Alterations in metamemory capacity and neural correlates in a subtype of subjective cognitive decline

Li, Qinjie; Sun, Xiaokang; Cui, Liang; Zhong, Yuan; Wang, Beiyun; Miao, Ya; Hu, Xiaochen; Guo, Qihao

doi:10.1016/j.nicl.2022.103255

Cited by 3 publications

(4 citation statements)

References 66 publications

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“…Meanwhile, the lack of complementary associations within the SCD groups may be due to ceiling effects on the SCD-plus measure. Future studies should attempt to stratify SCD subjects into different levels of self-awareness of cognition and investigate the related FC changes (e.g., using metacognition approaches 12 ).…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, it is unclear whether the current SCD research definition is equally suited for Eastern populations, or needs tailoring regarding cultural appropriateness and specificity for the target population 7 . To harmonize SCD research across cultures, Sino‐German conferences took place (2016, 2017, 2019), 8 and Chinese SCD cohorts were established using a contemporary SCD research definition 9–12 . Beyond adherence to the general SCD definition, various SCD‐related features 1,2 were coded, and their predictive value for amyloid burden was tested in Chinese SCD subjects 13,14 .…”

Section: Introductionmentioning

confidence: 99%

“…7 To harmonize SCD research across cultures, Sino-German conferences took place (2016, 2017, 2019), 8 and Chinese SCD cohorts were established using a contemporary SCD research definition. [9][10][11][12] Beyond adherence to the general SCD defini-tion, various SCD-related features 1,2 were coded, and their predictive value for amyloid burden was tested in Chinese SCD subjects. 13,14 Still, comparability between SCD individuals from both countries is unknown.…”

Section: Introductionmentioning

confidence: 99%

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Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts

Jiang

Daamen

et al. 2023

Alzheimer's & Dementia

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INTRODUCTIONIt remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds and whether the network alterations are associated with an amyloid burden.METHODSCross‐sectional resting‐state functional magnetic resonance imaging connectivity (FC) and amyloid‐positron emission tomography (PET) data from the Chinese Sino Longitudinal Study on Cognitive Decline and German DZNE Longitudinal Cognitive Impairment and Dementia cohorts were analyzed.RESULTSLimbic FC, particularly hippocampal connectivity with right insula, was consistently higher in SCD than in controls, and correlated with SCD‐plus features. Smaller SCD subcohorts with PET showed inconsistent amyloid positivity rates and FC–amyloid associations across cohorts.DISCUSSIONOur results suggest an early adaptation of the limbic network in SCD, which may reflect increased awareness of cognitive decline, irrespective of amyloid pathology. Different amyloid positivity rates may indicate a heterogeneous underlying etiology in Eastern and Western SCD cohorts when applying current research criteria. Future studies should identify culture‐specific features to enrich preclinical Alzheimer's disease in non‐Western populations.Highlights Common limbic hyperconnectivity across Chinese and German subjective cognitive decline (SCD) cohorts was observed. Limbic hyperconnectivity may reflect awareness of cognition, irrespective of amyloid load. Further cross‐cultural harmonization of SCD regarding Alzheimer's disease pathology is required.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts

Jiang

Daamen

et al. 2023

Alzheimer's & Dementia

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“…Similarly, the relation with thalamic volume highlights an area associated with recollection and familiarity, acting as a hub between medial prefrontal and hippocampal regions (Thielen et al 2015 ), and hippocampal volume, an area associated with consolidation of new information (Scoville and Milner 1957 ; Squire and Zola 1998 ), with retention of information in the PD group. Thus, within the mnemonic network for episodic memory processes, despite a similar deficit phenotype, the HIV and PD groups exhibited different pathogenic patterns—with PD-associated vulnerability of the hippocampus for retention of learned information (see, e.g., Tambini and Davachi 2013 ) and neural substrates beyond the role of the hippocampus including HIV-associated vulnerability in the orbitofrontal cortex, an area with bi-directional connections to medial temporal regions, relevant to learning and encoding (Frey and Petrides 2002 ; Li 2022 ) and PD-associated vulnerability in the superior frontal cortex, a region associated with top-down control for learning and encoding of complex material (Ritchey et al 2013 ; Wing et al 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Episodic memory deficit in HIV infection: common phenotype with Parkinson’s disease, different neural substrates

et al. 2023

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Episodic memory deficits occur in people living with HIV (PLWH) and individuals with Parkinson’s disease (PD). Given known effects of HIV and PD on frontolimbic systems, episodic memory deficits are often attributed to executive dysfunction. Although executive dysfunction, evidenced as retrieval deficits, is relevant to mnemonic deficits, learning deficits may also contribute. Here, the California Verbal Learning Test-II, administered to 42 PLWH, 41 PD participants, and 37 controls, assessed learning and retrieval using measures of free recall, cued recall, and recognition. Executive function was assessed with a composite score comprising Stroop Color-Word Reading and Backward Digit Spans. Neurostructural correlates were examined with MRI of frontal (precentral, superior, orbital, middle, inferior, supplemental motor, medial) and limbic (hippocampus, thalamus) volumes. HIV and PD groups were impaired relative to controls on learning and free and cued recall trials but did not differ on recognition or retention of learned material. In no case did executive functioning solely account for the observed mnemonic deficits or brain-performance relations. Critically, the shared learning and retrieval deficits in HIV and PD were related to different substrates of frontolimbic mnemonic neurocircuitry. Specifically, diminished learning and poorer free and cued recall were related to smaller orbitofrontal volume in PLWH but not PD, whereas diminished learning in PD but not PLWH was related to smaller frontal superior volume. In PD, poorer recognition correlated with smaller thalamic volume and poorer retention to hippocampal volume. Although memory deficits were similar, the neural correlates in HIV and PD suggest different pathogenic mechanisms.

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Subjective cognitive decline exhibits alterations of resting-state phase-amplitude coupling in precuneus

Cheng,

Hung,

Chao

et al. 2023

Clinical Neurophysiology

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Alterations in metamemory capacity and neural correlates in a subtype of subjective cognitive decline

Cited by 3 publications

References 66 publications

Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts

Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts

Episodic memory deficit in HIV infection: common phenotype with Parkinson’s disease, different neural substrates

Subjective cognitive decline exhibits alterations of resting-state phase-amplitude coupling in precuneus

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