Haptoglobin Reduces Inflammatory Cytokine INF-γ and Facilitates Clot Formation in Acute Severe Burn Rat Model

Koami, Hiroyuki; Sakamoto, Yuichiro; Miyasho, Taku; Noguchi, Ryo; Sato, Norio; Kai, Keita; Yamada, Kosuke; Inoue, Satoshi

doi:10.1272/jnms.84.64

Cited by 6 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…only mention ‘boiling water’, which is relative, for the boiling point of water depends on the altitude of the environment. Three studies 13 , 24 , 26 did not inform the temperature and the length of exposure time to water; therefore, they are not reproducible. As already mentioned above, in order to determine the depth of the injury, it is necessary to associate the water temperature with the length of exposure time of the animal´s skin to it.…”

Section: Discussionmentioning

confidence: 99%

“…The location and size of the injury depend on the objective of the study, but it is essential to accurately describe the location and the formula used to obtain the size of the injury in order to reproduce the model. No study included in this review described precisely how the location of the injury was obtained as did Walker and Mason 6 , only described as dorsal, without providing details of where on the dorsal area 14 , 16 – 22 , 24 . Bortolin et al 14 .…”

Section: Discussionmentioning

confidence: 99%

“…In reading the articles in full, we noticed changes in temperature, location and injury extent. We also read studies that confirm having made changes to the model, but do not mention what kind of changes were made 15 – 18 , 21 , 24 – 26 , thus making it impossible to reproduce the model.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Experimental models of scald burns. A scope review

et al. 2019

View full text Add to dashboard Cite

Purpose:To conduct a scope review of the experimental model described by Walker and Mason, by identifying and analyzing the details of the method.Methods:The authors searched Pubmed-Medline, Cochrane-Bireme and PEDro databases for articles published between January 2016 and December 2018, using the following search queries: burns, burn injuries, models animal, and animal experimentation. All articles whose authors used Walker and Mason's model - with or without changes to the method in Wistar rats - were included in this study.Results:The search identified 45 mentions of Walker and Mason's model; however, after reading each summary, 20 were excluded (of which 5 due to duplicity). The inconsistencies observed after the scope review were: water temperature, length of time of exposure of the experimental model's skin to water, extent of the burnt area, and the description of the thickness/depth of the injury.Conclusions:Reproducibility of a scientific method is the basis to prove the veracity of the observed results. Thus, it is necessary to have a greater number of publications that adopt a reproducible scientific method, for this review found inconsistencies in the description of Walker and Mason's model.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Experimental models of scald burns. A scope review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Rotational thromboelastometry (ROTEM delta; Tem International GmbH, Munich, Germany) is a point-of-care test used to evaluate blood viscosity 11…”

Section: Rotational Thromboelastometrymentioning

confidence: 99%

Effect of Tranexamic Acid for Traumatic Brain Injury: A Case Report

2020

Self Cite

View full text Add to dashboard Cite

Traumatic brain injury (TBI) often results in coagulopathy, which increases mortality risk. The Clinical Randomization of an Antifibrinolytic in Significant Head injury (CRASH)-2 and CRASH-3 trials confirmed that tranexamic acid (TXA) was effective after trauma. Herein, we report a unique coagulation change in a patient with TBI given TXA after point-of-care assessment. Coagulation functions were impaired on admission. At 1 hour after TXA administration, clotting time was further prolonged in the extrinsic coagulation pathway but shortened in the intrinsic coagulation system. The results of a test of the total thrombus-formation analysis system showed improved blood clot formation ability. Intrinsic coagulation and clot formation improved after TXA administration in a TBI patient with coagulopathy.

show abstract

“…Plasma-purified haptoglobin (Japan Blood Products Organization, Tokyo, Japan) has been approved for clinical use in Japan since 1985 for hemoglobinuria following profound hemolysis in severe burns, cardiovascular surgery with extracorporeal circulation usage, or massive transfusion provision [8,[11][12][13][14][15]. The rationale for the provision of haptoglobin is based on the concept that they act by scavenging circulating-free hemoglobin [10, [16][17][18][19]. However, haptoglobin provision in patients with burns has been described only in a few case reports [14,20,21] and one small case-series (n = 10) from Japan [11].…”

mentioning

confidence: 99%

Haptoglobin use and acute kidney injury requiring renal replacement therapy among patients with severe burn injury: a nationwide database study

et al. 2019

View full text Add to dashboard Cite

a BStra ct BackgrOundPrevious studies have suggested that haptoglobin may be beneficial for preventing acute kidney injury (AKI) after severe burns. Although haptoglobin has been approved for the treatment of haemoglobinuria and subsequent AKI in Japan, robust evidence for this is lacking. We examined whether haptoglobin may be effective in preventing AKI requiring renal replacement therapy among patients with severe burns. MethOdSWe performed propensity score-matched analyses of the Japanese nationwide Diagnosis Procedure Combination inpatient database. We identified patients with severe burns (burn index ≥ 10) whose data were recorded from 1 July 2010 to 31 March 2013. We compared patients who were administered haptoglobin within 2 days of admission (haptoglobin group) and those who were not administered haptoglobin (control group). The main outcomes were: requirement for renal replacement therapy during admission, 28-day inhospital mortality, length of hospital stay and ventilator-free days. reSultS Eligible patients (n = 3223) from 618 hospitals were categorized into either the haptoglobin group (n = 263) or the control group (n = 2960). Propensity score matching created a matched cohort of 185 pairs with and without haptoglobin. There were no significant differences between the propensity score-matched groups in terms of the proportion of patients requiring renal replacement therapy (control vs haptoglobin, 25.9% vs 31.9%; p = 0.25), ventilator-free days (13 vs 6 days, p = 0.95), length of hospital stay (38 vs. 27, p = 0.45) and 28-day mortality (42.7% vs 46.5%, p = 0.53). cOncluSiOnS Our results suggest that haptoglobin use is not associated with reduced requirement for renal replacement therapy, increased ventilator-free days, length of hospital stay, or reduced 28-day mortality in patients with severe burns.

show abstract

Haptoglobin Reduces Inflammatory Cytokine INF-γ and Facilitates Clot Formation in Acute Severe Burn Rat Model

Cited by 6 publications

References 39 publications

Experimental models of scald burns. A scope review

Experimental models of scald burns. A scope review

Effect of Tranexamic Acid for Traumatic Brain Injury: A Case Report

Haptoglobin use and acute kidney injury requiring renal replacement therapy among patients with severe burn injury: a nationwide database study

Contact Info

Product

Resources

About