Alterations of Brain Structural Network in Parkinson’s Disease With and Without Rapid Eye Movement Sleep Behavior Disorder

Guo, Tao; Guan, Xiaojun; Zeng, Qiaoling; Xuan, Min; Gu, Quanquan; Huang, Peiyu; Xu, Xiaojun; Zhang, Minming

doi:10.3389/fneur.2018.00334

Cited by 24 publications

(27 citation statements)

References 66 publications

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“…However, this study finds that the PDD with fall group had significantly less GMV in the left calcarine and right inferior frontal gyrus than that of the PDD without fall group. This finding is similar to a study comparing the brain structures of PD patients with and without rapid eye movement sleep behavior disorder [ 40 ]. Furthermore, the association between sleep disorders and falls in PD patients has been reported in a separate case-control study [ 41 ].…”

Section: Discussionsupporting

confidence: 91%

Reduced Gray Matter Volume and Risk of Falls in Parkinson’s Disease with Dementia Patients: A Voxel-Based Morphometry Study

Cheng

Lin

Chen

et al. 2020

IJERPH

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Purpose: Risk of falls is a common sequela affecting patients with Parkinson’s disease (PD). Although motor impairment and dementia are correlated with falls, associations of brain structure and cognition deficits with falls remain unclear. Material and Methods: Thirty-five PD patients with dementia (PDD), and 37 age- and sex-matched healthy subjects were recruited for this study. All participants received structural magnetic resonance imaging (MRI) scans, and disease severity and cognitive evaluations. Additionally, patient fall history was recorded. Regional structural differences between PDD with and without fall groups were performed using voxel-based morphometry processing. Stepwise logistic regression analysis was used to predict the fall risk in PDD patients. Results: The results revealed that 48% of PDD patients experienced falls. Significantly lower gray matter volume (GMV) in the left calcarine and right inferior frontal gyrus in PDD patients with fall compared to PDD patients without fall were noted. The PDD patients with fall exhibited worse UPDRS-II scores compared to PDD patients without fall and were negatively correlated with lower GMV in the left calcarine (p/r = 0.004/−0.492). Furthermore, lower GMV in the left calcarine and right inferior frontal gyrus correlated with poor attention and executive functional test scores. Multiple logistic regression analysis showed that the left calcarine was the only variable (p = 0.004, 95% CI = 0.00–0.00) negatively associated with the fall event. Conclusions: PDD patients exhibiting impaired motor function, lower GMV in the left calcarine and right inferior frontal gyrus, and notable cognitive deficits may have increased risk of falls.

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Section: Discussionsupporting

confidence: 91%

Reduced Gray Matter Volume and Risk of Falls in Parkinson’s Disease with Dementia Patients: A Voxel-Based Morphometry Study

Cheng

Lin

Chen

et al. 2020

IJERPH

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“…This was consistent with previous studies (11,17,25,26). That is to say, the information of brain can be integrated effectively in both PD patients and NC.…”

Section: Small-world Properties and Global Measure Of Pd And Ncsupporting

confidence: 93%

“…It receives information from "homeostatic afferent" sensory pathways through the thalamus and sends output to some other limbic-related structures, such as the amygdala and ventral striatum (39). A study focused on structural correlation network reported that the nodal betweenness and degree of limbic system was increased (11). And a PET study of iRBD reported increased metabolism in hippocampus.…”

Section: Increased Efficiency Of Bilateral Thalamus (Pd-prbd Vs Pd-nmentioning

confidence: 99%

“…Some researchers successively explored structure changes in PD-RBD patients using voxel-based morphometry, diffusion tensor imaging and structural correlation network methods. They found PD-RBD has decreased volume in more or less cortical and subcortical structures such as thalamus, hippocampus, and cingulate cortex (6)(7)(8)(9)(10)(11)(12). In addition to brain structure, a few researchers also used the resting-state functional MRI (rs-fMRI) to search changes of brain function in PD-RBD.…”

Section: Introductionmentioning

confidence: 99%

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Altered Brain Functional Network in Parkinson Disease With Rapid Eye Movement Sleep Behavior Disorder

Zeng

Zhou

et al. 2020

Front. Neurol.

