Alterations of interneurons in the striatum and frontal cortex of mice during postnatal development

Eto, Risa; Abe, Manami; Kimoto, Hiroki; Imaoka, Eri; Kato, Hiroyuki; Kasahara, Jiro; Araki, Tsutomu

doi:10.1016/j.ijdevneu.2010.04.004

Cited by 12 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data also showed a developmental decrease of SOM + and PV + cells in the visual cortex of En2 +/+ mice, though less pronounced than that observed in En2 −/− animals (Figure 3B). Indeed, a decrease of inhibitory interneurons in the mouse frontal cortex has been described to occur during postnatal development (Eto et al, 2010). In addition, a recent study showed that in layers II–III of the mouse primary visual cortex, PV + cell density increases from P28 to P42, and then decreases until P70 (Ye and Miao, 2013), with no change of total cell density.…”

Section: Discussionmentioning

confidence: 99%

Altered GABAergic markers, increased binocularity and reduced plasticity in the visual cortex of Engrailed-2 knockout mice

Allegra

Genovesi

Maggia

et al. 2014

Front. Cell. Neurosci.

View full text Add to dashboard Cite

The maturation of the GABAergic system is a crucial determinant of cortical development during early postnatal life, when sensory circuits undergo a process of activity-dependent refinement. An altered excitatory/inhibitory balance has been proposed as a possible pathogenic mechanism of autism spectrum disorders (ASD). The homeobox-containing transcription factor Engrailed-2 (En2) has been associated to ASD, and En2 knockout (En2−/−) mice show ASD-like features accompanied by a partial loss of cortical GABAergic interneurons. Here we studied GABAergic markers and cortical function in En2−/− mice, by exploiting the well-known anatomical and functional features of the mouse visual system. En2 is expressed in the visual cortex at postnatal day 30 and during adulthood. When compared to age-matched En2+/+ controls, En2−/− mice showed an increased number of parvalbumin (PV+), somatostatin (SOM+), and neuropeptide Y (NPY+) positive interneurons in the visual cortex at P30, and a decreased number of SOM+ and NPY+ interneurons in the adult. At both ages, the differences in distinct interneuron populations observed between En2+/+ and En2−/− mice were layer-specific. Adult En2−/− mice displayed a normal eye-specific segregation in the retino-geniculate pathway, and in vivo electrophysiological recordings showed a normal development of basic functional properties (acuity, response latency, receptive field size) of the En2−/− primary visual cortex. However, a significant increase of binocularity was found in P30 and adult En2−/− mice, as compared to age-matched controls. Differently from what observed in En2+/+ mice, the En2−/− primary visual cortex did not respond to a brief monocular deprivation performed between P26 and P29, during the so-called “critical period.” These data suggest that altered GABAergic circuits impact baseline binocularity and plasticity in En2−/− mice, while leaving other visual functional properties unaffected.

show abstract

Section: Discussionmentioning

confidence: 99%

Altered GABAergic markers, increased binocularity and reduced plasticity in the visual cortex of Engrailed-2 knockout mice

Allegra

Genovesi

Maggia

et al. 2014

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Although maturation of type I nNOS neurons appears to precede sexual maturity in rodents (Chung et al, 2004; Eto et al, 2010), no such data are available for weakly labeled cortical NK1 neurons. Ontogenetic studies will be needed to evaluate if differences in cortical maturation contributed to the differences in distribution of weakly labeled NK1 neurons reported here.…”

Section: Discussionmentioning

confidence: 99%

Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species

Dittrich¹,

Heiss²,

Warrier³

et al. 2012

Front. Neural Circuits

View full text Add to dashboard Cite

We have previously demonstrated that Type I neuronal nitric oxide synthase (nNOS)-expressing neurons are sleep-active in the cortex of mice, rats, and hamsters. These neurons are known to be GABAergic, to express Neuropeptide Y (NPY) and, in rats, to co-express the Substance P (SP) receptor NK1, suggesting a possible role for SP in sleep/wake regulation. To evaluate the degree of co-expression of nNOS and NK1 in the cortex among mammals, we used double immunofluorescence for nNOS and NK1 and determined the anatomical distribution in mouse, rat, and squirrel monkey cortex. Type I nNOS neurons co-expressed NK1 in all three species although the anatomical distribution within the cortex was species-specific. We then performed in vitro patch clamp recordings in cortical neurons in mouse and rat slices using the SP conjugate tetramethylrhodamine-SP (TMR-SP) to identify NK1-expressing cells and evaluated the effects of SP on these neurons. Bath application of SP (0.03–1 μM) resulted in a sustained increase in firing rate of these neurons; depolarization persisted in the presence of tetrodotoxin. These results suggest a conserved role for SP in the regulation of cortical sleep-active neurons in mammals.

show abstract

“…The onset of PV expression in these interneurons is unknown, but as these interneurons are involved in processing of primary sensory information from receptors in the skin, ablation of munc18-1 in these neurons is unlikely to produce the motor coordination defects observed in these experiments. There is also widespread expression of PV in GABAergic interneurons in the cortex and basal ganglia, but in mice relatively few neurons express PV during the first postnatal week compared with adult animals [17, 22, 24]. Generalized loss of GABAergic transmission following ablation of munc18-1 in PV-expressing interneurons may lead to increased potential for seizures in munc18-1 conditional mutants, but spontaneous seizures were not observed in our experiments.…”

Section: Discussionmentioning

confidence: 77%

Quantitative analysis of locomotor defects in neonatal mice lacking proprioceptive feedback

Dallman

Ladle

2013

Physiology & Behavior

View full text Add to dashboard Cite

Proprioceptive feedback derived from specialized receptors in skeletal muscle is critical in forming an accurate map of limb position in space, and is used by the central nervous system to plan future movements and to determine accuracy of executed movements. Knockout mouse strains for genes expressed by proprioceptive sensory neurons have been generated that result in generalized motor deficits, but these deficits have not been quantitatively characterized. Here we characterize a conditional knockout mouse model where proprioceptive sensory neuron synaptic transmission has been blocked by selective ablation of munc18-1, a synaptic vesicle associated protein required for fusion of synaptic vesicles with the plasma membrane. Proprioceptive munc18-1 conditional mutants are impaired in surface righting—a dynamic postural adjustment task—and display several specific deficits in pivoting, an early locomotor behavior. Before the emergence of forward locomotion during postnatal development, animals explore their surroundings through pivoting, or rotating the upper torso around the relatively immobile base of the hind limbs. 3-D kinematic analysis was used to quantitatively describe this pivoting behavior at postnatal days 5 and 8 in control and munc18-1 conditional mutants. Mutant animals also pivot, but demonstrate alterations in movement strategy and in postural placement of the forelimbs during pivoting when compared to controls. In addition, brief forelimb stepping movements associated with pivoting are altered in mutant animals. Step duration and step height is increased in mutant animals. These results underscore the importance of proprioceptive feedback even at early stages in postnatal development.

show abstract

Alterations of interneurons in the striatum and frontal cortex of mice during postnatal development

Cited by 12 publications

References 29 publications

Altered GABAergic markers, increased binocularity and reduced plasticity in the visual cortex of Engrailed-2 knockout mice

Altered GABAergic markers, increased binocularity and reduced plasticity in the visual cortex of Engrailed-2 knockout mice

Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species

Quantitative analysis of locomotor defects in neonatal mice lacking proprioceptive feedback

Contact Info

Product

Resources

About