Cis-triggered nephrotoxicity. Seventy female mice were allocated into control, Hesp, EAC, Hesp-protected, Hesp-treated, Cis-treated, and Cis+Hesp-treated groups. The inoculation of mice with EAC cells significantly reduced the mean survival time, while significantly increased the body weight, abdominal circumference, ascitic fluid volume, viable tumor cell count, and serum carcinoembryonic antigen, urea and creatinine levels, besides various hematological changes. Additionally, kidney tissue of EAC-bearing mice showed a significant increase in the malondialdehyde level, significant decreases in the reduced glutathione content and catalase activity, marked pathological alterations, and a strong Ki-67 expression with a weak caspase-3 expression in neoplastic cells infiltrating the renal capsule. Conversely, the administration of Hesp and/or Cis to the EAC-bearing mice induced, to various degrees, antitumor responses and alleviated the cytotoxic effects of EAC. In addition to the potent antitumor effect of the concomitant administration of Hesp and Cis, Hesp minimized the renal adverse side effects of Cis. In conclusion, Hesp may open new avenues for safe and effective cancer therapy and could be valuable for enhancing the antitumor potency and minimizing the renal adverse side effects of chemotherapeutic drugs.

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“…Current data revealed that remarkable increase in the relative neutrophil percentage in EAC group compared to the naive control. An increase in neutrophils within EAC-mice could be attributable to acute inflammatory response or stress due to EAC-cell proliferation (Mazumdar et al, 1997;Hashem et al, 2020). Our data showed that EAC-mice treated with cisplatin showed an increase in neutrophil relative percentage compared to EAC-mice alone.…”

Section: Discussionsupporting

confidence: 47%

Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

El-Bolkiny

Salem

El‐Naggar

et al. 2021

International Journal of Cancer and Biomedical Research

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Background: Rosemary (ROLE) and costus (SLRE) have been established to show antioxidant effects. Aim: This study aimed to evaluate the ameliorating effects of ROLE and SLRE to the side-effects induced by cisplatin (CIS) in tumor-bearing mice. Materials and Methods: Extracts of ROLE and SLRE were examined for their phytochemical activities. To ecaluate their anti-tumor effects, mice were inoculated intraperitoneally (i.p.) with 2.5x10 5 Ehrlich ascites carcinoma (EAC) and then treated i.p. with CIS (dose????) at days 3-7 and with ROLE (dose) or SLRE (dose) at days 3-14. Mice were sacrificed on day 14 for CBC and T-cell analyses. Results: Phytochemical analysis revealed that both ROLE and SLRE showed similar antioxidant activities. Treatment of EAC-bearing mice with CIS induced antitumor efficacy of about 90%. Treatment with CIS in combination of ROLE or SLRE did not further enhance the the antitumor activity of CIS. However, co-administration of ROLE or SLRE with CIS increased significantly the antitumor efficacy of CIS. Flow cytometric analysis showed that the numbers of CD4 + and CD8 + T cells were decreased in EAC bearing mice after treatment with CIS. Treatment with both ROLE and SLRE improved the number of these cells. Conclusion: Combinatorial treatment with rosemary and costus can enhance the antitumor activity of CIS while lower its side effects.

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Alterations in hematological and biochemical parameters and DNA status in mice bearing Ehrlich ascites carcinoma cells and treated with cisplatin and cyclophosphamide

Cited by 13 publications

References 44 publications

In vivo and in vitro antitumor effects of Helix desertorum hemolymph by inducing cell cycle arrest and apoptosis

In vivo and in vitro antitumor effects of Helix desertorum hemolymph by inducing cell cycle arrest and apoptosis

Protective and Therapeutic Efficacy of Hesperidin versus Cisplatin against Ehrlich Ascites Carcinoma-Induced Renal Damage in Mice

Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

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