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Background and Objective: Parkinson disease (PD) with rapid eye movement (REM) sleep behavior disorder (PD-RBD) tend to be a distinct phenotype with more severe clinical characteristics and pathological lesion when compared with PD without RBD (PD-nRBD). However, the pathological mechanism underlying PD-RBD remains unclear. We aim to use the resting-state functional magnetic resonance imaging (rs-fMRI) to explore the mechanism of PD-RBD from the perspective of internal connectivity networks. Materials and Methods: A total of 92 PD patients and 20 age and sex matched normal controls (NC) were included. All participants underwent rs-fMRI scan and clinical assessment. According to the RBD screening questionnaire (RBDSQ), PD patients were divided into two groups: PD with probable RBD (PD-pRBD) and PD without probable RBD (PD-npRBD). The whole brain was divided into 90 regions using automated anatomic labeling atlas. Functional network of each subject was constructed according to the correlation of rs-fMRI blood oxygenation level dependent signals in any two brain regions and network metrics were analyzed using graph theory approaches. Network properties among three groups were compared and correlation analysis was made using distinguishing network metrics and RBDSQ scores. Results: We found both PD-pRBD and PD-npRBD patients existed small-world characteristics. PD-pRBD showed a wider range of nodal property changes in neocortex and limbic system than PD-npRBD patients when compared with NC. Besides, PD-pRBD showed significant enhanced nodal efficiency in the bilateral thalamus and betweenness centrality in the left insula, but, reduced betweenness centrality in the right dorsolateral superior frontal gyrus when compared with PD-npRBD. Moreover, nodal efficiency in the bilateral thalamus were positively correlated with RBDSQ scores. Conclusions: Both NC and PD patients displayed small-world properties and indiscriminate global measure but PD-pRBD showed more extensive changes of nodal properties than PD-npRBD. The increased centrality role in the bilateral thalamus and the left insula, and disruption in the right dorsolateral superior frontal gyrus may play as a key role in underlying pathogenesis of PD-RBD.

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“…Resilience indicates the tolerance of the network against random or targeted attack, and is relevant to the stability of the network ( Achard et al, 2006 ; He et al, 2008 ). Various neurological diseases are characterized by the topological properties of the brain structural covariance network ( Yao et al, 2010 ; Shi et al, 2012 ; Tao et al, 2018 ; Zou et al, 2018 ; Liu et al, 2019 ), such as the small-world property, network centrality, and resilience ( He et al, 2008 , 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Topological Properties of Brain Structural Covariance Networks in Patients With Cervical Spondylotic Myelopathy

Kuang

Zha

Liu

et al. 2020

Front. Hum. Neurosci.

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Background: Brain structural alterations play an important role in patients with cervical spondylotic myelopathy (CSM). However, while there have been studies on regional brain structural alterations, only few studies have focused on the topological organization of the brain structural covariance network. This work aimed to describe the structural covariance network architecture alterations that are possibly linked to cortex reorganization in patients with CSM. Methods: High-resolution anatomical images of 31 CSM patients and 31 healthy controls (HCs) were included in the study. The images were acquired using a sagittal three-dimensional T1-weighted BRAVO sequence. Firstly, the gray matter volume of 90 brain regions of automated anatomical labeling atlas were computed using a VBM toolbox based on the DARTEL algorithm. Then, the brain structural covariance network was constructed by thresholding the gray matter volume correlation matrices. Subsequently, the network measures and nodal property were calculated based on graph theory. Finally, the differences in the network metrics and nodal property between groups were compared using a non-parametric test. Results: Patients with CSM showed larger global efficiency and smaller local efficiency, clustering coefficient, characteristic path length, and sigma values than HCs. Patients with CSM had greater betweenness in the left superior parietal gyrus (SPG.L) and the left supplementary motor area (SMA.L) than HCs. Besides, patients with CSM had smaller betweenness in right middle occipital gyrus. The brain structural covariance networks of CSM patients exhibited equal resilience to random failure as those of HCs. However, the maximum relative size of giant connected components was approximately 10% larger in HCs than in CSM patients, upon removal of 44 nodes in targeted attack. Conclusion: These observed alternations in global network measures in CSM patients reflect that the brain structural covariance network in CSM exhibits the less optimal small-world model compared to that in HCs. Increased betweenness in SPG.L and

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Alterations of Brain Structural Network in Parkinson’s Disease With and Without Rapid Eye Movement Sleep Behavior Disorder

Cited by 24 publications

References 66 publications

Reduced Gray Matter Volume and Risk of Falls in Parkinson’s Disease with Dementia Patients: A Voxel-Based Morphometry Study

Reduced Gray Matter Volume and Risk of Falls in Parkinson’s Disease with Dementia Patients: A Voxel-Based Morphometry Study

Altered Brain Functional Network in Parkinson Disease With Rapid Eye Movement Sleep Behavior Disorder

Altered Topological Properties of Brain Structural Covariance Networks in Patients With Cervical Spondylotic Myelopathy

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