Alterations in osmotic fragility of the red blood cells in hypo- and hyperthyroid patients

Asl, Saleh Zahedi; Brojeni, N. Khalili; Ghasemi, Asghar; faraji, fardin; Mahdi, Hedayati

doi:10.1007/bf03345674

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…This results in decreased MCV and MCH values. Moreover, enhanced erythrocyte osmotic fragility and oxidative stress lead to precocious haemolysis (30). Thus, although total red cell mass is increased in thyrotoxic patients, HGB and HTC are usually low due to a concomitant increase in plasma volume (5).…”

Section: Discussionmentioning

confidence: 99%

Changes in serum hepcidin according to thyrometabolic status in patients with Graves’ disease

Krygier

Szczepanek‐Parulska

Filipowicz

et al. 2020

Endocrine Connections

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Introduction:Hepcidin is an acute-phase protein and a key regulator of iron homeostasis. Anaemia frequently occurs in patients with thyroid dysfunction, and hepcidin may be a potential link. Objectives: Prospective assessment of hepcidin serum concentration and other parameters related to Fe homeostasis in hyperthyroid patients in the course of GD at diagnosis and during remission. Patients and Methods: Out of the 70 patients recruited, 42 (32 women, 10 men), aged 42.5 ± 15.1 years, met the inclusion criteria. Clinical and biochemical assessment, including hepcidin measurement by ELISA, was performed at baseline (T0) and after restoration of euthyroidism (T1). Results: Hepcidin concentration at T0 in the 24 patients who completed the study was significantly higher than the value during euthyroidism (28.7 (8.1-39.4) ng/mL vs 7.9 (4.3-12.9) ng/mL, P < 0.001). Hepcidin level was most significantly correlated with ferritin (rho = 0.723) in women at T0. In both men (377 (171-411) vs 165 (84-237) ng/mL, P = 0.001) and women (84 (23-104) vs 35 (16-64) ng/mL, P = 0.001), a significant decrease in ferritin level was demonstrated following therapy. A significant (P < 0.001) increase in mean corpuscular volume (MCV) (83.5 (82.5-87.1) vs 89.5 (88.8-90.0) fL) and mean concentration of haemoglobin (MCH) (29.0 (28.0-29.4) vs 30.4 (29.5-31.1) pg) was observed. Conclusions: Hepcidin and ferritin decrease significantly during the transition from a hyperthyroid state to euthyroidism in patients with GD. The observed changes occur in parallel to iron homeostasis fluctuations. During the transition from the hyperthyroid state to euthyroidism, the improvement of haematological status is reflected mainly by the increase in MCV and MCH. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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Section: Discussionmentioning

confidence: 99%

Changes in serum hepcidin according to thyrometabolic status in patients with Graves’ disease

Krygier

Szczepanek‐Parulska

Filipowicz

et al. 2020

Endocrine Connections

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“…We consider two examples from previously published data: serum magnesium levels in 12–16 year old girls (with normal distribution, n = 30) (13) and serum thyroid stimulating hormone (TSH) levels in adult control subjects (with non-normal distribution, n = 24) (14). SPSS provides the K-S (with Lilliefors correction) and the Shapiro-Wilk normality tests and recommends these tests only for a sample size of less than 50 (8).…”

Section: Testing Normality Using Spssmentioning

confidence: 99%

Normality Tests for Statistical Analysis: A Guide for Non-Statisticians

Ghasemi¹,

Zahediasl²

2012

Int J Endocrinol Metab

2,904

1,606

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“…However, for subclinical and overt hyperthyroidism several pathways have been proposed. Hyperthyroidism might be associated with anemia via reduced erythrocyte survival due to altered iron metabolism and utilization, enhanced oxidative stress and increased haemolysis (28,29). Thyroid hormones stimulate energy metabolism, resulting in an enhanced requirement of oxygen delivery to the tissues speeding up destructive processes.…”

Section: Advance Articlementioning

confidence: 99%

The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data

Wopereis

Puy

Heemst

et al. 2018

The Journal of Clinical Endocrinology &Amp; Metabolism

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Alterations in osmotic fragility of the red blood cells in hypo- and hyperthyroid patients

Abstract: Alteration in osmotic fragility is seen in patients with hyperthyroidism; however, anemia reported in hypo- or hyperthyroid patients is not due to high osmotic fragility of red blood cells and other causes need to be investigated.

Cited by 10 publications

References 31 publications

Changes in serum hepcidin according to thyrometabolic status in patients with Graves’ disease

Changes in serum hepcidin according to thyrometabolic status in patients with Graves’ disease

Normality Tests for Statistical Analysis: A Guide for Non-Statisticians

The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data

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