Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Taşdemir, Ufuk; Taşdemir, Nicel; Kılıç, Sevtap; Abalı, Remzi; Çelik, Cem; Gülerman, Hacer Cavidan

doi:10.1159/000365813

Cited by 23 publications

(11 citation statements)

References 21 publications

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“…GDM insulin resistance and hyperinsulinemia may cause microvascular disease, resulting in the thickening of the basement membrane in capillary walls. This also contributes to the occurrence of maternal hypertensive disorders in pregnancy (26). In the present study, patients in the groups receiving high and medium doses of vitamin D supplementation were observed to display reduced insulin, HOMA-IR and total cholesterol levels.…”

Section: Discussionsupporting

confidence: 49%

Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial

Zhang

Chen

et al. 2016

Experimental and Therapeutic Medicine

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It has previously been reported that the influence of vitamin D on the metabolism of calcium and phosphorus is associated with diabetes, cardiovascular disease, Alzheimer's disease, cancer and other systemic diseases, and is considered an important indicator of general health. The present study was conducted to determine the effect of various doses of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation and the levels of oxidative stress of pregnant women with gestational diabetes mellitus (GDM). The present randomized, double-blind placebo-controlled clinical trial was conducted on 133 pregnant women with GDM during weeks 24-28 of pregnancy. The patients were randomly divided into four groups. The control group (n=20) received a placebo (sucrose; one granule/day), the low dosage group (n=38) received the daily recommended intake of 200 IU vitamin D (calciferol) daily, the medium dosage group (n=38) received 50,000 IU monthly (2,000 IU daily for 25 days) and the high dosage group (n=37) received 50,000 IU every 2 weeks (4,000 IU daily for 12.5 days). The general characteristics and dietary intakes of the patients with GDM were similar between each group. Using ELISA kits, it was determined that insulin, homeostatic model assessment-insulin resistance and total cholesterol were significantly reduced by high dosage vitamin D supplementation (P<0.05). Total antioxidant capacity and total glutathione levels were significantly elevated as a result of high dosage vitamin D supplementation (P<0.01). In conclusion, high-dose vitamin D supplementation (50,000 IU every 2 weeks) significantly improved insulin resistance in pregnant women with GDM.

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Section: Discussionsupporting

confidence: 49%

Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial

Zhang

Chen

et al. 2016

Experimental and Therapeutic Medicine

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“…Changes in magnesium status in pregnant women may translate into effects on glucose metabolism, blood pressure, and the contractile response of uterine muscle. Thus, earlier reductions in maternal magnesium have been associated with an increased incidence of gestational diabetes [ 65 , 66 , 67 ] and may contribute to both preterm delivery and preeclampsia [ 36 , 68 , 69 ]. Few well-designed trials have examined the impact of dietary magnesium supplementation in pregnant women; thus, the benefits and risks of such remain controversial [ 70 ].…”

Section: Resultsmentioning

confidence: 99%

Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis

et al. 2017

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Magnesium (Mg) is an essential mineral in the body, impacting the synthesis of biomacromolecules, bone matrix development, energy production, as well as heart, nerve, and muscle function. Although the importance of Mg is evident, reference values for serum Mg (sMg) in pediatric patients (more specifically, in neonates) are not well established. This systematic literature review and meta-analysis (using 47 eligible studies) aims to quantify normal and tolerable ranges of sMg concentrations during the neonatal period and to highlight the factors influencing Mg levels and the importance of regulating sMg levels during pregnancy and birth. In newborns without Mg supplementation during pregnancy, magnesium levels at birth (0.76 (95% CI: 0.52, 0.99) mmol/L) were similar to that of mothers during pregnancy (0.74 (95% CI: 0.43, 1.04) mmol/L), but increased during the first week of life (0.91 (95% CI: 0.55, 1.26) mmol/L) before returning to adult levels. This pattern was also seen in newborns with Mg supplementation during pregnancy, where the average was 1.29 (95% CI: 0.50, 2.08) mmol/L at birth and 1.44 (95% CI: 0.61, 2.27) mmol/L during the first week of life. Factors influencing these levels include prenatal Mg supplementation, gestational age, birth weight, renal maturity/function, and postnatal Mg intake. Elevated Mg levels (>2.5 mmol/L) have been associated with an increased risk of mortality, admission into intensive care, hypotonia, hypotension, and respiratory depression but sMg concentrations up to 2.0 mmol/L appear to be well tolerated in neonates, requiring adequate survey and minimal intervention.

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“…The low serum magnesium levels seen in the diabetic population may be a consequence of insulin resistance and dietary magnesium intake and intestinal hypo absorption may also be a factor in the low serum magnesium levels. Goker Tasdemir et al (2015) 16 found that there is no statistically significant difference in serum magnesium concentrations between healthy pregnant women and women with GDM.…”

Section: Discussionmentioning

confidence: 99%

Estimation of Serum Magnesium in Bangladeshi Gestational Diabetic Mother

Mishu¹,

Haque²

2018

Anwer Khan Mod Med Coll J

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Background: Gestational diabetes mellitus (GDM) is characterized by glucose intolerance during pregnancy.GDM is associated with an increased incidence of congenital abnormalities usually aggravated by maternal magnesium deficiency. Magnesium is one of the essential trace elements for normal embryogenesis and foetal growth and its deficiency increase mortality and morbidity rate of mothers, embryos and neonates.Objective: To evaluate the association of serum magnesium with GDM in second and third trimester. Materials & Methods: This case control study was conducted in Mymensingh Medical College Hospital during the period from July 2013 to June 2014 to evaluate the association of magnesium with GDM in Bangladeshi women. A total number of 172 subjects were participated in this study; among them eighty six women diagnosed with GDM were selected as case (Group-I) and eighty six healthy pregnant women were control (Group-II). The case group again subdivided as Group Ia and Ib second and third trimester respectively. Control group also subdivided as Group IIa and IIb second and third trimester respectively. Student's unpaired t test was used to analyse the data between groups. For analytical purpose 95% confidence limit (p<0.05) was taken as level of significance.Results: Serum Magnesium levels were significantly decreased in cases compared to control group. Highly significant difference (p<0.001) was found between Gr-Ia and Gr-IIa. The result was also highly significant (p<0.001) when compared between Gr-Ib and Gr-IIb .Conclusion: Estimation of serum magnesium level should be incorporated in every GDM cases for prevention of complications.Anwer Khan Modern Medical College Journal Vol. 9, No. 2: Jul 2018, P 110-113

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Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Cited by 23 publications

References 21 publications

Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial

Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial

Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis

Estimation of Serum Magnesium in Bangladeshi Gestational Diabetic Mother

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