Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats

Agay, Diane; Anderson, Richard A.; Sandre, Caroline; Bryden, Noella A.; Alonso, Antonia; Roussel, Anne‐Marie; Chancerelle, Yves

doi:10.1016/j.burns.2004.11.010

Cited by 74 publications

(48 citation statements)

References 30 publications

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“…Many studies have been conducted to examine the relationship between serum Cu and serum Zn levels and various diseases, especially infectious diseases. 1,2,4,5,7,8,10,11,13,14,18 This is the first study that compares the serum Cu/Zn ratios in patients with brucellosis and individuals in two different control groups. In general, there are two types of abnormalities in the levels of trace elements.…”

Section: Discussionmentioning

confidence: 99%

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Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

Üstün¹,

Teğin²,

Geyik³

2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To determine the alterations of serum copper (Cu) and zinc (Zn) levels and Cu/Zn ratio in patients with brucellosis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 170 individuals were included in the study. Of these, 45 (26.5%) currently had acute or sub-acute brucellosis, 35 (20.6%) were previously diagnosed with acute or sub-acute brucellosis and successfully treated, and 90 (52.9%) were healthy volunteers. After fasting overnight for 10 hours, 5 ml of venous blood was taken.from all subjects. Serum Cu and Zn levels were measured using a Unicam 929 Atomic Absorption Spectrophotometer. SPSS 16.0 was used for data analysis. R Re es su ul lt ts s: : Mean serum Cu levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with acute or sub-acute brucellosis and 90 healthy volunteers were 88.6±26, 58.7±13 and 56.7±16 µg/dL, respectively. Mean serum Zn levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with and treated successfully for acute or sub-acute brucellosis and 90 healthy volunteers were 38.3±12, 58.5±14, and 55.8±13 µg/dL, respectively. Serum Cu levels (p<0.001) and Cu/Zn ratios (p<0.001) were statistically significantly higher while serum Zn levels (p<0.001) were lower in patients with acute or sub-acute brucellosis when compared to the individuals who previously diagnosed with acute or sub-acute brucellosis and the healthy volunteers. C Co on nc cl lu us si io on n: : This study revealed significant alterations of serum Cu and Zn levels, and Cu/Zn ratios in patients with acute or sub-acute brucellosis. Serum Cu, Zn, and Cu/Zn ratios may be available biomarkers in the course of acute or sub-acute brucellosis.K Ke ey y W Wo or rd ds s: : Brucellosis; copper; zinc; trace elements; serum; biological markers Ö ÖZ ZE ET T A Am ma aç ç: : Brusellozlu hastalarda serum bakır (Cu) ve çinko (Zn) düzeylerinde ve bakır/çinko oranlarındaki değişiklikleri saptamaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: Çalışmaya toplam 170 birey alındı. Bunların 45'i (26,5%) akut veya sub-akut bruselloz hastası, 35'i (20,6%) daha önce akut veya subakut bruselloz tanısı aldıktan sonra başarılı bir şekilde tedavi edilmiş hastalar ve 90'ı (52,9%) sağlıklı gönüllüler idi. Tüm deneklerden 10 saatlik gece açlığını takiben 5 ml venöz kan alındı. Serum Cu ve Zn düzeyleri Unicam 929 Atomik Absorbsiyon Spektrofotometresi ile ölçüldü. Verilerin incelenmesinde SPSS 16.0 kullanıldı. B Bu ul lg gu ul la ar r: : Akut veya sub-akut brusellozlu 45 hastanın, daha önce akut veya sub-akut bruselloza yakalanan 35 hastanın ve 90 sağlıklı gönüllünün ortalama serum Cu düzeyleri sırasıyla 88,6±26, 58,7±13 ve 56,7±16 µg/dL idi. Akut veya sub-akut brusellozlu 45 hastanın, daha önce akut veya sub-akut bruselloza yakalanan 35 hastanın ve 90 sağlıklı gönüllünün ortalama serum Zn düzeyleri sırasıyla 38,3±12, 58,5±14, ve 55,8±13 µg/dL idi. Daha önce akut veya sub-akut bruselloza yakalananlarla ve s...

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Section: Discussionmentioning

confidence: 99%

“…4,5,12 Different studies have investigated the diagnostic value or metabolic alterations of Cu and Zn, particularly in infectious diseases. 1,2,4,5,11,13,14 Brucellosis is a zoonotic infectious disease that is endemic in the Southeastern region of Turkey. The morbidity of disease is rather high, while its mortality is very low.…”

mentioning

confidence: 99%

Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

Üstün¹,

Teğin²,

Geyik³

2012

Turkiye Klinikleri J Med Sci

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“…Redistribution of Cu and Zn to the liver and Se to the kidney following burn injury was reported. 19) Related metallo-enzyme (SOD for Cu and Zn, catalase for Fe, and GSH-Px for Se) activities also widely used to investigate redox status and/ or oxidative stress. Catalase and GSH-Px activities in lymphocytes were increased after maximal exercise, but SOD activities reduced.…”

Section: Discussionmentioning

confidence: 99%

Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

Matsumoto

Ariyoshi

Terada

et al. 2006

JOURNAL OF HEALTH SCIENCE

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“…Several studies associated an increased antioxidant activity to counteract the oxidative stress-induced by thermal injury [19]. CuZnSOD expression as front-line antioxidant increases as compensatory reaction early post-burn when oxidative stress increases [20,21]. Ding et al (2002) show an increased glutathioneperroxidase (GSH-Px) activity 24 h after thermal injury that may result from the activation of oxygen responsive element (ORE) in GSH-Px gene by high oxygen level.…”

Section: Oxidative Stress In the Pathogenesis Of Liver Injury And Melmentioning

confidence: 99%

Melatonin protection against burn-induced liver injury. A review

et al. 2014

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AbstractSevere thermal injury may be complicated by dysfunction of organs distant from the original burn wound, including the liver, and represents a serious clinical problem. Although pathophysiology of burn-induced liver injury remains unclear, increasing evidence implicate activation of inflammatory response, oxidative stress, endothelial dysfunction and microcirculatory disorders as the main mechanisms of hepatic injury. Several studies suggest melatonin as a multifunctional indolamine that counteracts some of the pathophysiologic steps and displays significant beneficial effects against burn-induced cellular injury. This review summarizes the role of melatonin in restricting the burn-induced hepatic injury and focuses on its effects on oxidative stress, inflammatory response, endothelial dysfunction and microcirculatory disorders as well as on signaling pathways such as regulation of nuclear erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappaB (NF-kB). Further studies are necessary to elucidate the modulating effect of melatonin on the transcription factor responsible for the regulation of the pro-inflammatory and antioxidant genes involved in burn injuries.

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Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats

Cited by 74 publications

References 30 publications

Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

Melatonin protection against burn-induced liver injury. A review

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