Alterations in the rate of lipogenesis <i>in vivo</i> in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin

Agius, Loranne; Robinson, Alison; Girard, Jean; Williamson, Dermot H.

doi:10.1042/bj1800689

Cited by 97 publications

(76 citation statements)

References 17 publications

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“…One possibility is that the lactating gland acts as a 'sink' for insulin, in that the tissue is likely to contain a large number of insulin receptors and the hormone is delivered to the gland at a fast rate due to the high blood flow..Recent experiments with thelectomized glands (removal of teats) have indicated the importance of the rate of delivery of hormones, rather than the blood concentrations, in the regulation of tissue receptor levels for prolactin and oestrogen [73]. Further support for the postulate that the lactating gland is a major site of insulin (and glucose) uptake is the finding that on removal of the pups (24 h) when the blood flow to the gland is halved [74] the blood glucose increases by 0.6 mmol/l and the plasma insulin rises 3-fold [61]. The decrease in plasma insulin on starvation and the rapid increase on refeeding [IO] are in agreement with the postulated role of insulin as a signal of carbohydrate availability to the gland.…”

Section: Insulinmentioning

confidence: 58%

“…In liver the rate of lipogenesis in vitro is higher than in the non-lactating rat [ 19,891 but the rate in vivo is not increased, suggesting that a systemic factor may depress hepatic lipogenesis in vivo. If pups are removed from the mother for 24 h lipogenesis increases 4-fold in maternal adipose tissue and doubles in liver and these increases can be prevented by administration of prolactin [61]. Treatment of lactating rats in the presence of the pups with bromocryptine (24 h) increases lipogenesis in both adipose tissue and liver and again this does not occur of prolactin is administered simultaneously [61].…”

Section: Lipogenesismentioning

confidence: 94%

“…If pups are removed from the mother for 24 h lipogenesis increases 4-fold in maternal adipose tissue and doubles in liver and these increases can be prevented by administration of prolactin [61]. Treatment of lactating rats in the presence of the pups with bromocryptine (24 h) increases lipogenesis in both adipose tissue and liver and again this does not occur of prolactin is administered simultaneously [61]. Removal of pups for 48 h increases the number of insulin receptors on parametrial adipose tissue and the rate of fatty acid synthesis in vitro [90]; these changes cannot be reversed by prolactin which indicates that the hormone's effects may be transient.…”

Section: Lipogenesismentioning

confidence: 99%

“…There is ample evidence in vitro [5,1 l] and in vivo [9,61] that the rate of lipogenesis in adipose tissue is decreased during lactation. In liver the rate of lipogenesis in vitro is higher than in the non-lactating rat [ 19,891 but the rate in vivo is not increased, suggesting that a systemic factor may depress hepatic lipogenesis in vivo.…”

Section: Lipogenesismentioning

confidence: 99%

“…Prolactin deficiency (24 h) does not affect the removal of glucose by the gland as measured by arteriovenous difference measurements [45], but it decreases the rate of lipogenesis in vivo by about 40% [61]. In acini isolated from prolactin-deficient lactating rats the utilization of glucose is slightly decreased (20%) as is lipogenesis and a high proportion of the glucose removed accumulates as lactate and pyruvate [45].…”

Section: Effects Of Prolactin Deficiencymentioning

confidence: 99%

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Integration of metabolism in tissues of the lactating rat

1980

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Section: Insulinmentioning

confidence: 58%

Section: Lipogenesismentioning

confidence: 94%

Section: Lipogenesismentioning

confidence: 99%

Section: Lipogenesismentioning

confidence: 99%

Section: Effects Of Prolactin Deficiencymentioning

confidence: 99%

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Integration of metabolism in tissues of the lactating rat

1980

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Mammary tissue proteomics in a pig model indicates that dietary valine supplementation increases milk fat content via increased de novo synthesis of fatty acid

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Are the short‐photoperiod‐induced decreases in serum prolactin responsible for the seasonal changes in energy balance in Syrian and Siberian hamsters?

Bartness¹,

Wade

Goldman³

1987

J. Exp. Zool.

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Serum prolactin (PRL) decreases in Syrian (Mesocricetus auratus) and Siberian (Phodopus sungorus sungorus) hamsters following short-photoperiod exposure. Both species also exhibit short-photoperiod-induced changes in body and lipid mass, but in opposite directions; Syrian hamsters increase and Siberian hamsters decrease their body weight, changes reflected nearly exclusively in their carcass lipid content. The purpose of these experiments was to determine whether the photoperiod-induced changes in PRL were responsible for the seasonal changes in energy balance in Syrian and Siberian hamsters by using the strategy of experimentally producing serum PRL levels opposite to those normally associated with the photoperiod in which the animals were housed. In long photoperiods serum PRL was reduced to short-day levels by subcutaneous (s.c.) CB-154 (bromoergocryptine, a dopamine agonist) injections. In short photoperiods, serum PRL was elevated to long-day levels in Syrian hamsters by ectopic pituitary explants, and in Siberian hamsters, serum PRL was elevated by chronic s.c. infusions of ovine PRL (oPRL). In both species, manipulations of serum PRL did not affect food intake, carcass composition, or the wet weight of various white and brown adipose tissue pads (WAT and BAT, respectively). Body weight increased in CB-154-treated Syrian hamsters and decreased in Siberian hamsters, an effect partially reversed by coadministration of oPRL in Syrian, but not Siberian, hamsters. Thus, lowering serum PRL to short-day levels in long-day-housed hamsters of both species mimicked the directional change in body weight appropriate for each species when they are exposed to short days. This effect of CB-154 on body weight may be a result of some as yet unidentified effect of dopaminergic stimulation on overall growth since 1) these changes in body weight were not reflected as changes in lipid mass, as occurs naturally following short-day exposure for each species, and 2) neither species exhibited a reciprocal change in body weight when serum PRL was experimentally elevated in short days. Alternatively, it may be that once the energetic responses to short-day exposure have been fully expressed, the ability of PRL to stimulate the target sites of action for PRL for these responses may be decreased. BAT protein content, cytochrome oxidase activity (measures of metabolic growth of this tissue), and retroperitoneal total and specific lipoprotein lipase (LPL) activities were increased by CB-154 treatment in Syrian hamsters.(ABSTRACT TRUNCATED AT 400 WORDS)

show abstract

Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin

Cited by 97 publications

References 17 publications

Integration of metabolism in tissues of the lactating rat

Integration of metabolism in tissues of the lactating rat

Mammary tissue proteomics in a pig model indicates that dietary valine supplementation increases milk fat content via increased de novo synthesis of fatty acid

Are the short‐photoperiod‐induced decreases in serum prolactin responsible for the seasonal changes in energy balance in Syrian and Siberian hamsters?

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