1961
DOI: 10.1126/science.133.3457.1014
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Alterations in Sialic Acid Content of Human Transferrin

Abstract: Starch gel electrophoresis of human transferrin treated with neuraminidase revealed a pattern of five bands whose intensities varied with neuraminidase concentration. Sialic acid analysis after starch block electrophoresis suggested that the bands represented the stepwise removal of sialic acid from the transferrin molecule. Evidence was also obtained for the purification of a particular genetic transferrin variant

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Cited by 58 publications
(19 citation statements)
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“…A reduction in the number of bands of low molecular weight plasma glycoproteins observed on starch gel electrophoresis due to enzymatic removal of its sialic acid has been reported earlier for ,82-mucoid (13,14), haptoglobins (15), and transferrin (16) and recently for a1-acid glycoprotein (2) and Zn-and Ba-a2-glycoproteins (17)(18)(19). In contrast, the starch gel electrophoretic patterns of the different cholinesterases do not change upon digestion with neuraminidase (20,21).…”
Section: Discussionmentioning
confidence: 87%
“…A reduction in the number of bands of low molecular weight plasma glycoproteins observed on starch gel electrophoresis due to enzymatic removal of its sialic acid has been reported earlier for ,82-mucoid (13,14), haptoglobins (15), and transferrin (16) and recently for a1-acid glycoprotein (2) and Zn-and Ba-a2-glycoproteins (17)(18)(19). In contrast, the starch gel electrophoretic patterns of the different cholinesterases do not change upon digestion with neuraminidase (20,21).…”
Section: Discussionmentioning
confidence: 87%
“…Essentially two models for the magnetic field regime have been proposed to explain the transient decreases. Both the 'Magnetic tongue' model that has been developed by Dorman (1957) and Gold (1959) in which the magnetic field in the expanding cloud is stretched in the form of an ordered loop structure at the Earth and the 'Blast wave model' proposed by Parker (1961) in which the shock wave ahead of the plasma cloud plays a dominant role in producing transient decreases at the earth can qualitatively explain the Forbush decrease effects. Figure 38 shows the artistic sketch of the two models for the interplanetary magnetic field clouds proposed by Gold and Parker.…”
Section: Introductionmentioning
confidence: 99%
“…which corresponds to conservation of the whole energy behind the shock surface (blast wave) (Parker, 1961;Dryer, 1974;Dryer, et al, 1984). The observed dependence V s on r in the case of high speed shock waves is as a rule stronger than (3).…”
Section: Introductionmentioning
confidence: 91%
“…We shall use the perturbation method for the investigation of evolution of shock wave. Neglecting the turbulent terms in (13) for the zero approximation we obtain for the spherical case the known scaling solution (Parker, 1961) …”
Section: Turbulent Deceleration Of the Shock Wavementioning
confidence: 99%
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