2003
DOI: 10.1046/j.1460-9568.2003.02641.x
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Alterations in the intrauterine environment by glucocorticoids modifies the developmental programme of the auditory system

Abstract: Prenatal exposure to excessive glucocorticoids alters the programming of the metabolic and endocrine balance of various organs, including the nervous system. In the present study, prenatal glucocorticoid treatment was shown to increase the susceptibility of the inner ear to acoustic noise trauma in adult life. Acute auditory brainstem response thresholds were not different between the age-matched groups. However, when measured at 48 h and 4 weeks postexposure, the dexamethasone (DEX)-treated rats showed little… Show more

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Cited by 59 publications
(54 citation statements)
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“…Várias pesquisas relataram os efeitos indesejáveis dos glicocorticóides administrados nas fases finais da gestação (Canlon et al 2003, Martins et al 2003, Scavo et al 2003. Os resultados da presente pesquisa demonstraram que a administração da dexametasona na dosagem de 0,8mg/ dia/animal nos cinco primeiros dias de prenhez não afetou o número e a morfologia dos sítios de implantação.…”
Section: Discussionunclassified
See 1 more Smart Citation
“…Várias pesquisas relataram os efeitos indesejáveis dos glicocorticóides administrados nas fases finais da gestação (Canlon et al 2003, Martins et al 2003, Scavo et al 2003. Os resultados da presente pesquisa demonstraram que a administração da dexametasona na dosagem de 0,8mg/ dia/animal nos cinco primeiros dias de prenhez não afetou o número e a morfologia dos sítios de implantação.…”
Section: Discussionunclassified
“…Além disso, a literatura relata que a exposição excessiva aos glicocorticóides nas fases finais da prenhez pode produzir efeitos indesejáveis na formação da placenta e em vários órgãos da prole (Canlon et al 2003, Martins et al 2003, Scavo et al 2003. Porém não se sabe ao certo qual o efeito da dexametasona sobre desenvolvimento placentário, quando administrada apenas no início da prenhez.…”
Section: Introductionunclassified
“…This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited (6) and increase in threshold of hearing (5). Furthermore, if these animals are affected by ototoxic agents, they will be harmed even more (7). Animals with a history of stress over the fetal period also show greater involvement of the afferent auditory pathways (7).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, if these animals are affected by ototoxic agents, they will be harmed even more (7). Animals with a history of stress over the fetal period also show greater involvement of the afferent auditory pathways (7). Of other consequences of fetal stress, impaired sensory gating (8), severe startle reflex (9), dendritic atrophy of auditory cortex (10), atrophy of auditory neurons in IC (11), and neuronal morphology defects in different parts of the central auditory nervous system (CANS) (11) can be mentioned.…”
Section: Introductionmentioning
confidence: 99%
“…The mechanism of dexamethasone toxicity to the immature newborn needs further translational study using in vitro cell cultures and animal models, that are underway, to complement existing studies. 22,23 The correlation of dexamethasone treatment of ELBW infants with adverse neurologic outcomes illustrates the broad spectrum of possible mechanisms that might be involved. Dexamethasone dosing has not been guided by pharmacokinetic study, so the concentrations may have accumulated to 'toxic levels.'…”
mentioning
confidence: 99%