Alterations in plasma L-arginine and methylarginines in heart failure and after heart transplantation

Lundgren, Jakob; Sandqvist, Anna; Hedeland, Mikael; Bondesson, Ulf; Wikström, Gerhard; Rådegran, Göran

doi:10.1080/14017431.2018.1459823

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Putrescine is an intermediate metabolite of the urea cycle. Fumarate is formed in the urea cycle, thus linking the urea cycle to the TCA cycle which involves the glucose aerobic oxidation and the major pathways of fat and amino acid metabolisms (Zou et al, 2015;Lundgren et al, 2018). Our results suggested that energy production during aerobic respiration was suppressed in rats with blood stasis.…”

Section: Discussionmentioning

confidence: 65%

Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach

Sun

et al. 2021

Front. Pharmacol.

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The combined use of Panax notoginseng saponins (PNS)–based drugs and aspirin (ASA) to combat vascular diseases has achieved good clinical results. In this study, the superior efficacy was observed via the combined use of PNS and ASA on acute blood stasis rats, and untargeted metabolomics was performed to holistically investigate the therapeutic effects of coupling application and its regulatory mechanisms. The combined use of PNS and ASA exhibited better improvement effects when reducing the evaluated hemorheological indicators (whole blood viscosity, plasma viscosity, platelet aggregation, and fibrinogen content) in the blood stasis rats vs. single use of PNS or ASA at the same dose. The combined use of both drugs was the most effective application method, as shown by the relative distance in partial least-squares discriminant analysis score plots. Twelve metabolites associated with blood stasis were screened as potential biomarkers and were mainly involved in amino acid metabolism, lipid metabolism, and energy metabolism. After coherently treated with PNS and ASA, the altered metabolites could be partially adjusted to be closer to normal levels than single use. The collective results revealed that PNS could cooperate with ASA to treat blood stasis and provided a scientific explanation for the superior efficacy of their combined use.

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Section: Discussionmentioning

confidence: 65%

Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach

Sun

et al. 2021

Front. Pharmacol.

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“…Over recent years, it has been widely used in immunology and oncology [22,23]. Endothelial dysfunction is an important pathophysiological mechanism of developing HF and its decompensation, including disruption of the nitric oxide (NO) pathway [26]. The L-arginine-NO pathway is a complex system that affects vasomotor tone, cell adhesion, platelet aggregation, cell proliferation and angiogenesis [27].…”

Section: Problem Statement and Analysis Of The Latest Researchmentioning

confidence: 99%

Changes in the Levels of Modern Biomarkers in Patients with Decompensated Heart Failure After Myocardial Infarction Under the Influence of Treatment with Succinic Acid and Arginine Preparations

Levandovska

2019

Galician med. j.

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The prevalence of heart failure in Europe and worldwide is high. This syndrome is a common cause of hospitalization and has a significant impact on morbidity, mortality and healthcare costs in highly developed countries. The study of biomarkers in heart failure is of wide interest as they can improve diagnosis, predict the development of heart failure and its decompensation, and help in assessing treatment outcomes. The objective of the research was to study the feasibility of using multiple biomarker strategy for diagnosing decompensated heart failure in the post-infarction period and to assess changes in these markers after treatment with succinic acid and arginine preparations. Materials and Methods. There were examined 120 patients with Q-QS wave and non-Q wave myocardial infarction complicated by decompensated heart failure. All the patients were divided into 2 groups (depending on Q-QS wave and non-Q wave myocardial infarction) and 4 subgroups (depending on rehabilitation therapy) being homogenous by age and gender. Results. When studying the dynamics of changes in blood level of N-terminal pro-B-type brain natriuretic peptide and ST2, there was observed its significant reduction in all the patients with prior Q-QS wave myocardial infarction complicated by decompensated heart failure after treatment. The most significant changes were observed in the patients of Group IV who, on the background of basic therapy, received succinic acid and arginine preparations according to the proposed scheme. The combined use of arginine preparations and succinic acid in combination therapy for decompensated heart failure secondary to prior Q-QS wave myocardial infarction allowed reducing blood levels of N-terminal pro-B-type brain natriuretic peptide under conditions of graded exercises. Similar tendencies were observed when determining this indicator in the patients with non-Q wave myocardial infarction complicated by decompensated heart failure after rehabilitation treatment. Conclusions. The use of succinic acid and arginine preparations when treating the patients with prior Q-QS wave and non-Q wave myocardial infarction complicated by decompensated heart failure allowed us to significantly reduce the level of immunological enzymes such as N-terminal pro-B-type brain natriuretic peptide and ST2, which indicate the presence and development of decompensated heart failure after myocardial infarction.

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“…73 Additionally, the use of the L-arginine to ADMA ratio for evaluating postoperative outcome in patients after heart transplant has been reported. 74 For Chagas disease, Carbajosa et al 75 demonstrated reduced plasmatic levels of L-arginine in mice during acute infection and increased survival rates when the mice were supplemented with 3.75 mg/kg of L-arginine in drinking water. 75 Based on this previous work, the role of the L-arginine to ADMA ratio as indicator of heart failure in Chagasic patients has been proposed.…”

Section: Markers Of Vascular Function In Chronic Chagasic Cardiomyopathymentioning

confidence: 99%

Treatment of Chronic Chagasic Patients: Is Killing the Parasite the Only Option?

Rodríguez-Angulo

2018

EMJ Cardiol

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Chagas disease is a tropical illness characterised by arrhythmias, heart failure, and eventually death. In approximately 10–30% of patients, chronic disease appears 10–30 years after infection onset. One of the biggest challenges for treatment is how to manage disease progression during the non-symptomatic phase to avoid the most life-threatening consequences of Chagas disease. The aim of this review is to evaluate the empirical rationale for an alternative therapy based on pathophysiological mechanisms that lead to chronic cardiac pathology and that have the possibility of evaluation through serological markers. The author identifies L-arginine serum levels, IL-2, and short-form Cha autoantibodies as possible markers for Chagas disease and discusses the reports regarding the therapeutic potential of amiodarone and angiotensin-converting enzyme inhibitors to modulate the electrophysiological, inflammatory, and vascular disturbances that lead to symptomatic Chagas disease. This review considers this discussion to improve the comprehension of therapeutic alternatives based on the vast literature detailing Chagas disease’s pathophysiology.

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Alterations in plasma L-arginine and methylarginines in heart failure and after heart transplantation

Cited by 5 publications

References 30 publications

Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach

Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach

Changes in the Levels of Modern Biomarkers in Patients with Decompensated Heart Failure After Myocardial Infarction Under the Influence of Treatment with Succinic Acid and Arginine Preparations

Treatment of Chronic Chagasic Patients: Is Killing the Parasite the Only Option?

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