Alterations in the ability of the bovine pituitary gland to secrete gonadotropins in vitro during the first follicle-stimulating hormone increase of the estrous cycle and in response to exogenous steroids

Lane, Elizabeth A.; Padmanabhan, Vasantha; Roche, J. F.; Crowe, M.A.

doi:10.1016/j.domaniend.2004.09.001

Cited by 7 publications

(2 citation statements)

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“…E2 affects LH synthesis and release [31] and FSH release [7,41]. Furthermore, E2 plays an important role in the expression of estrous behavior (reviewed in [11]).…”

Section: Estradiolmentioning

confidence: 99%

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

Bôer

Stötzel

Röblitz

et al. 2011

Journal of Theoretical Biology

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Bovine fertility is the subject of extensive research in animal sciences, especially because fertility of dairy cows has declined during the last decades. The regulation of estrus is controlled by the complex interplay of various organs and hormones. Mathematical modeling of the bovine estrous cycle could help in understanding the dynamics of this complex biological system. In this paper we present a mechanistic mathematical model of the bovine estrous cycle that includes the processes of follicle and corpus luteum development and the key hormones that interact to control these processes. The model generates successive estrous cycles of 21 days, with three waves of follicle growth per cycle. The model contains 12 differential equations and 54 parameters. Focus in this paper is on development of the model, but also some simulation results are presented, showing that a set of equations and parameters is obtained that describes the system consistent with empirical knowledge. Even though the majority of the mechanisms that are included in the model are based on relations that in literature have only been described qualitatively (i.e. stimulation and inhibition), the output of the model is surprisingly well in line with empirical data. This model of the bovine estrous cycle could be used as a basis for more elaborate models with the ability to study effects of external manipulations and genetic differences. AMS MSC 2000: 92C42, 92C30, 90C31, 65L09

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“…E2 affects LH synthesis and release [31] and FSH release [7,41]. Furthermore, E2 plays an important role in the expression of estrous behavior (reviewed in [11]).…”

Section: Estradiolmentioning

confidence: 99%

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

Bôer

Stötzel

Röblitz

et al. 2011

Journal of Theoretical Biology

View full text Add to dashboard Cite

show abstract

“…It was noted that anti-progestins RU486 and ZK98299 affected levels of serum FSH and FSHβ mRNA in a similar manner during proestrus, while they showed divergent patterns on estrus indicating that the active functional state of progesterone receptor/transcriptional activation complex is different during the two cyclic phases (Ringstrom et al 1997). A study also indicated that estrogen and inhibin both differentially modulate the estrus stage - dependent increased secretion of FSH in bovine pituitary cells (Lane, et al 2005).…”

Section: Regulation Of Fsh Secretionmentioning

confidence: 99%