Helminth Infections and Gut Microbiota: The Futuristic Study of Pathogen Virulence and Gut Ecosystem

Biswal, Debraj

doi:10.4172/2155-9929.1000283

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…The latter information is consistent with our findings, as the Mucispirillum was 20 times more abundant in mucosal versus luminal proximal colon samples. Mucispirillum members were already detected in an increased amount in helminth infected pigs [46,47] but also in post-weaning piglet feces [11,13]. The Acinetobacter genus was also identified in a higher relative abundance in mucosal samples.…”

Section: Discussionmentioning

confidence: 99%

Microbiota Composition and Functional Profiling Throughout the Gastrointestinal Tract of Commercial Weaning Piglets

et al. 2019

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Dietary, environmental, and social stresses induced by weaning transition in pig production are associated with alterations of gut microbiota, diarrhea, and enteric infections. With the boom of -omic technologies, numerous studies have investigated the dynamics of fecal bacterial communities of piglets throughout weaning but much less research has been focused on the composition and functional properties of microbial communities inhabiting other gastrointestinal segments. The objective of the present study was to bring additional information about the piglet bacterial and archaeal microbiota throughout the entire digestive tract, both at the structural level by using quantitative PCR and high-throughput sequencing, and on functionality by measurement of short-chain fatty acids and predictions using Tax4Fun tool. Our results highlighted strong structural and functional differences between microbial communities inhabiting the fore and the lower gut as well as a quantitatively important archaeal community in the hindgut. The presence of opportunistic pathogens was also noticed throughout the entire digestive tract and could trigger infection emergence. Understanding the role of the intestinal piglet microbiota at weaning could provide further information about the etiology of post-weaning infections and lead to the development of effective preventive solutions.

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Section: Discussionmentioning

confidence: 99%

Microbiota Composition and Functional Profiling Throughout the Gastrointestinal Tract of Commercial Weaning Piglets

et al. 2019

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“…Gut helminthes may secrete a verity of products for modulation of microbial growth in the gut or they may compete with gut microbes for nutrients. In either case, gut helminthes leave their impact on the host [49].…”

Section: Impact Of Parasites On Gut Ecologymentioning

confidence: 99%

Impact of parasitic infection on human gut ecology and immune regulations

Ahsan

Abdullah

2021

transl med commun

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The human body harbors trillions of microbes collectively known as microbiota. The human gut microbiota is importantly involved in most of the human metabolic and regulatory pathways. The gut microbiota needs to be balanced for the health of the host. Several factors are involved in the distribution of microbiota in the human body, in most cases these microbiotas are commensals, but some circumstances lead to serious disorders and the development of infections from microbiota. When parasites colonize the gut, the balance between the host and the gut microbiota can be disturbed. Parasitic invasion in the gut is associated with unhygienic conditions including contaminated food and water. Parasitic invasion in the gut induces the immune response to recognize and eliminate pathogens. The current study highlights the immune system’s response to disruption of normal intestinal microbiota and parasitic infections.

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The therapeutic prospect of crosstalk between prokaryotic and eukaryotic organisms in the human gut

Mubaraki

Ahmad

Hafiz

et al. 2018

FEMS Microbiology Ecology

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The peaceful phenomenon of the co-evolution between the prokaryotes (microbiota) and the eukaryotes (parasites including protozoa and helminths) in the animal gut has drawn the researchers' attention. Importantly, exploring the potential of helminths for therapeutic uses was one of the reasons behind understanding the physiological and immunological crosstalk existing between them. Here we discuss the interactive immunological associations of helminths and microbial responses individually and in combination with their hosts. Considering that there is probably crosstalk between eukaryotic organisms like helminths and protozoa with their host's gut microbiota, in this review we searched the literature identifying the privileged and favourable relationship generated between them in the host. Understanding the possibilities of the role of helminths along with gut microbiota as a black box would certainly help decode the therapeutic intrusion with helminths in experimental clinical trials, and a successful trial could be used to consider possible future and safe treatments for various immune-inflammatory diseases in humans.

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Helminth Infections and Gut Microbiota: The Futuristic Study of Pathogen Virulence and Gut Ecosystem

Cited by 3 publications

References 56 publications

Microbiota Composition and Functional Profiling Throughout the Gastrointestinal Tract of Commercial Weaning Piglets

Microbiota Composition and Functional Profiling Throughout the Gastrointestinal Tract of Commercial Weaning Piglets

Impact of parasitic infection on human gut ecology and immune regulations

The therapeutic prospect of crosstalk between prokaryotic and eukaryotic organisms in the human gut

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