Alterations of acute phase reaction and cytokine production in patients following severe burn injury

Dehne, M. G.; Sablotzki, Armin; Hoffmann, Andreas; Mühling, J.; Dietrich, Friedrich E; Hempelmann, G.

doi:10.1016/s0305-4179(02)00050-5

Cited by 109 publications

(56 citation statements)

References 24 publications

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“…[1,6,7] Yanık olgularında başta enfeksiyon olmak üzere komplikasyonların en iyi göstergesinin ne olacağını saptamaya yönelik ça-lışmalar; eritrosit sedimentasyon hızı, [7] C-reaktif protein, [5] prokalsitonin, [1,8] C-3 kompleman, alfa 2-makroglobulin, haptoglobulin, alfa 1-asit glikoprotein, pre-albümin, transferrin, retinol bağlayıcı protein, apolipoprotein A1-B, serbest yağ asitleri ve trigliserid [9] gibi biyokimyasal belirteçler üzerine yoğunlaşır. Bununla beraber yanık hastalarında komplikasyon belirteci olabilecek histopatolojik morfolojik değişiklik-leri konu alan çalışmalar son derece azdır.…”

Section: Resultsunclassified

“…[12] Bunun yanın-da, lökopeninin sepsisi ekarte edememesinin ötesinde, sistemik enflamatuvar cevap sendromu ölçütleri arasında gösterilmesi, klinikte beyaz küre sayısının öne-mini azaltmıştır. [1,5,6] Bu nedenlerle, yanığın en önem-li morbidite ve mortalite nedeni olan enfeksiyon kriterleri arasında beyaz küre sayısının önemi sınırlıdır. [1] Çalışmamızda benzer şekilde beyaz küre sayısı ile komplikasyon ya da morbidite arasında ilişkinin bulunmaması sürpriz olmamıştır.…”

Section: Discussionunclassified

See 1 more Smart Citation

The Association Between Cellular Morphological Changes in Peripheral Blood Smear and Complications in Pediatric Burn Cases

Bozkurt¹,

Kuvat²,

Kapi³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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AMAÇYanık olgularında mortalite ve morbidite erken tanı ile azaltılabilir. Sepsis gibi yanık komplikasyonlarının erken tanısı için çok sayıda belirteç kullanılır. Bu çalışmada, yanık olgularında sayısal/morfolojik granülosit anormallikleri ve komplikasyonlar arasındaki ilişki araştırıldı. Bu sayede, yanık ilintili komplikasyonlar için histopatolojik belirteç/lerin ortaya konulması amaçlandı. GEREÇ VE YÖNTEMKasım 2006 ve Kasım 2009 yılları arasında hastanede yatı-rılan 32 pediatrik yanık olgusu çalışmaya dahil edildi. Toplam 192 tam kan sayımı ve periferal kan yayması sonuçla-rı karşılıklı analiz edildi. Bulgular, beyaz kan hücresi sayı-mı, periferal kan yayması değişiklikleri (immatür granüler hücreler, toksik granülasyon, granül ve Döhle cisimciklerinin görünümü) ve bakteriyemi, sepsis, yara enfeksiyonu, ileri anemi ve greft kaybı gibi komplikasyonlar arasındaki olası korelasyonun saptanmasında kullanıldı. BULGULARBeyaz kan hücresi sayısındaki değişiklikler ve immatür granüler hücrelerin görülmesinin komplikasyonlar için tanısal belirteç olarak kullanımı uygun değildir. Bununla beraber, toksik granülasyon, granül ve Döhle cisimciği görülmesi ile komplikasyonla karşılaşılması arasında istatistiksel olarak anlamlı korelasyon bulunmaktaydı (p: 0,0001<, 0,041, 0,001). SONUÇToksik granülasyon, granül ve Döhle cisimciğinin, yanık ilintili komplikasyonların tahmininde yardımcı olabileceği görünmektedir. Bundan dolayı, periferik kan yaymaları gelecek komplikasyonların tahmininde uygun tetkiklerdir.

