Alterations in the Porcine Colon Microbiota Induced by the Gastrointestinal Nematode Trichuris suis

Li, Robert W.; Wu, Sitao; Li, Weizhong; Navarro, Karl; Couch, Robin D.; Hill, Dolores E.; Urban, Joseph F.

doi:10.1128/iai.00141-12

Cited by 190 publications

(243 citation statements)

References 49 publications

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“…The diversity indices of bacterial 16S rDNA and the change in soil bacterial community composition increased under intensive grazing [62]. A growing body of evidence shows that parasitic infections are associated with the alterations of porcine proximal colon microbiota at 21-days of infection with Trichuris suis [63], and the changes in the caprine abomasal microbial composition induced by H. contortus at 50-days infection [64]. Interactions among helminth parasites, bacterial microbiota, and host immunity have been reviewed in detail elsewhere [65; 66; 67] (Fig.…”

Section: Factors Affecting Gastrointestinal Tract (Git) Microbiota:-mentioning

confidence: 99%

Next Generation Sequencing and Microbial Community Associated With Eukaryotes Including Parasitic Heliminths: A Review Article.

Ashram¹,

Nasr²,

Mehmood³

et al. 2017

IJAR

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Section: Factors Affecting Gastrointestinal Tract (Git) Microbiota:-mentioning

confidence: 99%

Next Generation Sequencing and Microbial Community Associated With Eukaryotes Including Parasitic Heliminths: A Review Article.

Ashram¹,

Nasr²,

Mehmood³

et al. 2017

IJAR

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“…Metabolism of dietary carbohydrates is regulated by the intestinal microorganisms mainly in the hindguts of monogastric animals like pigs and humans [40]. The fermentation products like butyrate and acetates are absorbed by the intestinal epithelium acting as an energy-source and also serve to improve local epithelial cell function [40]. In pigs fed with fermentable carbohydrates, the SCFA concentration is greater in the large intestine with a reduction the luminal pH value which affects the intestinal microbial population [40].…”

Section: Shift In the Metabolome In The Animal Gut Due To The Presencmentioning

confidence: 99%

“…The morphology and mucin biosynthesis of the host large intestine is reportedly influenced by both helminths infections and dietary carbohydrates [41]. Metabolism of dietary carbohydrates is regulated by the intestinal microorganisms mainly in the hindguts of monogastric animals like pigs and humans [40]. The fermentation products like butyrate and acetates are absorbed by the intestinal epithelium acting as an energy-source and also serve to improve local epithelial cell function [40].…”

Section: Shift In the Metabolome In The Animal Gut Due To The Presencmentioning

confidence: 99%

“…There are evidences that the metabolic activities are shifted in favour of both the helminth and the bacteria so that they may co-exist peacefully in the host gut. Li et al [40] hypothesized that the mucosal injury caused by Trichuris suis in the gut of pigs led to an increase of microbial population like the Mucispirillum bacteria having strong predilections for the mucosal surfaces. This could cause increased mucous production which instead of eliminating the worms from the host gut could actually be protecting the helminths from the gastric juices and/or other strong proteolytic secretions in the host gut.…”

Section: Shift In the Metabolome In The Animal Gut Due To The Presencmentioning

confidence: 99%

“…The fermentation products like butyrate and acetates are absorbed by the intestinal epithelium acting as an energy-source and also serve to improve local epithelial cell function [40]. In pigs fed with fermentable carbohydrates, the SCFA concentration is greater in the large intestine with a reduction the luminal pH value which affects the intestinal microbial population [40]. Li et al [40] in their experiments demonstrated that the number of open reading frames (ORFs) identified for carbohydrate metabolism processes were significantly reduced in T. suis infections [40].…”

Section: Shift In the Metabolome In The Animal Gut Due To The Presencmentioning

confidence: 99%

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Helminth Infections and Gut Microbiota: The Futuristic Study of Pathogen Virulence and Gut Ecosystem

Biswal¹

2016

J Mol Biomark Diagn

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The animal gut has co-evolved with the microbes and parasites leading to an increased tolerance to their existence therein. Their peaceful co-existence has been a subject of research in the recent years to decipher their probabilities in multidimensional applications ranging from eradicating the helminths without affecting gut homeostasis or using helminths as therapeutics. Negligence in any one of the components of the animal gut can lead to unhealthy gut ecosystems often manifesting a diseased state. Supply of key nutrients, synthesis of vitamins, resistance to invasion by pathogens and helping in hatching of helminth eggs are some important services provided by the gut bacteria that may well be utilised by the helminth. The gut bacteria thus seem to be exploited by the helminths for establishment of infection in the host. However, relationships are not as simple as it seems. The paper tries to present different aspects of this host-bacteria-helminth relationship and their future perspectives.

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The relationship between pinworm (Trypanoxyuris) infection and gut bacteria in wild black howler monkeys (Alouatta pigra)

Martínez-Mota

Righini

Mallott

et al. 2021

American J Primatol

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Gut bacteria may coexist with other groups of organisms, such as nematode parasites, that inhabit the gastrointestinal tract of primates; however, the possible effects of endoparasites on bacterial communities are frequently overlooked. Here we explored whether infection with Trypanoxyuris, an oxyurid gastrointestinal parasite, is associated with changes in the gut bacterial community of wild black howler monkeys (Alouatta pigra), by comparing gut bacterial communities of consistently infected individuals and individuals that never tested positive for Trypanoxyuris throughout different months across the year. We additionally controlled for other sources of variation reported to influence the primate microbiome including individual identity, social group, and seasonality. Trypanoxyuris infection was not related to differences in gut bacterial alpha diversity, but was weakly associated with differences in gut bacterial community structure. In contrast, among the covariates considered, both individual identity and social group were more strongly associated with variation in the howler gut bacterial community. Our results suggest that gastrointestinal parasites may be associated, to some extent, with shifts in the gut bacterial communities hosted by free-ranging primates, although a causal link still needs to be established. Further studies of wild primate hosts infected with parasite species with different pathogenicity are needed to better elucidate health-related consequences from the parasite-microbiome interplay.

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Alterations in the Porcine Colon Microbiota Induced by the Gastrointestinal Nematode Trichuris suis

Cited by 190 publications

References 49 publications

Next Generation Sequencing and Microbial Community Associated With Eukaryotes Including Parasitic Heliminths: A Review Article.

Next Generation Sequencing and Microbial Community Associated With Eukaryotes Including Parasitic Heliminths: A Review Article.

Helminth Infections and Gut Microbiota: The Futuristic Study of Pathogen Virulence and Gut Ecosystem

The relationship between pinworm (Trypanoxyuris) infection and gut bacteria in wild black howler monkeys (Alouatta pigra)

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