Alterations of histamine metabolism after injections of sex hormones in mice

Henningsson, Stig; Rosengren, E.

doi:10.1111/j.1476-5381.1972.tb07288.x

Cited by 20 publications

(10 citation statements)

References 16 publications

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“…It is known that oestrogen, originating from the placenta, is present in new-born mammals. The protracted alteration in histidine decarboxylase activity during the first weeks after birth has a related counterpart in the following observation: a high histamine formation by mouse kidney persisted for weeks after discontinuing oestrogen treatment (Henningsson & Rosengren, 1972). The marked decrease in histidine decarboxylase activity of the kidney after ovariectomy strengthens the view that the normally high enzyme level is maintained by gonadal activity.…”

Section: Discussionsupporting

confidence: 51%

“…In female mice it was noted that oestrogen and testosterone administration greatly altered the rate of formation of histamine and putrescine and these changes were reflected in the urinary excretion of the diamines (Henningsson & Rosengren, 1972; Grahn, Henningsson, Kahlson & Rosengren, 1973). In these experiments it was shown that oestrogen injections increased histamine formation in the kidney.…”

Section: Introductionmentioning

confidence: 99%

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Biosynthesis of histamine and putrescine in mice during post‐natal development and its hormone dependence.

Henningsson¹,

Rosengren²

1975

The Journal of Physiology

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1. Histidine decarboxylase and ornithine decarboxylase activities were determined in mouse kidney and liver during post‐natal development. 2. The content of histamine, putrescine, spermidine and spermine was examined in kidney and liver and in the urine of adult male and female mice. 3. Histamine formation by the kidney was high in both sexes when determined a few days after birth but decreased during weaning. Thereafter, a distinct sex difference was established in that in the female kidney the level of histidine decarboxylase rose several‐fold during adolescence while in the male the level was still further reduced. 4. Putrescine formation by mouse kidney was low in both sexes up to three weeks of age whereafter the amine formation in the male increased conspicuously whereas that of the female kidney remained low. 5. The observed sex differences in tissue enzyme activities were reflected in concomitant differences in the amount of the diamines excreted in the urine. 6. No correlation was found between the actual enzyme levels and the assayed tissue content of histamine, putrescine, spermidine and spermine. 7. Following gonadectomy, the activities of both decarboxylases were significantly altered. Ornithine decarboxylase activity of male kidney and histidine decarboxylase activity of female kidney were strikingly reduced. 8. In the mouse liver, the two decarboxylases displayed no changes comparable with that of the kidney during development.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Biosynthesis of histamine and putrescine in mice during post‐natal development and its hormone dependence.

Henningsson¹,

Rosengren²

1975

The Journal of Physiology

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“…The use of an improved method for measuring putrescine in this study confirms this assumption, as is evident from Figure 1. The peak levels excreted in 24 h are roughly ten times higher than those found earlier by Henningsson & Rosengren (1972).…”

Section: Discussionmentioning

confidence: 51%

“…Identification of the yellow DNB (2,4-dinitrobenzene)-product in mouse urine As mentioned above, urine of testosterone-treated mice contained an unidentified compound which gave a yellow product after reaction with DNFB (Henningsson & Rosengren, 1972). As a first step towards identifying the unknown substance, mouse urine was purified by ion-exchange chromatography on a Dowex 50 W-X4 column (Kahlson, Rosengren & Thunberg, 1963).…”

Section: Methodsmentioning

confidence: 99%

“…In a study of various aspects of histamine metabolism in female mice it was noted that testosterone administration greatly reduced urinary histamine excretion, an effect attributable to histidine decarboxylase activity of the kidney being reduced to a small fraction of normal (Henningsson & Rosengren, 1972). In these particular experiments urinary histamine was determined by reaction of the amine with 2,4-dinitrofluorobenzene (DNFB) after purification of the urine on an ion exchange resin.…”

Section: Introductionmentioning

confidence: 99%

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Alterations in the activities of ornithine and histidine decarboxylases provoked by testosterone in mice

Grahn

Henningsson

Kahlson

et al. 1973

British J Pharmacology

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Summary The urinary excretion of putrescine has been determined in female mice before and during repeated injections of testosterone. Testosterone administration effected a striking increase in the excretion of free putrescine. Ornithine decarboxylase (l‐ornithine carboxy‐lyase; E.C. 4.1.1.17) and histidine decarboxylase (l‐histidine carboxy‐lyase; E.C. 4.1.1.22) activities of mouse kidney and liver were examined. In the kidney, following testosterone administration, ornithine decarboxylase activity was found to be substantially elevated, whereas that of histidine decarboxylase was depressed. In the liver, by contrast, the activity levels of these enzymes were not significantly altered by testosterone treatment. The possibility of a functional interrelation between putrescine and histamine, via the two enzyme activities investigated, is discussed.

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Regulation of Tissue Enzymes

Kochakian¹

1976

Anabolic-Androgenic Steroids

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Alterations of histamine metabolism after injections of sex hormones in mice

Cited by 20 publications

References 16 publications

Biosynthesis of histamine and putrescine in mice during post‐natal development and its hormone dependence.

Biosynthesis of histamine and putrescine in mice during post‐natal development and its hormone dependence.

Alterations in the activities of ornithine and histidine decarboxylases provoked by testosterone in mice

Regulation of Tissue Enzymes

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