Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45min of a Turkish bath or running

Aydın, Süleyman; Kuloğlu, Tuncay; Yılmaz, Musa; Kalaycı, Mehmet; Şahin, İ̇brahim; Çiçek, Demet

doi:10.1016/j.peptides.2013.09.011

Cited by 109 publications

(94 citation statements)

References 34 publications

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“…These results contribute new evidence to regulation of irisin levels during steady-state acute physical activity, suggesting that irisin signaling occurs during the first hour of exercise (9). To date, the majority of studies have measured irisin levels in plasma or serum; however, Aydin et al (12) provide the first demonstration of irisin in the saliva, supported by their results showing strong irisin immunoreactivity in human submandibular glands. Interestingly, they observed a significant increase in irisin levels in the saliva after moderate outdoor exercise (5.5 km/45 min) in a middle-aged normal weight population (nZ14) (12).…”

Section: Clinical Study S S Daskalopoulou a B Cooke And Othersmentioning

confidence: 62%

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Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

Daskalopoulou¹,

Cooke²,

Gomez³

et al. 2014

European Journal of Endocrinology

179

119

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Background: Irisin, a recently discovered myokine, has been shown to induce browning of white adipose tissue, enhancing energy expenditure and mediating some of the beneficial effects of exercise. We aimed to estimate the time frame of changes in irisin levels after acute exercise and the effect of different exercise workloads and intensities on circulating irisin levels immediately post-exercise. Methods: In a pilot study, four healthy subjects (22.5G1.7 years) underwent maximal workload exercise (maximal oxygen consumption, VO 2 max ) and blood was drawn at prespecified intervals to define the time frame of pre-and post-exercise irisin changes over a 24-h period. In the main study, 35 healthy, non-smoking (23.0G3.3 years) men and women (nZ20/15) underwent three exercise protocols R48-h apart, in random order: i) maximal workload (VO 2 max ); ii) relative workload (70% of VO 2 max /10 min); and iii) absolute workload (75 W/10 min). Blood was drawn immediately pre-exercise and 3 min post-exercise. Results: In the pilot study, irisin levels increased by 35% 3 min post-exercise, then dropped and remained relatively constant. In the main study, irisin levels post-exercise were significantly higher than those of pre-exercise after all workloads (all, P!0.001). Post-to-pre-exercise differences in irisin levels were significantly different between workloads (PZ0.001), with the greatest increase by 34% following maximal workload (PZ0.004 vs relative and absolute). Conclusions: Circulating irisin levels were acutely elevated in response to exercise, with a greater increase after maximal workload. These findings suggest that irisin release could be a function of muscle energy demand. Future studies need to determine the underlying mechanisms of irisin release and explore irisin's therapeutic potential.

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Section: Clinical Study S S Daskalopoulou a B Cooke And Othersmentioning

confidence: 62%

“…To date, few human studies have directly looked at the effect of acute exercise on circulating irisin levels (8,9,10,11,12). We previously examined the effects of an acute bout of exercise (short sprints) in young healthy men (nZ15) and demonstrated that circulating irisin levels were increased 30 min after completion of acute exercise (8).…”

mentioning

confidence: 99%

Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

Daskalopoulou¹,

Cooke²,

Gomez³

et al. 2014

European Journal of Endocrinology

179

119

View full text Add to dashboard Cite

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“…But there were significant higher differences between obese and non-obese groups both control and PCOS this explained the correlation with BMI. To date, there have been reports of the positive [21,[45][46][47][48], negative [24,[49][50][51] and no correlations [44,45,52,53] between serum irisin and body mass index (BMI). Decreased levels of circulating irisin have been found in T2DM patients compared with non-diabetic controls [46].…”

Section: Discussionmentioning

confidence: 99%

Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

Ali

Al-nuaimi

Al-Musawi³

2016

Int J Pharm Pharm Sci

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Objective: This study was aimed to evaluate the effect of serum leptin level on irisin level in relation to glucose homeostasis that to be associated with hormonal changes (Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Prolactin (PRL), Testosterone (TES)) in obese and nonobese women with polycystic ovary syndrome (PCOS). Methods:Fifty women with polycystic ovaries syndrome (PCOS) and thirty-four apparently healthy control women with regular menstruation (28±2days) were included in this study both of PCOS patients and controls were divided into sub-groups according to their body mass index (BMI) into: twenty-five obese (BMI ≥30) with (BMI= 35.934±0.746) and another twenty-five non-obese polycystic ovaries syndrome women (BMI=25.074±0.456). Whereas, controls were divided as seventeen obese (BMI= 37.140±1.470) and seventeen non-obese (BMI= 25.022±0.683) healthy control women with regular menstruation with an age range (20-40 y) and BMI matching that of the patient groups. Venous blood samples were collected to measure serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH, prolactin (PRL), total testosterone (TES), thyroid stimulating hormone (TSH). As well as, fasting glucose, irisin, leptin, and insulin. Besides, estimating Insulin Resistance (HOMA-IR) index, β-cell function was determined using the Homeostasis Model Assessment of β-cell function (HOMA-β).Results: Serum irisin levels were not significantly different from their corresponding controls, in both obese and non-obese PCOS patients. Whereas, serum irisin levels were elevated significantly in both obese (patients and control) as compared to non-obese (patients and controls), respectively. But, serum leptin levels were significantly elevated in obese PCOS patients as compared to their corresponding control group, nonobese control, and non-obese PCOS patients. However, serum leptin levels were not significantly different in non-obese women groups, both the PCOS and controls. The irisin/insulin ratio expressed no significant variations from its corresponding control in non-obese groups. But the obese PCOS patient's values were highly significantly different as compared to their control (p<0.01). Furthermore, irisin/insulin ratio was elevated significantly in obese control as compared to non-obese patients (p = 0.001), but not with non-obese controls (p=0.114). The leptin/insulin ratio was not significantly varied in PCOS groups from their corresponding control in non-obese (p = 0.094) but in obese PCOS patients, there was significantly different as compared to its control (p = 0.01). Furthermore, leptin to insulin ratio was not significantly different between patients groups (non-obese and obese, p=0.133), nor between the studied controls (p=0.705). Conclusion:Although serum irisin levels show no significant variation in subjects in relation to PCOS condition, it seems more to be related to BMI, since it's secreted by adipocytes. And because leptin and irisin levels would be elevated in obese subjects th...

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“…Ayrıca bu çalış-mayla insanlarda submandibuler bez, ekrin bez ve deri altı yağ bezlerinde irisin hormonunun sentezlendiği rapor edilmiştir. 33 Ateş ve ark., obez ve aynı zamanda tiroid hastalığı olan bireylerin, irisin hormonunun tiroid dokusuna, yağ dokusuna ve metabolizmaya etkisini araştırmışlardır. Bu çalışma, 37 sağlıklı ve 37 Hashimato hastalığı tanısı konan, ancak hiç tedavi gör-memiş erişkinlerle yapılmıştır.…”

Section: Di̇ğer İri̇si̇n çAlişmalariunclassified

Irisin and Its Metabolic Effects: Review

Inci¹,

Aypak²

2016

Turkiye Klinikleri J Endocrin

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Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45min of a Turkish bath or running

Cited by 109 publications

References 34 publications

Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

Irisin and Its Metabolic Effects: Review

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