Alterations in non-type I collagen biomarkers in osteogenesis imperfecta

Nicol, Lindsey; Morar, Patrick; Wang, Ying; Henriksen, Kim; Sun, Shenghua; Karsdal, Morten A.; Smith, Rosamund C.; Nagamani, Sandesh C.S.; Shapiro, Jay R.; Lee, Brendan; Orwoll, Eric S.

doi:10.1016/j.bone.2018.09.024

Cited by 15 publications

(3 citation statements)

References 59 publications

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“…Collagen types I, II, III, V, and XI are able to form fibrils that are necessary for structural support and resistance to mechanical stress in connective tissues [16,17]. Type I collagen is the most abundant form and is mainly present in the tendons and skin [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration

2022

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Marine organisms harbor numerous bioactive substances that can be utilized in the pharmaceutical and cosmetic industries. Scientific research on various applications of collagen extracted from these organisms has become increasingly prevalent. Marine collagen can be used as a biomaterial because it is water soluble, metabolically compatible, and highly accessible. Upon review of the literature, it is evident that marine collagen is a versatile compound capable of healing skin injuries of varying severity, as well as delaying the natural human aging process. From in vitro to in vivo experiments, collagen has demonstrated its ability to invoke keratinocyte and fibroblast migration as well as vascularization of the skin. Additionally, marine collagen and derivatives have proven beneficial and useful for both osteoporosis and osteoarthritis prevention and treatment. Other bone-related diseases may also be targeted by collagen, as it is capable of increasing bone mineral density, mineral deposition, and importantly, osteoblast maturation and proliferation. In this review, we demonstrate the advantages of marine collagen over land animal sources and the biomedical applications of marine collagen related to bone and skin damage. Finally, some limitations of marine collagen are briefly discussed.

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Section: Introductionmentioning

confidence: 99%

Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration

2022

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“…Degradation biomarkers are further divided into Col-I neoepitope (C1M), C-terminal telopeptide of Col-I (CTX-I), and Col-I-derived crosslinked carboxy-terminal telopeptide (ICTP). Furthermore, synthesis biomarkers are broken down into carboxy-terminal propeptides of pro Col-I (PICP) and amino-terminal propeptides of pro Col-I (PINP) [ 98 ].…”

Section: Biomarkers For Col-imentioning

confidence: 99%

Current Insights into Collagen Type I

2021

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Collagen type I (Col-I) is unique due to its high biocompatibility in human tissue. Despite its availability from various sources, Col-I naturally mimics the extracellular matrix (ECM) and generally makes up the larger protein component (90%) in vasculature, skin, tendon bone, and other tissue. The acceptable physicochemical properties of native Col-I further enhance the incorporation of Col-I in various fields, including pharmaceutical, cosmeceutical, regenerative medicine, and clinical. This review aims to discuss Col-I, covering the structure, various sources of availability, native collagen synthesis, current extraction methods, physicochemical characteristics, applications in various fields, and biomarkers. The review is intended to provide specific information on Col-I currently available, going back five years. This is expected to provide a helping hand for researchers who are concerned about any development on collagen-based products particularly for therapeutic fields.

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“…Although there are differences between collagen and collagen peptides, they are closely related. Collagen is the parent protein of collagen peptides, while collagen peptides are low molecular weight fragments produced after collagen is biologically processed [6][7][8]. Fish collagen and terrestrial animal collagen amino acid structure is similar, with good water solubility, biosafety, biodegradability, etc, and its living environment is relatively clean, in the control of viruses, cross-infection and other risks than the terrestrial animals have obvious advantages and is considered to be an important source of medical collagen replacement [9,10].…”

Section: Introductionmentioning

confidence: 99%

Studies on Extraction and Biomedical Application of Marine Collagen

Juan

2024

AJBSR

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Collagen is a structural tissue protein and is a major protein component of the extracellular matrix and connective tissues of animals. Collagen is relatively abundant in mammals and is mainly found in the extracellular matrix (ECM) of fibrous connective tissues, where it has properties such as ductility and flexibility [4]. Collagen is a protofibre and the connective tissue is rich in different types of collagen, which are classified as types I, II, III, V and XI [5]. Type I collagen is the most common and abundant type of collagen found in mammalian tendons and skin. Collagen peptides are transparent collagen extracts consisting of two or more amino

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Alterations in non-type I collagen biomarkers in osteogenesis imperfecta

Cited by 15 publications

References 59 publications

Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration

Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration

Current Insights into Collagen Type I

Studies on Extraction and Biomedical Application of Marine Collagen

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