Alterations of Gut Microbiota among Children with Autism Spectrum Disorder

Nakazawa-Miklaševiča, Miki; Daneberga, Zanda; Murmane, Daiga; Kroiča, Juta; Cupane, Liene; Isarova, Dana; Berga-Švītiņa, Egija; Masinska, Madara; Miklaševičs, Edvīns

doi:10.3103/s0891416821050104

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Both clinical trials and preclinical studies have shown significant changes in gut microbiota composition in ASD children and animals. In terms of phylum, the amount and ratio of Firmicutes and Bacteroidetes and the amount of Proteobacteria in ASD children were abnormal compared with those in healthy children ( 24 – 27 ). Genus and species levels of gut microbiota in ASD were also abnormal, including Bifidobacterium , Lactobacillus , Bacteroides , Clostridium , Vibrio desulfurization , Akkermansia , Roseburia , Atopobium , Enterobacter , Dorea , Sutterella , Ruminococcus and so on ( 28 , 29 ).…”

Section: Discussionmentioning

confidence: 86%

The role of microbiota in autism spectrum disorder: A bibliometric analysis based on original articles

Lin

Zhou²,

Liang³

et al. 2022

Front. Psychiatry

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BackgroundGastrointestinal (GI) symptoms can be observed in autism spectrum disorder (ASD) children. It is suggested that the gut microbiota and its metabolites are associated, not only with GI symptoms, but also with behaviors of ASD. The aim of this study was to explore the development context, research hotspots and frontiers of gut microbiota and ASD from January 1, 1980 to April 1, 2022 by bibliometric analysis.Materials and methodsPublications of ASD and gut microbiota research from 1 January 1980 to 1 April 2022 were retrieved from the Web of Science Core Collection (WoSCC). Publications and citations trends were analyzed by Excel 2010. CiteSpace was used to analyze countries/regions, authors, institutes, references, and keywords and to visualize the knowledge map.ResultsA total of 1027 studies were retrieved, and 266 original articles were included after screening. The most published countries and institutes were the United States and King Saud University. Afaf El-Aansary published the most articles, while Finegold SM had the highest co-citations. Hotspots and emerging trends in this area may be indicated by co-cited references and keywords and their clusters, including “gut-brain axis,” “behavior,” “chain fatty acid,” “brain,” “feces,” “propionic acid,” “clostridium perfringens,” and “species clostridium innocuum.”ConclusionThe United States dominants the research in this field, which focuses on the alterations of gut microbiota composition and its metabolites, among which the roles of the genus Clostridium and metabolites of short-chain fatty acids, especially propionic acid, are priorities. Fecal microbiota transplantation (FMT) is a promising complementary therapy. In general, research in this area is sparse, but it still has great research prospects.

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Section: Discussionmentioning

confidence: 86%

The role of microbiota in autism spectrum disorder: A bibliometric analysis based on original articles

Lin

Zhou²,

Liang³

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

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Disrupted gut harmony in attention-deficit/hyperactivity disorder: Dysbiosis and decreased short-chain fatty acids

Steckler,

Magzal,

Kokot

et al. 2024

Brain, Behavior, & Immunity - Health

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The Effect of Gut Microbiome, Neurotransmitters, and Digital Insights in Autism

Bamicha,

Pergantis,

Drigas

2024

Applied Microbiology

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Background: Autism spectrum disorder is a multifactorial phenomenon whose genetic, biological, environmental, and nutritional factors outline the heterogeneous phenotype of the disease. A limitation in social connections with others, stereotyped reactions, and specific interests and preferences characterize the behavioral manifestations of a person with autism. Also, weaknesses are found in emotional, cognitive, and metacognitive development, significantly burdening the individual’s quality of life. Lately, it has gained widespread acceptance that the gut microbiome and neurotransmission constitute two decisive etiological factors of autism both in the prenatal period and postnatally. This study aims to investigate data on the interaction between the quantitative and qualitative composition of the gut flora and neurotransmission in humans, as well as their influences on the appearance and progression of the symptoms of autism spectrum disorder. At the same time, it captures the role of digital technology in diagnosing and intervening in autism, which is mainly related to the individual subjects under study. Methods: The current research employs an exploratory review to provide a concise overview of the complex neuronal functions associated with neurotransmitter action and the homeostasis mechanisms that allow the brain and the human body to survive and perform optimally. Results: A review of 111 sources highlighted the connection of dietary habits with synthesizing and releasing neurotransmitters and their influence on the emergence of autism-related behaviors. Conclusions: The literature review’s findings revealed the importance and influence of nutritional factors on neurotransmission performance and behavioral, social, and cognitive development among individuals with autism. Moreover, it is noteworthy that combining a healthy lifestyle and the targeted use of digital tools can improve the intensity of autism symptoms.

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Alterations of Gut Microbiota among Children with Autism Spectrum Disorder

Cited by 3 publications

References 27 publications

The role of microbiota in autism spectrum disorder: A bibliometric analysis based on original articles

The role of microbiota in autism spectrum disorder: A bibliometric analysis based on original articles

Disrupted gut harmony in attention-deficit/hyperactivity disorder: Dysbiosis and decreased short-chain fatty acids

The Effect of Gut Microbiome, Neurotransmitters, and Digital Insights in Autism

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