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Section: Resultsunclassified

Section: Discussionunclassified

The Association Between Cellular Morphological Changes in Peripheral Blood Smear and Complications in Pediatric Burn Cases

Bozkurt¹,

Kuvat²,

Kapi³

et al. 2011

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

“…Seven days after admission (M 1 ), these values had significantly elevated, as verified by several authors. Augmented serum TNF-α levels were observed in burn patients, as well as in patients with septic shock (4,(18)(19)(20). Previous studies also…”

Section: Introductionmentioning

confidence: 83%

“…showed considerable elevations in TNF-α levels associated with sepsis and unfavorable prognosis in burn patients (4,(18)(19)(20). To the best of our knowledge, there are no works in the literature comparing immune alterations and nutritional status.…”

Section: Introductionmentioning

confidence: 99%

Nutritional, immunological and microbiological profiles of burn patients

Barbosa¹,

Calvi²,

Pereira³

2009

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:A burn is a lesion on an organic tissue resultant from direct or indirect action of heat on the organism. The present study aimed to evaluate the nutritional, immunological and microbiological status of burn patients at the Bauru State Hospital, São Paulo state, Brazil, in 2007. Eight patients, aged more than 18 years and injured up to 24 hours, were evaluated at the moment of hospitalization and seven days later. All victims were males with a mean age of 38 years. On average, 17.5% of their body surfaces were burned and 50% of the patients were eutrophic. There were significant alterations in levels of erythrocytes, hemoglobin, hematocrit, total protein and albumin due to increased endothelial permeability, direct destruction of proteins in the heat-affected area and blood loss from lesions or debridement. At a second moment, cytokines IL-6 and TNF-α had augmented significantly, with IL-6 presenting elevated levels in relation to controls at the first moment. Microbiological analysis showed that 100% of the samples collected at hospital admission were negative and after one week Staphylococcus aureus was found in all cultures. Therefore, a burn patient may be considered immunosuppressed and these results indicate significant nutritional, immunological and microbiological alterations that can interfere in his recovery.

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“…Interestingly, haptoglobin did not inhibit IL-6 during this period. We presume that the haptoglobin concentration in the blood stream was not sufficient enough to inhibit IL-6 because it is known to be produced by various cells and keeps increasing for the first five days in severe burn patients 25,26 .…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin Reduces Inflammatory Cytokine INF-γ and Facilitates Clot Formation in Acute Severe Burn Rat Model

et al. 2017

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Haptoglobin exerts renal protective function by scavenging free hemoglobin from the urine and blood stream in patients with hemolytic disorders. Recent studies elucidate the relationships between haptoglobin and inflammation. In addition, coagulopathy is often induced by systemic inflammation characterized by the presence of vascular endothelial damage. We hypothesize that haptoglobin might have an anti-inflammatory effect and affect hypercoagulability using rat burn model. Thirty anesthetized rats of six-weeks of age received over 30% full-thickness scald burn on the dorsal skin surface. All rats were injected with either haptoglobin (Hpt) or normal saline (NS) intraperitoneally. The rats were divided into three groups: 1) control group (NS 20 mL/kg); 2) low concentration of Hpt group, L-Hpt, (Hpt 4 mL (80 U)/kg+NS 16 mL/kg); and 3) high concentration of Hpt group, H-Hpt, (Hpt 20 mL (400 U)/kg).While under anesthesia, all rats were euthanized by exsanguination at 6 hours (N=5) and 24 hours (N= 5). Inflammatory and anti-inflammatory cytokines were measured and whole-blood viscoelastic tests were performed by thromboelastometry (ROTEM). Haptoglobin significantly reduced free hemoglobin 24 hours after the injury. Improvement of hematuria was confirmed in the H-Hpt group. There were no differences in thrombin-antithrombin complex and plasmin-α2 plasmin inhibitor complex. The haptoglobin tended to decrease interferon-gamma (IFN-γ) in H-Hpt group. ROTEM findings of the L-Hpt group showed significantly higher clot firmness and shorter time to maximum clot formation velocity than the control group. Haptoglobin reduced INF-γ, and accelerated speed of clot formation in acute phase of severe burn. (J Nippon Med Sch 2017; 84: 64 72)

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Alterations of acute phase reaction and cytokine production in patients following severe burn injury

Cited by 109 publications

References 24 publications

The Association Between Cellular Morphological Changes in Peripheral Blood Smear and Complications in Pediatric Burn Cases

The Association Between Cellular Morphological Changes in Peripheral Blood Smear and Complications in Pediatric Burn Cases

Nutritional, immunological and microbiological profiles of burn patients

Haptoglobin Reduces Inflammatory Cytokine INF-γ and Facilitates Clot Formation in Acute Severe Burn Rat Model

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