Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder

Tomiyama, Hirofumi; Murayama, Keitaro; Nemoto, Kiyotaka; Hasuzawa, Suguru; Mizobe, Taro; Kato, Kenta; Matsuo, Akira; Ohno, Aikana; Kang, Mingi; Togao, Osamu; Hiwatashi, Akio; Ishigami, Kousei; Nakao, Tomohiro

doi:10.1016/j.pnpbp.2022.110516

Cited by 18 publications

(12 citation statements)

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“…In addition, a previous study of static spontaneous brain activity also revealed increased amplitudes of low frequency fluctuation (ALFF) in the insula and precuneus [ 41 ]. Greater intrinsic connectivity between the insula and the precuneus or inferior parietal lobule in OCD patients has been reported in several fMRI studies [ 25 , 42 , 43 ], which was consistent with our results.…”

Section: Discussionsupporting

confidence: 93%

“…Given that our primary aim was to investigate the specific intrinsic functional connectivity patterns of the insula in OCD according to the vital role of the insula in the pathophysiology of this mental disorder, we decided to perform the seed-based resting-state functional connectivity method in the present research, which is a well-targeted method to test the whole-brain intrinsic connectivity of a specific a priori region [20]. In recent years, several studies involving the intrinsic functional connectivity of the insula in OCD patients yielded inconsistent results [21][22][23][24][25]. However, there were some drawbacks in the previous studies, such as relatively small sample sizes and more or less subject to confounding effects of medication or comorbidity.…”

Section: Introductionmentioning

confidence: 99%

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Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder

Zhou

Jiang

et al. 2022

BMC Psychiatry

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Background The function of the insula has been increasingly mentioned in neurocircuitry models of obsessive-compulsive disorder (OCD) for its role in affective processing and regulating anxiety and its wide interactions with the classic cortico-striato-thalamo-cortical circuit. However, the insular resting-state functional connectivity patterns in OCD remain unclear. Therefore, we aimed to investigate characteristic intrinsic connectivity alterations of the insula in OCD and their associations with clinical features. Methods We obtained resting-state functional magnetic resonance imaging data from 85 drug-free OCD patients and 85 age- and sex-matched healthy controls (HCs). We performed a general linear model to compare the whole-brain intrinsic functional connectivity maps of the bilateral insula between the OCD and HC groups. In addition, we further explored the relationship between the intrinsic functional connectivity alterations of the insula and clinical features using Pearson or Spearman correlation analysis. Results Compared with HCs, patients with OCD exhibited increased intrinsic connectivity between the bilateral insula and bilateral precuneus gyrus extending to the inferior parietal lobule and supplementary motor area. Decreased intrinsic connectivity was only found between the right insula and bilateral lingual gyrus in OCD patients relative to HC subjects, which was negatively correlated with the severity of depression symptoms in the OCD group. Conclusion In the current study, we identified impaired insular intrinsic connectivity in OCD patients and the dysconnectivity of the right insula and bilateral lingual gyrus associated with the depressive severity of OCD patients. These findings provide neuroimaging evidence for the involvement of the insula in OCD and suggest its potential role in the depressive symptoms of OCD.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder

Zhou

Jiang

et al. 2022

BMC Psychiatry

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“…When connections between the insula, amygdala, and ACC are disrupted, it can lead to the various visceral, affective, and cognitive features of anxiety (Paulus & Stein, 2006; Williams, 2016, 2017). Our exploratory findings are consistent with prior research showing altered insula-ACC FC in patients with obsessive–compulsive disorder (Fan et al, 2017; Tomiyama et al, 2022), and altered amygdala-ACC FC associated with fear-based anxiety disorders including separation anxiety among youth (Strawn et al, 2014). These exploratory results set the stage for subsequent studies to investigate whether particular anxiety symptoms experienced during stressful events are differentially associated with specific neural circuits.…”

Section: Discussionsupporting

confidence: 91%

Lack of robust associations between prepandemic coping strategies and frontolimbic circuitry with depression and anxiety symptoms during the COVID-19 pandemic: A preregistered longitudinal study.

