Alterations in the periodontium after ovariectomy in rats: the effects of a Japanese herbal medicine, Chujo‐to

Hidaka, Sumitomo; Okamoto, Yoshizo; Yamada, Yuji; Miyazaki, Kôji; Kimura, Takayoshi

doi:10.1002/1099-1573(200011)14:7<527::aid-ptr662>3.0.co;2-#

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…A single human trial has reported higher alveolar bone density with ERT [ 24 ], yet with the ovariectomized rat model it is clear that estrogen treatment can preserve both the periodontium [ 54 , 55 ] and alveolar bone density [ 56 , 57 ] and also reduce mandibular bone turnover [ 58 ] ( Table 3 ). Rats that were ovariectomized at an unreported age and maintained for 2 weeks were divided into sham, OVX, and OVX + estrogen and were implanted with mini osmotic pumps to continuously deliver either vehicle (sham and OVX groups) or estrogen (OVX + estrogen group) [ 54 ].…”

Section: Estrogen Replacement Therapy Preserves Mandibular Health mentioning

confidence: 99%

“…Another study indicates that rats that were ovariectomized at 13 weeks of age were administered 17 β -estradiol by injection at a dose of 10 μ g/kg for 5 days/week, for 7 weeks after ovariectomy [ 55 ]. To measure the periodontal ligament space, left hemimandibles were cut sagittally at the buccal/lingual midpoint ( Figure 5 ) to expose M1–M3 and were scanned via scanning electron microscopy.…”

Section: Estrogen Replacement Therapy Preserves Mandibular Health mentioning

confidence: 99%

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The Ovariectomized Rat as a Model for Studying Alveolar Bone Loss in Postmenopausal Women

Johnston

Ward

2015

BioMed Research International

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In postmenopausal women, reduced bone mineral density at the hip and spine is associated with an increased risk of tooth loss, possibly due to a loss of alveolar bone. In turn, having fewer natural teeth may lead to compromised food choices resulting in a poor diet that can contribute to chronic disease risk. The tight link between alveolar bone preservation, tooth retention, better nutritional status, and reduced risk of developing a chronic disease begins with the mitigation of postmenopausal bone loss. The ovariectomized rat, a widely used preclinical model for studying postmenopausal bone loss that mimics deterioration of bone tissue in the hip and spine, can also be used to study mineral and structural changes in alveolar bone to develop drug and/or dietary strategies aimed at tooth retention. This review discusses key findings from studies investigating mandible health and alveolar bone in the ovariectomized rat model. Considerations to maximize the benefits of this model are also included. These include the measurement techniques used, the age at ovariectomy, the duration that a rat is studied after ovariectomy and habitual diet consumed.

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Section: Estrogen Replacement Therapy Preserves Mandibular Health mentioning

confidence: 99%

Section: Estrogen Replacement Therapy Preserves Mandibular Health mentioning

confidence: 99%

The Ovariectomized Rat as a Model for Studying Alveolar Bone Loss in Postmenopausal Women

Johnston

Ward

2015

BioMed Research International

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“…As exogenous administration of any pharmacologic active ingredient may threaten the balanced physiologic and cellular responses to different periodontal treatments, the use of caffeine by patients may result in cellular and molecular changes leading to a decrease in treatment efficacy. Although caffeine is consumed largely in different parts of the world in the form of drinks and as an adjunct to nonsteroidal anti‐inflammatory drugs, no in vitro studies have been conducted on the effects of caffeine on human fibroblast cells, a unique connective tissue cell line and potential seed cell for bone and periodontal regeneration.…”

Section: Introductionmentioning

confidence: 99%

Caffeine alters mitochondrial dehydrogenase and alkaline phosphatase activity of human gingival fibroblasts in vitro

Bozchaloei

Gong

Dehpour

et al. 2012

J of Invest & Clin Dent

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“…Kampo medicines have less side effects, and therefore, seem to be more suitable for a long-term medication. We reported their inhibitory effects on both the progression of tibial bone loss and the alteration of periodontium induced by ovariectomy in rats ( 12 – 15 ).…”

Section: Introductionmentioning

confidence: 99%

Royal Jelly Prevents Osteoporosis in Rats: Beneficial Effects in Ovariectomy Model and in Bone Tissue Culture Model

Hidaka

Okamoto

Uchiyama

et al. 2006

Evidence-Based Complementary and Alternative Medicine

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Royal jelly (RJ) has been used worldwide for many years as medical products, health foods and cosmetics. Since RJ contains testosterone and has steroid hormone-type activities, we hypothesized that it may have beneficial effects on osteoporosis. We used both an ovariectomized rat model and a tissue culture model. Rats were divided into eight groups as follows: sham-operated (Sham), ovariectomized (OVX), OVX given 0.5% (w/w) raw RJ, OVX given 2.0% (w/w) RJ, OVX given 0.5% (w/w) protease-treated RJ (pRJ), OVX given 2.0% (w/w) pRJ, OVX given 17β-estradiol and OVX given its vehicle, respectively. The Ovariectomy decreased tibial bone mineral density (BMD) by 24%. Administration of 17β-estradiol to OVX rats recovered the tibial BMD decrease by 100%. Administration of 2.0% (w/w) RJ and 0.5–2.0% (w/w) pRJ to OVX rats recovered it by 85% or more. These results indicate that both RJ and pRJ are almost as effective as 17β-estradiol in preventing the development of bone loss induced by ovariectomy in rats. In tissue culture models, both RJ and pRJ increased calcium contents in femoral-diaphyseal and femoral-metaphyseal tissue cultures obtained from normal male rats. However, in a mouse marrow culture model, they neither inhibited the parathyroid hormone (PTH)-induced calcium loss nor affected the formation of osteoclast-like cells induced by PTH in mouse marrow culture system. Therefore, our results suggest that both RJ and pRJ may prevent osteoporosis by enhancing intestinal calcium absorption, but not by directly antagonizing the action of PTH.

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Alterations in the periodontium after ovariectomy in rats: the effects of a Japanese herbal medicine, Chujo‐to

Cited by 11 publications

References 27 publications

The Ovariectomized Rat as a Model for Studying Alveolar Bone Loss in Postmenopausal Women

The Ovariectomized Rat as a Model for Studying Alveolar Bone Loss in Postmenopausal Women

Caffeine alters mitochondrial dehydrogenase and alkaline phosphatase activity of human gingival fibroblasts in vitro

Royal Jelly Prevents Osteoporosis in Rats: Beneficial Effects in Ovariectomy Model and in Bone Tissue Culture Model

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