2016
DOI: 10.1002/hbm.23104
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Alterations in neural systems mediating cognitive flexibility and inhibition in mood disorders

Abstract: Impairment in mental flexibility may be a key component contributing to cardinal cognitive symptoms among mood disorders patients, particularly thought control disorders. Impaired ability to switch from one thought to another might reflect difficulties in either generating new mental states, inhibiting previous states, or both. However, the neural underpinnings of impaired cognitive flexibility in mood disorders remain largely unresolved. We compared a group of mood disorders patients (n = 29) and a group of m… Show more

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Cited by 26 publications
(22 citation statements)
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“…This exclusive mask therefore removed all voxels reaching Neuropsychologia 93 (2016) 229-241 significance in the U > P contrast for one group that overlapped with significant voxels in the U > P contrast for the other group; the more liberal the exclusive mask threshold, the more conservative the masking procedure. Similar analyses using exclusive masking procedures have been used in other clinical studies (e.g., Desseilles, et al, 2009;Piguet, et al, 2016;Schwartz, et al, 2008;van der Stouwe et al, 2015) and provide a rigorous way to delineate group differences characterised by unique activation patterns between patient and control cohorts. Group differences were also assessed by formal interaction contrasts at the whole-brain level, using small volume correction (SVC) based on regions of interest (ROI) activated in the main effect of unpleasant versus pleasant stimuli for patients and controls.…”
Section: Imaging Data Analysismentioning
confidence: 99%
“…This exclusive mask therefore removed all voxels reaching Neuropsychologia 93 (2016) 229-241 significance in the U > P contrast for one group that overlapped with significant voxels in the U > P contrast for the other group; the more liberal the exclusive mask threshold, the more conservative the masking procedure. Similar analyses using exclusive masking procedures have been used in other clinical studies (e.g., Desseilles, et al, 2009;Piguet, et al, 2016;Schwartz, et al, 2008;van der Stouwe et al, 2015) and provide a rigorous way to delineate group differences characterised by unique activation patterns between patient and control cohorts. Group differences were also assessed by formal interaction contrasts at the whole-brain level, using small volume correction (SVC) based on regions of interest (ROI) activated in the main effect of unpleasant versus pleasant stimuli for patients and controls.…”
Section: Imaging Data Analysismentioning
confidence: 99%
“…A key feature of this method is the selection of a seed region of interest (ROI), with which the rest of the brain co-activates under different spatial configurations at specific time points. Here we selected the bilateral precuneus as seed, based on its central contribution to the default mode network (DMN; Utevsky et al, 2014) as well as its role in selfconsciousness (Vogt and Laureys 2005), memory (Cavanna and Trimble 2006), and attentional flexibility (Piguet et al 2016). Moreover, the precuneus was also found to show higher activity during affective vs. neutral movies in our main GLM analysis (see below and Supplementary Figure S1.A).…”
Section: Dynamic Functional Connectivity Of Dmn Nodes Defined By Capsmentioning
confidence: 99%
“…In particular, negative affect may impair the efficiency of high-level cognitive processes and reduce cognitive control (Hilt et al 2014). Further, experiencing negative emotions has been associated with cognitive inflexibility (Davis and Nolen-Hoeksema 2000) and difficulties in mental switching (Piguet et al 2010(Piguet et al , 2016. A better understanding of such influences of affective states on cognitive control and mental functions is therefore warranted to elucidate mechanisms by which emotions and moods can steer behavior in adaptive or maladaptive manners, in both health and disease.…”
Section: Introductionmentioning
confidence: 99%
“…Franklin et al (2013) show that the presence of interesting thoughts during mind wandering increases positive Despite such helpful roles they play in our life, some researchers argue that mind wandering has an emotional cost in terms of its correlation with unhappiness and negative mood (Killingsworth & Gilbert, 2010;Mor & Winquist, 2002;Mrazek, Phillips, Franklin, Broadway & Schooler, 2013;Perkins, Arnone, Smallwood, & Mobbs, 2015;Poerio, Totterdell, & Miles, 2013;Smallwood, Fitzgerald, Miles & Phillips, 2009;Stawarczyk, Majerus, & D'Argembeau, 2013). There are also some studies which address the role of the DN in depressive disorders (e.g., Berman et al, 2011;Hahn et al, 2012;Kaiser, Andrews-Hanna, Wager & Pizzagalli, 2015;Marchetti, Koster & De Raedt, 2013;Marchetti, Koster, Sonuga-Barke, & De Raedt, 2012;McCabe & Mishor, 2011;Piguet et al, 2016;Posner et al, 2013;Simon & Engström, 2015). In the next sections, we delve deeper into the nature of such a correlation.…”
Section: Adaptive Functions Of Dn Activity and Mind Wanderingmentioning
confidence: 99%
“…However, if executive resources become engaged in functions such as maintaining detachment from or restraining elaboration of thoughts, despite increased DN activity, negative mood or depression will not occur. Finally, the lack of metacognition and decreased activity in the FPCN along with increased DN activity may be accompanied by negative mood and depression, probably due to poor cognitive control Marchetti et al, 2013;McCabe & Mishor, 2011;Piguet et al, 2016;Posner et al, 2013;Simon & Engström, 2015). For example, some researchers Marchetti et al, 2013) argue that rumination and cognitive reactivity, as two kinds of cognitive risk factors for depression, are outcomes of DN dysfunctions.…”
Section: Mind Wandering and The Dn Are Correlated With Negative Mood mentioning
confidence: 99%