Cohodes¹,

McCauley²,

Foster³

et al. 2022

Behavioral Neuroscience

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The COVID-19 pandemic is an ongoing stressor that has resulted in the exacerbation of mental health problems worldwide. However, longitudinal studies that identify preexisting behavioral and neurobiological factors associated with mental health outcomes during the pandemic are lacking. Here, we examined associations between prepandemic coping strategy engagement and frontolimbic circuitry with internalizing symptoms during the pandemic. In 85 adults (71.8% female; age 18-30 years), we assessed prototypically adaptive coping strategies (Connor-Davidson Resilience Scale), resting-state functional magnetic resonance imaging functional connectivity (FC) of frontolimbic circuitry, and depression and anxiety symptoms (Beck Depression Inventory, Screen for Child Anxiety-Related Emotional Disorders-Adult, respectively). We conducted general linear models to test preregistered hypotheses that (1) lower coping engagement prepandemic and (2) weaker frontolimbic FC prepandemic would predict elevated symptoms during the pandemic; and (3) coping would interact with FC to predict symptoms during the pandemic. Depression and anxiety symptoms worsened during the pandemic ( ps < .001). Prepandemic adaptive coping engagement and frontolimbic FC were not associated with depression or anxiety symptoms during the pandemic (uncorrected ps > .05). Coping interacted with insula-rostral anterior cingulate cortex (ACC) FC ( p = .003, pFDR = .014) and with insula-ventral ACC FC ( p < .001, pFDR < .001) to predict depression symptoms, but these findings did not survive FDR correction after removal of outliers. Findings from our preregistered study suggest that specific prepandemic factors, particularly adaptive coping and frontolimbic circuitry, are not robustly associated with emotional responses to the pandemic. Additional studies that identify preexisting neurobehavioral factors implicated in mental health outcomes during global health crises are needed.

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“…However, the specific neural substrate of T2DM-related cognitive impairment and emotional disorders remains unclear. The frontostriatal circuits have been shown to play an important role in the pathophysiology of a variety of cognitive and emotional disorders ( Casey et al, 2007 ; Baggio et al, 2015 ; Achterberg et al, 2016 ; Gramespacher et al, 2020 ; Tomiyama et al, 2022 ). Given the impairment of cognitive and emotional functioning in T2DM, the role of frontostriatal connectivity in T2DM is attracting considerable attention ( Looi, 2017 ; Pérez-Taboada et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Functional connectivity (FC) is an effective method to explore impaired frontostriatal circuits ( Di Martino et al, 2008 ; Kelly et al, 2009 ). Previous rs-fMRI studies have indicated that abnormal FC of the frontostriatal circuits impacts cognitive functions and emotional regulation ( Casey et al, 2007 ; Achterberg et al, 2016 ; Lin et al, 2018 ; Gramespacher et al, 2020 ; Tomiyama et al, 2022 ). For example, several studies have revealed that frontostriatal connectivity is reduced in patients with PD and AD ( Middei et al, 2004 ; Anderkova et al, 2017 ; Nieuwhof et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Abnormal functional connectivity of the frontostriatal circuits in type 2 diabetes mellitus

Mei-ling

Wang

et al. 2023

Front. Aging Neurosci.

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BackgroundType 2 diabetes mellitus (T2DM) is a metabolic disorder associated with an increased incidence of cognitive and emotional disorders. Previous studies have indicated that the frontostriatal circuits play a significant role in brain disorders. However, few studies have investigated functional connectivity (FC) abnormalities in the frontostriatal circuits in T2DM.ObjectiveWe aimed to investigate the abnormal functional connectivity (FC) of the frontostriatal circuits in patients with T2DM and to explore the relationship between abnormal FC and diabetes-related variables.MethodsTwenty-seven patients with T2DM were selected as the patient group, and 27 healthy peoples were selected as the healthy controls (HCs). The two groups were matched for age and sex. In addition, all subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological evaluation. Seed-based FC analyses were performed by placing six bilateral pairs of seeds within a priori defined subdivisions of the striatum. The functional connection strength of subdivisions of the striatum was compared between the two groups and correlated with each clinical variable.ResultsPatients with T2DM showed abnormalities in the FC of the frontostriatal circuits. Our findings show significantly reduced FC between the right caudate nucleus and left precentral gyrus (LPCG) in the patients with T2DM compared to the HCs. The FC between the prefrontal cortex (left inferior frontal gyrus, left frontal pole, right frontal pole, and right middle frontal gyrus) and the right caudate nucleus has a significant positive correlation with fasting blood glucose (FBG).ConclusionThe results showed abnormal FC of the frontostriatal circuits in T2DM patients, which might provide a new direction to investigate the neuropathological mechanisms of T2DM.

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Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder

Cited by 18 publications

References 70 publications

Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder

Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder

Lack of robust associations between prepandemic coping strategies and frontolimbic circuitry with depression and anxiety symptoms during the COVID-19 pandemic: A preregistered longitudinal study.

Abnormal functional connectivity of the frontostriatal circuits in type 2 diabetes mellitus

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