Alterations in the Metabolism of Glycosaminoglycans and Collagen

Kochhar, D. M.; Larsson, K

doi:10.1007/978-1-4615-8933-4_10

Cited by 8 publications

(1 citation statement)

References 145 publications

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“…These investigations complement the recent work by Solursh & Morriss (1977; see also, Morriss & Solursh, 1978) who have stressed the part played by the underlying mesenchyme cells and the biochemical components of the intercellular matrix during the process of neurulation (for observations on the role of extracellular components during morphogenesis, see Kochhar & Larsson, 1977).…”

Section: Neural Tube Defectssupporting

confidence: 69%

The role of embryology in teratological research, with particular reference to the development of the neural tube and heart

Kaufman¹

1981

Reproduction

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Section: Neural Tube Defectssupporting

confidence: 69%

The role of embryology in teratological research, with particular reference to the development of the neural tube and heart

Kaufman¹

1981

Reproduction

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Changes in chemical composition of chick embryos treated with a β‐xyloside and a lathyrogen

1979

Teratology

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Nine-day chick embryos were treated with 4-methylumbelliferyl beta-D-xyloside or beta-aminopropionitrile fumarate, and their gross chemical composition was examined one week later. Total DNA was 10--20% less in embryos treated with either drug than it was in control embryos. Xyloside-treated embryos showed marked increases in percent wet weight and in sodium/DNA and chloride/DNA ratios, and small decreases in protein/DNA, hydroxyproline/DNA and sulfate/DNA. None of these parameters was affected in embryos treated with beta-aminopropionitrile. Approximately 85% of the uronic acid of control embryos was present as chondroitin sulfate, with a degree of sulfation of 80% and charge density of 1.8; all of this chondroitin sulfate was covalently linked to peptide and had a number-average molecular weight of 29,300. In embryos treated with beta-xyloside, 90% of the uronic acid was present as chondroitin sulfate, with a degree of sulfation of 40% and charge density ranging from 1 to 2; 27% of this chondroitin sulfate, with an average molecular weight of 25,400, was peptide linked, while 73% was linked to 4-methylumbelliferone and had an average molecular weight of 22,900. The chemical differences between embryos treated with the xyloside and embryos treated with the lathyrogen reinforce the conclusion on morphological grounds that these are distinct syndromes involving different aspects of the extracellular matrix.

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Interference with steps in collagen synthesis as a biochemical mechanism of teratogenesis

Bhatnagar¹,

Rapaka²

1979

Abnormal Embryogenesis

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Alterations in the Metabolism of Glycosaminoglycans and Collagen

Cited by 8 publications

References 145 publications

The role of embryology in teratological research, with particular reference to the development of the neural tube and heart

The role of embryology in teratological research, with particular reference to the development of the neural tube and heart

Changes in chemical composition of chick embryos treated with a β‐xyloside and a lathyrogen

Interference with steps in collagen synthesis as a biochemical mechanism of teratogenesis

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