2012
DOI: 10.3389/fncir.2012.00031
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Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species

Abstract: We have previously demonstrated that Type I neuronal nitric oxide synthase (nNOS)-expressing neurons are sleep-active in the cortex of mice, rats, and hamsters. These neurons are known to be GABAergic, to express Neuropeptide Y (NPY) and, in rats, to co-express the Substance P (SP) receptor NK1, suggesting a possible role for SP in sleep/wake regulation. To evaluate the degree of co-expression of nNOS and NK1 in the cortex among mammals, we used double immunofluorescence for nNOS and NK1 and determined the ana… Show more

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Cited by 32 publications
(34 citation statements)
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References 77 publications
(120 reference statements)
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“…S6). Although only ∼70% of cortical NK1 neurons in rats coexpress nNOS (14,15), overlap of these two markers in the mouse cortex is virtually complete (14). Because nNOS KO mice are deficient in the as the proportion of the entire NREM spectra during RS in WT and KO.…”
Section: Cortical Nnos/nk1 Cells Are Activated By Sleep Deprivation Imentioning
confidence: 99%
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“…S6). Although only ∼70% of cortical NK1 neurons in rats coexpress nNOS (14,15), overlap of these two markers in the mouse cortex is virtually complete (14). Because nNOS KO mice are deficient in the as the proportion of the entire NREM spectra during RS in WT and KO.…”
Section: Cortical Nnos/nk1 Cells Are Activated By Sleep Deprivation Imentioning
confidence: 99%
“…Sleep-active nNOS cells correspond to type I nNOS neurons, which are larger and less numerous than type II cells, express the neurokinin-1 receptor (NK1; 14,15), and are likely projection neurons (16,17). On the basis of these observations, we have proposed that cortical nNOS/ NK1 neurons are fundamentally related to the homeostatic regulation of sleep and play a critical role in coordinating slow waves within the cortex, possibly through release of NO (18).…”
mentioning
confidence: 99%
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“…mRNA levels of the gene coding for SP are increased in the cortex by SD (Martinowich et al, 2011). Cortical nNOS neurons co-express the SP receptor NK1 and are strongly and directly activated in vitro by SP (Dittrich et al, 2012).…”
Section: Regulation Of Nnos/nk1 Neuronsmentioning
confidence: 99%
“…We have recently described a population of cortical GABAergic interneurons that is specifically activated during sleep (Gerashchenko et al, 2008;Pasumarthi et al, 2010). These neurons are identified by colocalized immunoreactivity for neuronal nitric oxide synthase (nNOS) and the substance P (SP) receptor NK1 (Dittrich et al, 2012). Activation of these neurons, assessed by immunoreactivity for the functional activity marker Fos, correlates with time spent in NREM sleep as well as with NREM delta power (Gerashchenko et al, 2008;Morairty et al, 2013).…”
Section: Introductionmentioning
confidence: 99%